Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs
<h3>Purpose</h3><p dir="ltr">This study examines the effect of antihypertensive drugs on ACE2 and Angiotensin II levels in hypertensive COVID-19 patients.</p><h3>Introduction</h3><p dir="ltr">Hypertension is a common comorbidity among sev...
محفوظ في:
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| مؤلفون آخرون: | , , , , , , , , , , , , , , , , |
| منشور في: |
2022
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513547729371136 |
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| author | Mohamed A. Elrayess (21398687) |
| author2 | Hadeel T. Zedan (21398690) Rand A. Alattar (21398693) Hatem Abusriwil (12535524) Mahmoud Khatib A. A. Al-Ruweidi (12535527) Shamma Almuraikhy (12535530) Jabeed Parengal (12535533) Bassem Alhariri (9538578) Hadi M. Yassine (4675846) Ali A. Hssain (21398696) Arun Nair (401341) Musaed Al Samawi (12535539) Alaaeldin Abdelmajid (12535542) Jassim Al Suwaidi (284932) Mohamed Omar Saad (21398699) Muna Al-Maslamani (12184467) Ali S. Omrani (9590116) Huseyin C. Yalcin (6695099) |
| author2_role | author author author author author author author author author author author author author author author author author |
| author_facet | Mohamed A. Elrayess (21398687) Hadeel T. Zedan (21398690) Rand A. Alattar (21398693) Hatem Abusriwil (12535524) Mahmoud Khatib A. A. Al-Ruweidi (12535527) Shamma Almuraikhy (12535530) Jabeed Parengal (12535533) Bassem Alhariri (9538578) Hadi M. Yassine (4675846) Ali A. Hssain (21398696) Arun Nair (401341) Musaed Al Samawi (12535539) Alaaeldin Abdelmajid (12535542) Jassim Al Suwaidi (284932) Mohamed Omar Saad (21398699) Muna Al-Maslamani (12184467) Ali S. Omrani (9590116) Huseyin C. Yalcin (6695099) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mohamed A. Elrayess (21398687) Hadeel T. Zedan (21398690) Rand A. Alattar (21398693) Hatem Abusriwil (12535524) Mahmoud Khatib A. A. Al-Ruweidi (12535527) Shamma Almuraikhy (12535530) Jabeed Parengal (12535533) Bassem Alhariri (9538578) Hadi M. Yassine (4675846) Ali A. Hssain (21398696) Arun Nair (401341) Musaed Al Samawi (12535539) Alaaeldin Abdelmajid (12535542) Jassim Al Suwaidi (284932) Mohamed Omar Saad (21398699) Muna Al-Maslamani (12184467) Ali S. Omrani (9590116) Huseyin C. Yalcin (6695099) |
| dc.date.none.fl_str_mv | 2022-05-12T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1080/08037051.2022.2055530 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Soluble_ACE2_and_angiotensin_II_levels_are_modulated_in_hypertensive_COVID-19_patients_treated_with_different_antihypertension_drugs/29116886 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences Angiotensin II ACE2 ACEi COVID-19 hypertension |
| dc.title.none.fl_str_mv | Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Purpose</h3><p dir="ltr">This study examines the effect of antihypertensive drugs on ACE2 and Angiotensin II levels in hypertensive COVID-19 patients.</p><h3>Introduction</h3><p dir="ltr">Hypertension is a common comorbidity among severe COVID-19 patients. ACE2 expression can be modulated by antihypertensive drugs such as ACEis and ARBs, which may affect COVID-19's prognosis. BB and CCB reduce mortality, according to some evidence. Their effect on circulating levels of ACE2 and angiotensin II, as well as the severity of COVID-19, is less well studied.</p><h3>Materials and methods</h3><p dir="ltr">The clinical data were collected from 200 patients in four different antihypertensive medication classes (ACEi, ARB, BB, and CCB). Angiotensin II and ACE2 levels were determined using standard ELISA kits. ACE2, angiotensin II, and other clinical indices were evaluated by linear regression models.</p><h3>Results</h3><p dir="ltr">Patients on ACEi (<i>n</i> = 57), ARB (<i>n</i> = 68), BB (<i>n</i> = 15), or CCB (<i>n</i> = 30) in this study had mild (<i>n</i> = 76), moderate (<i>n</i> = 76), or severe (<i>n</i> = 52) COVID-19. ACE2 levels were higher in COVID-19 patients with severe disease (<i>p</i> = 0.04) than mild (<i>p</i> = 0.07) and moderate (<i>p</i> = 0.007). The length of hospital stay is correlated with ACE2 levels (<i>r </i>= 0.3, <i>p </i>= 0.003). Angiotensin II levels decreased with severity (<i>p</i> = 0.04). Higher ACE2 levels are associated with higher CRP and D-dimer levels. Elevated Angiotensin II was associated with low levels of CRP, D-dimer, and troponin. ACE2 levels increase with disease severity in patients taking an ARB (<i>p</i> = 0.01), patients taking ACEi, the degree of disease severity was associated with a decrease in angiotensin II. BB patients had the lowest disease severity.</p><h3>Conclusion</h3><p dir="ltr">We found different levels of soluble ACE2, and angiotensin II are observed among COVID-19 patients taking different antihypertensive medications and exhibiting varying levels of disease severity. COVID-19 severity increases with elevated ACE2 levels and lower angiotensin II levels indicating that BB treatment reduces severity regardless of levels of ACE2 and angiotensin II.</p><h2>Other Information</h2><p dir="ltr">Published in: Blood Pressure<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1080/08037051.2022.2055530" target="_blank">https://dx.doi.org/10.1080/08037051.2022.2055530</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ad80056d3da77b89ad27c54faebcc400 |
