Loss of the yeast transporter Agp2 upregulates the pleiotropic drug-resistant pump Pdr5 and confers resistance to the protein synthesis inhibitor cycloheximide

<p dir="ltr">The transmembrane protein Agp2, initially shown as a transporter of L-carnitine, mediates the high-affinity transport of polyamines and the anticancer drug bleomycin-A5. Cells lacking Agp2 are hyper-resistant to polyamine and bleomycin-A5. In these earlier studies, we sh...

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Bibliographic Details
Main Author:	Yusra Manzoor (18599180) (author)
Other Authors:	Mustapha Aouida (417652) (author), Ramya Ramadoss (16003318) (author), Balasubramanian Moovarkumudalvan (18300811) (author), Nisar Ahmed (584617) (author), Abdallah Alhaj Sulaiman (17777421) (author), Ashima Mohanty (18599183) (author), Reem Ali (9913494) (author), Borbala Mifsud (3907267) (author), Dindial Ramotar (208416) (author)
Published:	2024
Subjects:	Biological sciences Biochemistry and cell biology Genetics Biomedical and clinical sciences Medical biochemistry and metabolomics Mitochondria Gene expression Membrane proteins Protein expression Cell membranes Yeast Saccharomyces cerevisiae RNA analysis
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Loss of the yeast transporter Agp2 upregulates the pleiotropic drug-resistant pump Pdr5 and confers resistance to the protein synthesis inhibitor cycloheximide

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