Clinical Phenotyping and Multimodal Treatment of Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome From the Middle East and North Africa: Determining Treatment Outcomes and Predictors of Clinical Improvement
<h3>Objective</h3><p dir="ltr">To evaluate the effectiveness of UPOINT based multimodal treatment on patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), and determine factors that could be associated with clinical improvement.</p><h3>Meth...
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2022
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| _version_ | 1864513536162529280 |
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| author | Ahmad Majzoub (14058045) |
| author2 | Mohammed Mahdi (14058054) Ibrahim Khalil (375999) Ahmed Al Saeedi (17563068) Khalid Al Rumaihi (17563071) |
| author2_role | author author author author |
| author_facet | Ahmad Majzoub (14058045) Mohammed Mahdi (14058054) Ibrahim Khalil (375999) Ahmed Al Saeedi (17563068) Khalid Al Rumaihi (17563071) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ahmad Majzoub (14058045) Mohammed Mahdi (14058054) Ibrahim Khalil (375999) Ahmed Al Saeedi (17563068) Khalid Al Rumaihi (17563071) |
| dc.date.none.fl_str_mv | 2022-09-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.urology.2022.04.028 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Clinical_Phenotyping_and_Multimodal_Treatment_of_Men_With_Chronic_Prostatitis_Chronic_Pelvic_Pain_Syndrome_From_the_Middle_East_and_North_Africa_Determining_Treatment_Outcomes_and_Predictors_of_Clinical_Improvement/24745635 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Clinical Phenotyping Multimodal Treatment Men Chronic Prostatitis Chronic Pelvic Middle East North Africa |
| dc.title.none.fl_str_mv | Clinical Phenotyping and Multimodal Treatment of Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome From the Middle East and North Africa: Determining Treatment Outcomes and Predictors of Clinical Improvement |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Objective</h3><p dir="ltr">To evaluate the effectiveness of UPOINT based multimodal treatment on patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), and determine factors that could be associated with clinical improvement.</p><h3>Methods</h3><p dir="ltr">A retrospective study was conducted in Doha, Qatar including patients with CP/CPPS from the Middle East and North Africa. The UPOINT phenotyping system was used to classify patients and guide their multimodal therapy. NIH-CPSI scores were computed initially and after 3 months of treatment, and predictors of clinical improvement were assessed.</p><h3>Results</h3><p dir="ltr">The total NIH-CPSI improved significantly with a mean reduction of 8.21 after 3 months of treatment (P < .001). 66.2% of patients had a clinical improvement demonstrated as a total NIH-CPSI score reduction by at least 6 points after 3 months of treatment. No significant association was found between clinical improvement, and extent of pain (ORa = 1.198, 95% CI 0.392-3.662, P = .751), initial total NIH-CPSI (ORa = 0.983, 95% CI 0.886-1.089, P = .738), number of positive UPOINT domains (ORa = 0.871, 95% CI 0.451-1.681, P = .681), and number of prescribed therapies (ORa = 1.118, 95% CI 0.699-1.789, P = .641).</p><h3>Conclusion</h3><p dir="ltr">UPOINT phenotyping and directed therapy is associated with an important improvement in the CP/CPPS. Therapeutic response does not appear to related to age or ethnicity. Clinical improvement is also not predicted by initial extent and severity of the disease, whether relating to NIH-CPSI or the number of positive UPOINT phenotypes, neither to the number of therapies involved in the multimodal treatment strategy.</p><h2>Other Information</h2><p dir="ltr">Published in: Urology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.urology.2022.04.028" target="_blank">https://dx.doi.org/10.1016/j.urology.2022.04.028</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ab7a241e66dc2842e69837a2dbd699c3 |
