Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice
<div><p>Accumulation of amyloid-β plaques and tau contribute to the pathogenesis of Alzheimer’s disease (AD), but it is unclear whether targeting tau pathology by antioxidants independently of amyloid-β causes beneficial effects on memory and neuropsychiatric symptoms. Selenium, an essen...
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2018
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| _version_ | 1864513513384312832 |
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| author | Ann Van der Jeugd (18629695) |
| author2 | Arnaldo Parra-Damas (230723) Raquel Baeta-Corral (18629698) Carlos M. Soto-Faguás (18629701) Tariq Ahmed (5768081) Frank M. LaFerla (11991116) Lydia Giménez-Llort (447668) Rudi D’Hooge (412153) Carlos A. Saura (11666536) |
| author2_role | author author author author author author author author |
| author_facet | Ann Van der Jeugd (18629695) Arnaldo Parra-Damas (230723) Raquel Baeta-Corral (18629698) Carlos M. Soto-Faguás (18629701) Tariq Ahmed (5768081) Frank M. LaFerla (11991116) Lydia Giménez-Llort (447668) Rudi D’Hooge (412153) Carlos A. Saura (11666536) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ann Van der Jeugd (18629695) Arnaldo Parra-Damas (230723) Raquel Baeta-Corral (18629698) Carlos M. Soto-Faguás (18629701) Tariq Ahmed (5768081) Frank M. LaFerla (11991116) Lydia Giménez-Llort (447668) Rudi D’Hooge (412153) Carlos A. Saura (11666536) |
| dc.date.none.fl_str_mv | 2018-04-24T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41598-018-24741-0 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Reversal_of_memory_and_neuropsychiatric_symptoms_and_reduced_tau_pathology_by_selenium_in_3xTg-AD_mice/25921051 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences Alzheimer's disease (AD) Amyloid-β plaques Tau pathology Neuropathology Selenium Antioxidants |
| dc.title.none.fl_str_mv | Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Accumulation of amyloid-β plaques and tau contribute to the pathogenesis of Alzheimer’s disease (AD), but it is unclear whether targeting tau pathology by antioxidants independently of amyloid-β causes beneficial effects on memory and neuropsychiatric symptoms. Selenium, an essential antioxidant element reduced in the aging brain, prevents development of neuropathology in AD transgenic mice at early disease stages. The therapeutic potential of selenium for ameliorating or reversing neuropsychiatric and cognitive behavioral symptoms at late AD stages is largely unknown. Here, we evaluated the effects of chronic dietary sodium selenate supplementation for 4 months in female 3xTg-AD mice at 12–14 months of age. Chronic sodium selenate treatment efficiently reversed hippocampal-dependent learning and memory impairments, and behavior- and neuropsychiatric-like symptoms in old female 3xTg-AD mice. Selenium significantly decreased the number of aggregated tau-positive neurons and astrogliosis, without globally affecting amyloid plaques, in the hippocampus of 3xTg-AD mice. These results indicate that selenium treatment reverses AD-like memory and neuropsychiatric symptoms by a mechanism involving reduction of aggregated tau and/or reactive astrocytes but not amyloid pathology. These results suggest that sodium selenate could be part of a combined therapeutic approach for the treatment of memory and neuropsychiatric symptoms in advanced AD stages.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Scientific Reports<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41598-018-24741-0" target="_blank">https://dx.doi.org/10.1038/s41598-018-24741-0</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_aa7f1ef3da3f84c115a30a982e6776a5 |
| identifier_str_mv | 10.1038/s41598-018-24741-0 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25921051 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD miceAnn Van der Jeugd (18629695)Arnaldo Parra-Damas (230723)Raquel Baeta-Corral (18629698)Carlos M. Soto-Faguás (18629701)Tariq Ahmed (5768081)Frank M. LaFerla (11991116)Lydia Giménez-Llort (447668)Rudi D’Hooge (412153)Carlos A. Saura (11666536)Biomedical and clinical sciencesNeurosciencesAlzheimer's disease (AD)Amyloid-β plaquesTau pathologyNeuropathologySeleniumAntioxidants<div><p>Accumulation of amyloid-β plaques and tau contribute to the pathogenesis of Alzheimer’s disease (AD), but it is unclear whether targeting tau pathology by antioxidants independently of amyloid-β causes beneficial effects on memory and neuropsychiatric symptoms. Selenium, an essential antioxidant element reduced in the aging brain, prevents development of neuropathology in AD transgenic mice at early disease stages. The therapeutic potential of selenium for ameliorating or reversing neuropsychiatric and cognitive behavioral symptoms at late AD stages is largely unknown. Here, we evaluated the effects of chronic dietary sodium selenate supplementation for 4 months in female 3xTg-AD mice at 12–14 months of age. Chronic sodium selenate treatment efficiently reversed hippocampal-dependent learning and memory impairments, and behavior- and neuropsychiatric-like symptoms in old female 3xTg-AD mice. Selenium significantly decreased the number of aggregated tau-positive neurons and astrogliosis, without globally affecting amyloid plaques, in the hippocampus of 3xTg-AD mice. These results indicate that selenium treatment reverses AD-like memory and neuropsychiatric symptoms by a mechanism involving reduction of aggregated tau and/or reactive astrocytes but not amyloid pathology. These results suggest that sodium selenate could be part of a combined therapeutic approach for the treatment of memory and neuropsychiatric symptoms in advanced AD stages.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Scientific Reports<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41598-018-24741-0" target="_blank">https://dx.doi.org/10.1038/s41598-018-24741-0</a></p>2018-04-24T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41598-018-24741-0https://figshare.com/articles/journal_contribution/Reversal_of_memory_and_neuropsychiatric_symptoms_and_reduced_tau_pathology_by_selenium_in_3xTg-AD_mice/25921051CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/259210512018-04-24T03:00:00Z |
| spellingShingle | Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice Ann Van der Jeugd (18629695) Biomedical and clinical sciences Neurosciences Alzheimer's disease (AD) Amyloid-β plaques Tau pathology Neuropathology Selenium Antioxidants |
| status_str | publishedVersion |
| title | Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice |
| title_full | Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice |
| title_fullStr | Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice |
| title_full_unstemmed | Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice |
| title_short | Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice |
| title_sort | Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice |
| topic | Biomedical and clinical sciences Neurosciences Alzheimer's disease (AD) Amyloid-β plaques Tau pathology Neuropathology Selenium Antioxidants |