Prevalence of BRCA mutations among hereditary breast and/or ovarian cancer patients in Arab countries: systematic review and meta-analysis
<p>To systematically assess the prevalence of BRCA1 and BRCA2 gene mutations in women with Hereditary Breast and/or Ovarian Cancer (HBOC) in Arab countries and to describe the variability in the BRCA gene mutations in different regions of the Arab world. Observational studies reporting prevale...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , |
| Published: |
2019
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513566645682176 |
|---|---|
| author | Khadiga Abdulrashid (14153097) |
| author2 | Nour AlHussaini (14153100) Wifag Ahmed (14153103) Lukman Thalib (5712299) |
| author2_role | author author author |
| author_facet | Khadiga Abdulrashid (14153097) Nour AlHussaini (14153100) Wifag Ahmed (14153103) Lukman Thalib (5712299) |
| author_role | author |
| dc.creator.none.fl_str_mv | Khadiga Abdulrashid (14153097) Nour AlHussaini (14153100) Wifag Ahmed (14153103) Lukman Thalib (5712299) |
| dc.date.none.fl_str_mv | 2019-03-21T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12885-019-5463-1 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Prevalence_of_BRCA_mutations_among_hereditary_breast_and_or_ovarian_cancer_patients_in_Arab_countries_systematic_review_and_meta-analysis/21598320 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis BRCA mutations Familial breast cancer Familial ovarian cancer Arab countries Systematic review meta-analysis |
| dc.title.none.fl_str_mv | Prevalence of BRCA mutations among hereditary breast and/or ovarian cancer patients in Arab countries: systematic review and meta-analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>To systematically assess the prevalence of BRCA1 and BRCA2 gene mutations in women with Hereditary Breast and/or Ovarian Cancer (HBOC) in Arab countries and to describe the variability in the BRCA gene mutations in different regions of the Arab world. Observational studies reporting prevalence of BRCA mutations from 22 Arab countries were systematically searched in databases including PUBMED, EMBASE, Web of Science, and Google Scholar. Two reviewers independently screened the studies and extracted data and assessed the risk of bias. Hoy’s risk of Bias tool was used to assess the biases in individual studies. Due to substantial heterogeneity, pooled weighted estimates were calculated using Quality Effect Models (QEM) that adjust for bias, while the Random Effect Models (REM) estimates served as the sensitivity estimates. Fourteen studies reporting prevalence of BRCA were included. The pooled estimate of BRCA among HBOC was 20% (95% CI: 7–36%). Subgroup analysis including only those with low risk of bias provided an estimate of 11% (95% CI: 1–27%). Levant region had higher prevalence 28% (95% CI: 11–49%) compared to Arabian Gulf region and North Africa but differences are not statistically significant, when tested using Z-test for proportions. Given the pooled estimates vary widely with substantial heterogeneity, larger, well-designed studies are warranted to better understand the frequency and the impact of BRCA gene mutations among Arab women. International Prospective Register of Systematic Reviews (PROSPERO) registration number: CRD42018095905 .</p><h2>Other Information</h2> <p> Published in: BMC Cancer<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12885-019-5463-1" target="_blank">http://dx.doi.org/10.1186/s12885-019-5463-1</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_a73d2656acdbfb406f0434703a4698d8 |
| identifier_str_mv | 10.1186/s12885-019-5463-1 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21598320 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Prevalence of BRCA mutations among hereditary breast and/or ovarian cancer patients in Arab countries: systematic review and meta-analysisKhadiga Abdulrashid (14153097)Nour AlHussaini (14153100)Wifag Ahmed (14153103)Lukman Thalib (5712299)Biological sciencesGeneticsBiomedical and clinical sciencesOncology and carcinogenesisBRCA mutationsFamilial breast cancerFamilial ovarian cancerArab countries Systematic reviewmeta-analysis<p>To systematically assess the prevalence of BRCA1 and BRCA2 gene mutations in women with Hereditary Breast and/or Ovarian Cancer (HBOC) in Arab countries and to describe the variability in the BRCA gene mutations in different regions of the Arab world. Observational studies reporting prevalence of BRCA mutations from 22 Arab countries were systematically searched in databases including PUBMED, EMBASE, Web of Science, and Google Scholar. Two reviewers independently screened the studies and extracted data and assessed the risk of bias. Hoy’s risk of Bias tool was used to assess the biases in individual studies. Due to substantial heterogeneity, pooled weighted estimates were calculated using Quality Effect Models (QEM) that adjust for bias, while the Random Effect Models (REM) estimates served as the sensitivity estimates. Fourteen studies reporting prevalence of BRCA were included. The pooled estimate of BRCA among HBOC was 20% (95% CI: 7–36%). Subgroup analysis including only those with low risk of bias provided an estimate of 11% (95% CI: 1–27%). Levant region had higher prevalence 28% (95% CI: 11–49%) compared to Arabian Gulf region and North Africa but differences are not statistically significant, when tested using Z-test for proportions. Given the pooled estimates vary widely with substantial heterogeneity, larger, well-designed studies are warranted to better understand the frequency and the impact of BRCA gene mutations among Arab women. International Prospective Register of Systematic Reviews (PROSPERO) registration number: CRD42018095905 .</p><h2>Other Information</h2> <p> Published in: BMC Cancer<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12885-019-5463-1" target="_blank">http://dx.doi.org/10.1186/s12885-019-5463-1</a></p>2019-03-21T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12885-019-5463-1https://figshare.com/articles/journal_contribution/Prevalence_of_BRCA_mutations_among_hereditary_breast_and_or_ovarian_cancer_patients_in_Arab_countries_systematic_review_and_meta-analysis/21598320CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215983202019-03-21T00:00:00Z |
| spellingShingle | Prevalence of BRCA mutations among hereditary breast and/or ovarian cancer patients in Arab countries: systematic review and meta-analysis Khadiga Abdulrashid (14153097) Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis BRCA mutations Familial breast cancer Familial ovarian cancer Arab countries Systematic review meta-analysis |
| status_str | publishedVersion |
| title | Prevalence of BRCA mutations among hereditary breast and/or ovarian cancer patients in Arab countries: systematic review and meta-analysis |
| title_full | Prevalence of BRCA mutations among hereditary breast and/or ovarian cancer patients in Arab countries: systematic review and meta-analysis |
| title_fullStr | Prevalence of BRCA mutations among hereditary breast and/or ovarian cancer patients in Arab countries: systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of BRCA mutations among hereditary breast and/or ovarian cancer patients in Arab countries: systematic review and meta-analysis |
| title_short | Prevalence of BRCA mutations among hereditary breast and/or ovarian cancer patients in Arab countries: systematic review and meta-analysis |
| title_sort | Prevalence of BRCA mutations among hereditary breast and/or ovarian cancer patients in Arab countries: systematic review and meta-analysis |
| topic | Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis BRCA mutations Familial breast cancer Familial ovarian cancer Arab countries Systematic review meta-analysis |