Experimental and computational investigation of the effect of Hsc70 structural variants on inhibiting amylin aggregation
<p>The misfolding and aggregation of human islet amyloid polypeptide (hIAPP), also known as amylin, have been implicated in the pathogenesis of type 2 diabetes (T2D). Heat shock proteins, specifically, heat shock cognate 70 (Hsc70), are molecular chaperones that protect against hIAPP misfoldin...
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2024
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