| identifier_str_mv | 10.1016/j.urology.2022.04.028 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24745635 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Clinical Phenotyping and Multimodal Treatment of Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome From the Middle East and North Africa: Determining Treatment Outcomes and Predictors of Clinical ImprovementAhmad Majzoub (14058045)Mohammed Mahdi (14058054)Ibrahim Khalil (375999)Ahmed Al Saeedi (17563068)Khalid Al Rumaihi (17563071)Biomedical and clinical sciencesClinical sciencesClinical PhenotypingMultimodal TreatmentMenChronic ProstatitisChronic PelvicMiddle EastNorth Africa<h3>Objective</h3><p dir="ltr">To evaluate the effectiveness of UPOINT based multimodal treatment on patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), and determine factors that could be associated with clinical improvement.</p><h3>Methods</h3><p dir="ltr">A retrospective study was conducted in Doha, Qatar including patients with CP/CPPS from the Middle East and North Africa. The UPOINT phenotyping system was used to classify patients and guide their multimodal therapy. NIH-CPSI scores were computed initially and after 3 months of treatment, and predictors of clinical improvement were assessed.</p><h3>Results</h3><p dir="ltr">The total NIH-CPSI improved significantly with a mean reduction of 8.21 after 3 months of treatment (P < .001). 66.2% of patients had a clinical improvement demonstrated as a total NIH-CPSI score reduction by at least 6 points after 3 months of treatment. No significant association was found between clinical improvement, and extent of pain (ORa = 1.198, 95% CI 0.392-3.662, P = .751), initial total NIH-CPSI (ORa = 0.983, 95% CI 0.886-1.089, P = .738), number of positive UPOINT domains (ORa = 0.871, 95% CI 0.451-1.681, P = .681), and number of prescribed therapies (ORa = 1.118, 95% CI 0.699-1.789, P = .641).</p><h3>Conclusion</h3><p dir="ltr">UPOINT phenotyping and directed therapy is associated with an important improvement in the CP/CPPS. Therapeutic response does not appear to related to age or ethnicity. Clinical improvement is also not predicted by initial extent and severity of the disease, whether relating to NIH-CPSI or the number of positive UPOINT phenotypes, neither to the number of therapies involved in the multimodal treatment strategy.</p><h2>Other Information</h2><p dir="ltr">Published in: Urology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.urology.2022.04.028" target="_blank">https://dx.doi.org/10.1016/j.urology.2022.04.028</a></p>2022-09-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.urology.2022.04.028https://figshare.com/articles/journal_contribution/Clinical_Phenotyping_and_Multimodal_Treatment_of_Men_With_Chronic_Prostatitis_Chronic_Pelvic_Pain_Syndrome_From_the_Middle_East_and_North_Africa_Determining_Treatment_Outcomes_and_Predictors_of_Clinical_Improvement/24745635CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/247456352022-09-01T00:00:00Z |
| spellingShingle | Clinical Phenotyping and Multimodal Treatment of Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome From the Middle East and North Africa: Determining Treatment Outcomes and Predictors of Clinical Improvement Ahmad Majzoub (14058045) Biomedical and clinical sciences Clinical sciences Clinical Phenotyping Multimodal Treatment Men Chronic Prostatitis Chronic Pelvic Middle East North Africa |
| status_str | publishedVersion |
| title | Clinical Phenotyping and Multimodal Treatment of Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome From the Middle East and North Africa: Determining Treatment Outcomes and Predictors of Clinical Improvement |
| title_full | Clinical Phenotyping and Multimodal Treatment of Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome From the Middle East and North Africa: Determining Treatment Outcomes and Predictors of Clinical Improvement |
| title_fullStr | Clinical Phenotyping and Multimodal Treatment of Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome From the Middle East and North Africa: Determining Treatment Outcomes and Predictors of Clinical Improvement |
| title_full_unstemmed | Clinical Phenotyping and Multimodal Treatment of Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome From the Middle East and North Africa: Determining Treatment Outcomes and Predictors of Clinical Improvement |
| title_short | Clinical Phenotyping and Multimodal Treatment of Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome From the Middle East and North Africa: Determining Treatment Outcomes and Predictors of Clinical Improvement |
| title_sort | Clinical Phenotyping and Multimodal Treatment of Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome From the Middle East and North Africa: Determining Treatment Outcomes and Predictors of Clinical Improvement |
| topic | Biomedical and clinical sciences Clinical sciences Clinical Phenotyping Multimodal Treatment Men Chronic Prostatitis Chronic Pelvic Middle East North Africa |