| identifier_str_mv | 10.1080/08037051.2022.2055530 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29116886 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugsMohamed A. Elrayess (21398687)Hadeel T. Zedan (21398690)Rand A. Alattar (21398693)Hatem Abusriwil (12535524)Mahmoud Khatib A. A. Al-Ruweidi (12535527)Shamma Almuraikhy (12535530)Jabeed Parengal (12535533)Bassem Alhariri (9538578)Hadi M. Yassine (4675846)Ali A. Hssain (21398696)Arun Nair (401341)Musaed Al Samawi (12535539)Alaaeldin Abdelmajid (12535542)Jassim Al Suwaidi (284932)Mohamed Omar Saad (21398699)Muna Al-Maslamani (12184467)Ali S. Omrani (9590116)Huseyin C. Yalcin (6695099)Biomedical and clinical sciencesCardiovascular medicine and haematologyPharmacology and pharmaceutical sciencesAngiotensin IIACE2ACEiCOVID-19hypertension<h3>Purpose</h3><p dir="ltr">This study examines the effect of antihypertensive drugs on ACE2 and Angiotensin II levels in hypertensive COVID-19 patients.</p><h3>Introduction</h3><p dir="ltr">Hypertension is a common comorbidity among severe COVID-19 patients. ACE2 expression can be modulated by antihypertensive drugs such as ACEis and ARBs, which may affect COVID-19's prognosis. BB and CCB reduce mortality, according to some evidence. Their effect on circulating levels of ACE2 and angiotensin II, as well as the severity of COVID-19, is less well studied.</p><h3>Materials and methods</h3><p dir="ltr">The clinical data were collected from 200 patients in four different antihypertensive medication classes (ACEi, ARB, BB, and CCB). Angiotensin II and ACE2 levels were determined using standard ELISA kits. ACE2, angiotensin II, and other clinical indices were evaluated by linear regression models.</p><h3>Results</h3><p dir="ltr">Patients on ACEi (<i>n</i> = 57), ARB (<i>n</i> = 68), BB (<i>n</i> = 15), or CCB (<i>n</i> = 30) in this study had mild (<i>n</i> = 76), moderate (<i>n</i> = 76), or severe (<i>n</i> = 52) COVID-19. ACE2 levels were higher in COVID-19 patients with severe disease (<i>p</i> = 0.04) than mild (<i>p</i> = 0.07) and moderate (<i>p</i> = 0.007). The length of hospital stay is correlated with ACE2 levels (<i>r </i>= 0.3, <i>p </i>= 0.003). Angiotensin II levels decreased with severity (<i>p</i> = 0.04). Higher ACE2 levels are associated with higher CRP and D-dimer levels. Elevated Angiotensin II was associated with low levels of CRP, D-dimer, and troponin. ACE2 levels increase with disease severity in patients taking an ARB (<i>p</i> = 0.01), patients taking ACEi, the degree of disease severity was associated with a decrease in angiotensin II. BB patients had the lowest disease severity.</p><h3>Conclusion</h3><p dir="ltr">We found different levels of soluble ACE2, and angiotensin II are observed among COVID-19 patients taking different antihypertensive medications and exhibiting varying levels of disease severity. COVID-19 severity increases with elevated ACE2 levels and lower angiotensin II levels indicating that BB treatment reduces severity regardless of levels of ACE2 and angiotensin II.</p><h2>Other Information</h2><p dir="ltr">Published in: Blood Pressure<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1080/08037051.2022.2055530" target="_blank">https://dx.doi.org/10.1080/08037051.2022.2055530</a></p>2022-05-12T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1080/08037051.2022.2055530https://figshare.com/articles/journal_contribution/Soluble_ACE2_and_angiotensin_II_levels_are_modulated_in_hypertensive_COVID-19_patients_treated_with_different_antihypertension_drugs/29116886CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/291168862022-05-12T09:00:00Z |
| spellingShingle | Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs Mohamed A. Elrayess (21398687) Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences Angiotensin II ACE2 ACEi COVID-19 hypertension |
| status_str | publishedVersion |
| title | Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs |
| title_full | Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs |
| title_fullStr | Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs |
| title_full_unstemmed | Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs |
| title_short | Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs |
| title_sort | Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences Angiotensin II ACE2 ACEi COVID-19 hypertension |