Does COVID‐19 contribute to development of neurological disease?
<p></p><div> <h3> Background</h3> <p>Although coronavirus disease 2019 (COVID-19) has been associated primarily with pneumonia, recent data show that the causative agent of COVID-19, the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can...
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2023
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| _version_ | 1864513565258416128 |
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| author | Arehally M. Mahalakshmi (14778676) |
| author2 | Bipul Ray (14778679) Sunanda Tuladhar (14601228) Abid Bhat (14778682) Shasthara Paneyala (14778685) Duraisamy Patteswari (14778688) Meena Kishore Sakharkar (7348637) Hamdan Hamdan (662469) David M. Ojcius (7538189) Srinivasa Rao Bolla (9715874) Musthafa Mohamed Essa (7348646) Saravana Babu Chidambaram (7348649) M. Walid Qoronfleh (14153088) |
| author2_role | author author author author author author author author author author author author |
| author_facet | Arehally M. Mahalakshmi (14778676) Bipul Ray (14778679) Sunanda Tuladhar (14601228) Abid Bhat (14778682) Shasthara Paneyala (14778685) Duraisamy Patteswari (14778688) Meena Kishore Sakharkar (7348637) Hamdan Hamdan (662469) David M. Ojcius (7538189) Srinivasa Rao Bolla (9715874) Musthafa Mohamed Essa (7348646) Saravana Babu Chidambaram (7348649) M. Walid Qoronfleh (14153088) |
| author_role | author |
| dc.creator.none.fl_str_mv | Arehally M. Mahalakshmi (14778676) Bipul Ray (14778679) Sunanda Tuladhar (14601228) Abid Bhat (14778682) Shasthara Paneyala (14778685) Duraisamy Patteswari (14778688) Meena Kishore Sakharkar (7348637) Hamdan Hamdan (662469) David M. Ojcius (7538189) Srinivasa Rao Bolla (9715874) Musthafa Mohamed Essa (7348646) Saravana Babu Chidambaram (7348649) M. Walid Qoronfleh (14153088) |
| dc.date.none.fl_str_mv | 2023-03-16T06:23:26Z |
| dc.identifier.none.fl_str_mv | 10.1002/iid3.387 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Does_COVID_19_contribute_to_development_of_neurological_disease_/22258192 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Immunology Immunology and Allergy |
| dc.title.none.fl_str_mv | Does COVID‐19 contribute to development of neurological disease? |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p></p><div> <h3> Background</h3> <p>Although coronavirus disease 2019 (COVID-19) has been associated primarily with pneumonia, recent data show that the causative agent of COVID-19, the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can infect a large number of vital organs beyond the lungs, such as the heart, kidneys, and the brain. Thus, there is evidence showing possible retrograde transmission of the virus from the olfactory epithelium to regions of the brain stem.</p> <h3> Methods</h3> <p>This is a literature review article. The research design method is an evidence-based rapid review. The present discourse aim is first to scrutinize and assess the available literature on COVID-19 repercussion on the central nervous system (CNS). Standard literature and database searches were implemented, gathered relevant material, and extracted information was then assessed.</p> <h3> Results</h3> <p>The angiotensin-converting enzyme 2 (ACE2) receptors being the receptor for the virus, the threat to the central nervous system is expected. Neurons and glial cells express ACE2 receptors in the CNS, and recent studies suggest that activated glial cells contribute to neuroinflammation and the devastating effects of SARS-CoV-2 infection on the CNS. The SARS-CoV-2-induced immune-mediated demyelinating disease, cerebrovascular damage, neurodegeneration, and depression are some of the neurological complications discussed here.</p> <h3> Conclusion</h3> <p>This review correlates present clinical manifestations of COVID-19 patients with possible neurological consequences in the future, thus preparing healthcare providers for possible future consequences of COVID-19.</p> </div><p></p><h2>Other Information</h2> <p> Published in: Immunity, Inflammation and Disease<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1002/iid3.387" target="_blank">http://dx.doi.org/10.1002/iid3.387</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ac6e026a4afa6bf75664ee0aa540acac |
| identifier_str_mv | 10.1002/iid3.387 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22258192 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Does COVID‐19 contribute to development of neurological disease?Arehally M. Mahalakshmi (14778676)Bipul Ray (14778679)Sunanda Tuladhar (14601228)Abid Bhat (14778682)Shasthara Paneyala (14778685)Duraisamy Patteswari (14778688)Meena Kishore Sakharkar (7348637)Hamdan Hamdan (662469)David M. Ojcius (7538189)Srinivasa Rao Bolla (9715874)Musthafa Mohamed Essa (7348646)Saravana Babu Chidambaram (7348649)M. Walid Qoronfleh (14153088)Biomedical and clinical sciencesImmunologyImmunologyImmunology and Allergy<p></p><div> <h3> Background</h3> <p>Although coronavirus disease 2019 (COVID-19) has been associated primarily with pneumonia, recent data show that the causative agent of COVID-19, the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can infect a large number of vital organs beyond the lungs, such as the heart, kidneys, and the brain. Thus, there is evidence showing possible retrograde transmission of the virus from the olfactory epithelium to regions of the brain stem.</p> <h3> Methods</h3> <p>This is a literature review article. The research design method is an evidence-based rapid review. The present discourse aim is first to scrutinize and assess the available literature on COVID-19 repercussion on the central nervous system (CNS). Standard literature and database searches were implemented, gathered relevant material, and extracted information was then assessed.</p> <h3> Results</h3> <p>The angiotensin-converting enzyme 2 (ACE2) receptors being the receptor for the virus, the threat to the central nervous system is expected. Neurons and glial cells express ACE2 receptors in the CNS, and recent studies suggest that activated glial cells contribute to neuroinflammation and the devastating effects of SARS-CoV-2 infection on the CNS. The SARS-CoV-2-induced immune-mediated demyelinating disease, cerebrovascular damage, neurodegeneration, and depression are some of the neurological complications discussed here.</p> <h3> Conclusion</h3> <p>This review correlates present clinical manifestations of COVID-19 patients with possible neurological consequences in the future, thus preparing healthcare providers for possible future consequences of COVID-19.</p> </div><p></p><h2>Other Information</h2> <p> Published in: Immunity, Inflammation and Disease<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1002/iid3.387" target="_blank">http://dx.doi.org/10.1002/iid3.387</a></p>2023-03-16T06:23:26ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/iid3.387https://figshare.com/articles/journal_contribution/Does_COVID_19_contribute_to_development_of_neurological_disease_/22258192CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/222581922023-03-16T06:23:26Z |
| spellingShingle | Does COVID‐19 contribute to development of neurological disease? Arehally M. Mahalakshmi (14778676) Biomedical and clinical sciences Immunology Immunology Immunology and Allergy |
| status_str | publishedVersion |
| title | Does COVID‐19 contribute to development of neurological disease? |
| title_full | Does COVID‐19 contribute to development of neurological disease? |
| title_fullStr | Does COVID‐19 contribute to development of neurological disease? |
| title_full_unstemmed | Does COVID‐19 contribute to development of neurological disease? |
| title_short | Does COVID‐19 contribute to development of neurological disease? |
| title_sort | Does COVID‐19 contribute to development of neurological disease? |
| topic | Biomedical and clinical sciences Immunology Immunology Immunology and Allergy |