The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities
<p dir="ltr">Mycosis Fungoides (MF) and Sézary Syndrome (SS) belong to a wide spectrum of T cell lymphoproliferative disorders collectively termed cutaneous T cell lymphomas (CTCL). CTCLs represent an archetype of heterogeneous and dynamically variable lymphoproliferative neoplasms t...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2024
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| الموضوعات: | |
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| _version_ | 1864513539492806656 |
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| author | Kalyani Patil (2679424) |
| author2 | Gulab Sher (12984698) Shilpa Kuttikrishnan (3520079) Safwan Moton (17347027) Majid Alam (14158959) Joerg Buddenkotte (6293584) Aamir Ahmad (233201) Martin Steinhoff (5340194) Shahab Uddin (154400) |
| author2_role | author author author author author author author author |
| author_facet | Kalyani Patil (2679424) Gulab Sher (12984698) Shilpa Kuttikrishnan (3520079) Safwan Moton (17347027) Majid Alam (14158959) Joerg Buddenkotte (6293584) Aamir Ahmad (233201) Martin Steinhoff (5340194) Shahab Uddin (154400) |
| author_role | author |
| dc.creator.none.fl_str_mv | Kalyani Patil (2679424) Gulab Sher (12984698) Shilpa Kuttikrishnan (3520079) Safwan Moton (17347027) Majid Alam (14158959) Joerg Buddenkotte (6293584) Aamir Ahmad (233201) Martin Steinhoff (5340194) Shahab Uddin (154400) |
| dc.date.none.fl_str_mv | 2024-02-15T15:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.semcdb.2022.09.015 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_cross-talk_between_miRNAs_and_JAK_STAT_pathway_in_cutaneous_T_cell_lymphoma_Emphasis_on_therapeutic_opportunities/24516562 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Genetics Biomedical and clinical sciences Neurosciences Oncology and carcinogenesis Cutaneous T cell lymphoma Mycosis Fungoides Sézary Syndrome Epigenetics MiRNAs JAK/STAT pathway Therapeutics |
| dc.title.none.fl_str_mv | The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Mycosis Fungoides (MF) and Sézary Syndrome (SS) belong to a wide spectrum of T cell lymphoproliferative disorders collectively termed cutaneous T cell lymphomas (CTCL). CTCLs represent an archetype of heterogeneous and dynamically variable lymphoproliferative neoplasms typified by distinct clinical, histological, immunophenotypic, and genetic features. Owing to its complex dynamics, the pathogenesis of CTCL remains elusive. However, in recent years, progress in CTCL classification combined with next-generation sequencing analyses has broadened the genetic and epigenetic spectrum of clearly defined CTCL entities such as MF and SS. Several large-scale genome studies have identified the polygenic nature of CTCL and unveiled an idiosyncratic mutational landscape involving genetic aberrations, epigenetic alterations, cell cycle dysregulation, apoptosis, and the constitutive activation of T cell/NF-κB/JAK-STAT signaling pathways. In this review, we summarize the evolving insights on how the intrinsic epigenetic events driven by dysregulated miRNAs, including the oncogenic and tumor-suppressive miRNAs, influence the pathogenesis of MF and SS. We also focus on the interplay between the JAK/STAT pathway and miRNAs in CTCL as well as the significance of the miRNA/STAT axis as a relevant pathogenetic mechanism underlying CTCL initiation and progression. Based on these biologic insights, the current status and recent progress on novel therapies with a strong biological rationale, including miRNA-targeted molecules and JAK/STAT-targeted therapy for CTCL management, are discussed.</p><h2>Other Information</h2><p dir="ltr">Published in: Seminars in Cell & Developmental Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.semcdb.2022.09.015" target="_blank">https://dx.doi.org/10.1016/j.semcdb.2022.09.015</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ade4dd289fa7af548c8549619b363380 |
| identifier_str_mv | 10.1016/j.semcdb.2022.09.015 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24516562 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunitiesKalyani Patil (2679424)Gulab Sher (12984698)Shilpa Kuttikrishnan (3520079)Safwan Moton (17347027)Majid Alam (14158959)Joerg Buddenkotte (6293584)Aamir Ahmad (233201)Martin Steinhoff (5340194)Shahab Uddin (154400)Biological sciencesBiochemistry and cell biologyGeneticsBiomedical and clinical sciencesNeurosciencesOncology and carcinogenesisCutaneous T cell lymphomaMycosis FungoidesSézary SyndromeEpigeneticsMiRNAsJAK/STAT pathwayTherapeutics<p dir="ltr">Mycosis Fungoides (MF) and Sézary Syndrome (SS) belong to a wide spectrum of T cell lymphoproliferative disorders collectively termed cutaneous T cell lymphomas (CTCL). CTCLs represent an archetype of heterogeneous and dynamically variable lymphoproliferative neoplasms typified by distinct clinical, histological, immunophenotypic, and genetic features. Owing to its complex dynamics, the pathogenesis of CTCL remains elusive. However, in recent years, progress in CTCL classification combined with next-generation sequencing analyses has broadened the genetic and epigenetic spectrum of clearly defined CTCL entities such as MF and SS. Several large-scale genome studies have identified the polygenic nature of CTCL and unveiled an idiosyncratic mutational landscape involving genetic aberrations, epigenetic alterations, cell cycle dysregulation, apoptosis, and the constitutive activation of T cell/NF-κB/JAK-STAT signaling pathways. In this review, we summarize the evolving insights on how the intrinsic epigenetic events driven by dysregulated miRNAs, including the oncogenic and tumor-suppressive miRNAs, influence the pathogenesis of MF and SS. We also focus on the interplay between the JAK/STAT pathway and miRNAs in CTCL as well as the significance of the miRNA/STAT axis as a relevant pathogenetic mechanism underlying CTCL initiation and progression. Based on these biologic insights, the current status and recent progress on novel therapies with a strong biological rationale, including miRNA-targeted molecules and JAK/STAT-targeted therapy for CTCL management, are discussed.</p><h2>Other Information</h2><p dir="ltr">Published in: Seminars in Cell & Developmental Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.semcdb.2022.09.015" target="_blank">https://dx.doi.org/10.1016/j.semcdb.2022.09.015</a></p>2024-02-15T15:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.semcdb.2022.09.015https://figshare.com/articles/journal_contribution/The_cross-talk_between_miRNAs_and_JAK_STAT_pathway_in_cutaneous_T_cell_lymphoma_Emphasis_on_therapeutic_opportunities/24516562CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/245165622024-02-15T15:00:00Z |
| spellingShingle | The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities Kalyani Patil (2679424) Biological sciences Biochemistry and cell biology Genetics Biomedical and clinical sciences Neurosciences Oncology and carcinogenesis Cutaneous T cell lymphoma Mycosis Fungoides Sézary Syndrome Epigenetics MiRNAs JAK/STAT pathway Therapeutics |
| status_str | publishedVersion |
| title | The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities |
| title_full | The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities |
| title_fullStr | The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities |
| title_full_unstemmed | The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities |
| title_short | The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities |
| title_sort | The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities |
| topic | Biological sciences Biochemistry and cell biology Genetics Biomedical and clinical sciences Neurosciences Oncology and carcinogenesis Cutaneous T cell lymphoma Mycosis Fungoides Sézary Syndrome Epigenetics MiRNAs JAK/STAT pathway Therapeutics |