Ca<sup>2+</sup> signaling and lipid transfer ‘pas a deux’ at ER-PM contact sites orchestrate cell migration
<p dir="ltr">Contact sites between the endoplasmic reticulum (ER) and plasma membrane (PM) regulate both non-vesicular lipid transfer as well as Ca<sup>2+</sup> signaling with multiple interactions between the two pathways. Here I discuss recent findings that offer exciti...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| منشور في: |
2020
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513559088594944 |
|---|---|
| author | Khaled Machaca (194372) |
| author_facet | Khaled Machaca (194372) |
| author_role | author |
| dc.creator.none.fl_str_mv | Khaled Machaca (194372) |
| dc.date.none.fl_str_mv | 2020-07-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.ceca.2020.102226 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Ca_sup_2_sup_signaling_and_lipid_transfer_pas_a_deux_at_ER-PM_contact_sites_orchestrate_cell_migration/24225619 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Membrane contact sites STIM1 Orai1 ORP3 IQSec1 Arf5 Non-vesicular lipid transport Calcium signaling Cell migration Focal adhesion |
| dc.title.none.fl_str_mv | Ca<sup>2+</sup> signaling and lipid transfer ‘pas a deux’ at ER-PM contact sites orchestrate cell migration |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Contact sites between the endoplasmic reticulum (ER) and plasma membrane (PM) regulate both non-vesicular lipid transfer as well as Ca<sup>2+</sup> signaling with multiple interactions between the two pathways. Here I discuss recent findings that offer exciting insights into the role of store-operated Ca<sup>2+</sup> entry (SOCE), Oxysterol-binding protein (OSBP)-related proteins ORP3, Arf5 and the Arf GEF IQSec1 in this crosstalk and how they regulate cell migration and focal adhesion disassembly.</p><h2>Other Information</h2><p dir="ltr">Published in: Cell Calcium<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ceca.2020.102226" target="_blank">https://dx.doi.org/10.1016/j.ceca.2020.102226</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_a6668f1b4a33c50ceac7da52a26ee184 |
| identifier_str_mv | 10.1016/j.ceca.2020.102226 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24225619 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Ca<sup>2+</sup> signaling and lipid transfer ‘pas a deux’ at ER-PM contact sites orchestrate cell migrationKhaled Machaca (194372)Biological sciencesBiochemistry and cell biologyMembrane contact sitesSTIM1Orai1ORP3IQSec1Arf5Non-vesicular lipid transportCalcium signalingCell migrationFocal adhesion<p dir="ltr">Contact sites between the endoplasmic reticulum (ER) and plasma membrane (PM) regulate both non-vesicular lipid transfer as well as Ca<sup>2+</sup> signaling with multiple interactions between the two pathways. Here I discuss recent findings that offer exciting insights into the role of store-operated Ca<sup>2+</sup> entry (SOCE), Oxysterol-binding protein (OSBP)-related proteins ORP3, Arf5 and the Arf GEF IQSec1 in this crosstalk and how they regulate cell migration and focal adhesion disassembly.</p><h2>Other Information</h2><p dir="ltr">Published in: Cell Calcium<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ceca.2020.102226" target="_blank">https://dx.doi.org/10.1016/j.ceca.2020.102226</a></p>2020-07-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.ceca.2020.102226https://figshare.com/articles/journal_contribution/Ca_sup_2_sup_signaling_and_lipid_transfer_pas_a_deux_at_ER-PM_contact_sites_orchestrate_cell_migration/24225619CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/242256192020-07-01T00:00:00Z |
| spellingShingle | Ca<sup>2+</sup> signaling and lipid transfer ‘pas a deux’ at ER-PM contact sites orchestrate cell migration Khaled Machaca (194372) Biological sciences Biochemistry and cell biology Membrane contact sites STIM1 Orai1 ORP3 IQSec1 Arf5 Non-vesicular lipid transport Calcium signaling Cell migration Focal adhesion |
| status_str | publishedVersion |
| title | Ca<sup>2+</sup> signaling and lipid transfer ‘pas a deux’ at ER-PM contact sites orchestrate cell migration |
| title_full | Ca<sup>2+</sup> signaling and lipid transfer ‘pas a deux’ at ER-PM contact sites orchestrate cell migration |
| title_fullStr | Ca<sup>2+</sup> signaling and lipid transfer ‘pas a deux’ at ER-PM contact sites orchestrate cell migration |
| title_full_unstemmed | Ca<sup>2+</sup> signaling and lipid transfer ‘pas a deux’ at ER-PM contact sites orchestrate cell migration |
| title_short | Ca<sup>2+</sup> signaling and lipid transfer ‘pas a deux’ at ER-PM contact sites orchestrate cell migration |
| title_sort | Ca<sup>2+</sup> signaling and lipid transfer ‘pas a deux’ at ER-PM contact sites orchestrate cell migration |
| topic | Biological sciences Biochemistry and cell biology Membrane contact sites STIM1 Orai1 ORP3 IQSec1 Arf5 Non-vesicular lipid transport Calcium signaling Cell migration Focal adhesion |