Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways
<p dir="ltr">Gynecological malignancies are a female type of cancers that affects the reproductive system. Cancer metastasis or recurrence mediated by cellular invasiveness occurs at advanced stages of cancer progression. Cancer Stem Cells (CSCs) enrichment in tumors leads to chemore...
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2022
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| _version_ | 1864513540486856704 |
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| author | Lubna Therachiyil (4246156) |
| author2 | Ola J. Hussein (17346952) Shahab Uddin (154400) Hesham M. Korashy (1474849) |
| author2_role | author author author |
| author_facet | Lubna Therachiyil (4246156) Ola J. Hussein (17346952) Shahab Uddin (154400) Hesham M. Korashy (1474849) |
| author_role | author |
| dc.creator.none.fl_str_mv | Lubna Therachiyil (4246156) Ola J. Hussein (17346952) Shahab Uddin (154400) Hesham M. Korashy (1474849) |
| dc.date.none.fl_str_mv | 2022-11-01T21:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.semcancer.2022.10.003 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Regulation_of_the_aryl_hydrocarbon_receptor_in_cancer_and_cancer_stem_cells_of_gynecological_malignancies_An_update_on_signaling_pathways/24516508 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biotechnology Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Reproductive medicine Aryl hydrocarbon receptor CYP1A1/ CYP1B1 Chemoresistance Gynecological cancers Stemness markers Cancer stem cells |
| dc.title.none.fl_str_mv | Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Gynecological malignancies are a female type of cancers that affects the reproductive system. Cancer metastasis or recurrence mediated by cellular invasiveness occurs at advanced stages of cancer progression. Cancer Stem Cells (CSCs) enrichment in tumors leads to chemoresistance, which results in cancer mortality. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons is associated with an increased the risk of CSC enrichment in gynecological cancers. One of the important pathways that mediates the metabolism and bioactivation of these environmental chemicals is the transcription factor, aryl hydrocarbon receptor (AhR). The present review explores the molecular mechanisms regulating the crosstalk and interaction of the AhR with cancer-related signaling pathways, such as apoptosis, epithelial-mesenchymal transition, immune checkpoints, and G-protein-coupled receptors in several gynecological malignancies such as ovarian, uterine, endometrial, and cervical cancers. The review also discusses the potential of targeting the AhR pathway as a novel chemo-therapy for gynecological cancers.</p><h2>Other Information</h2><p dir="ltr">Published in: Seminars in Cancer Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.semcancer.2022.10.003" target="_blank">https://dx.doi.org/10.1016/j.semcancer.2022.10.003</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_a81de5b0082a40100c355d04807ebed9 |
| identifier_str_mv | 10.1016/j.semcancer.2022.10.003 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24516508 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathwaysLubna Therachiyil (4246156)Ola J. Hussein (17346952)Shahab Uddin (154400)Hesham M. Korashy (1474849)Biomedical and clinical sciencesMedical biotechnologyOncology and carcinogenesisPharmacology and pharmaceutical sciencesReproductive medicineAryl hydrocarbon receptorCYP1A1/ CYP1B1ChemoresistanceGynecological cancersStemness markersCancer stem cells<p dir="ltr">Gynecological malignancies are a female type of cancers that affects the reproductive system. Cancer metastasis or recurrence mediated by cellular invasiveness occurs at advanced stages of cancer progression. Cancer Stem Cells (CSCs) enrichment in tumors leads to chemoresistance, which results in cancer mortality. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons is associated with an increased the risk of CSC enrichment in gynecological cancers. One of the important pathways that mediates the metabolism and bioactivation of these environmental chemicals is the transcription factor, aryl hydrocarbon receptor (AhR). The present review explores the molecular mechanisms regulating the crosstalk and interaction of the AhR with cancer-related signaling pathways, such as apoptosis, epithelial-mesenchymal transition, immune checkpoints, and G-protein-coupled receptors in several gynecological malignancies such as ovarian, uterine, endometrial, and cervical cancers. The review also discusses the potential of targeting the AhR pathway as a novel chemo-therapy for gynecological cancers.</p><h2>Other Information</h2><p dir="ltr">Published in: Seminars in Cancer Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.semcancer.2022.10.003" target="_blank">https://dx.doi.org/10.1016/j.semcancer.2022.10.003</a></p>2022-11-01T21:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.semcancer.2022.10.003https://figshare.com/articles/journal_contribution/Regulation_of_the_aryl_hydrocarbon_receptor_in_cancer_and_cancer_stem_cells_of_gynecological_malignancies_An_update_on_signaling_pathways/24516508CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/245165082022-11-01T21:00:00Z |
| spellingShingle | Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways Lubna Therachiyil (4246156) Biomedical and clinical sciences Medical biotechnology Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Reproductive medicine Aryl hydrocarbon receptor CYP1A1/ CYP1B1 Chemoresistance Gynecological cancers Stemness markers Cancer stem cells |
| status_str | publishedVersion |
| title | Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways |
| title_full | Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways |
| title_fullStr | Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways |
| title_full_unstemmed | Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways |
| title_short | Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways |
| title_sort | Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways |
| topic | Biomedical and clinical sciences Medical biotechnology Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Reproductive medicine Aryl hydrocarbon receptor CYP1A1/ CYP1B1 Chemoresistance Gynecological cancers Stemness markers Cancer stem cells |