Hepatic and cardiac iron overload quantified by magnetic resonance imaging in patients on hemodialysis: A systematic review and meta‐analysis
<h3>Introduction</h3><p dir="ltr">Few studies have reported hepatic and cardiac iron overload in patients with end-stage renal disease (ESRD), and the current evidence regarding the prevalence is still scarce.</p><h3>Aim</h3><p dir="ltr">...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2022
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| الموضوعات: | |
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| _version_ | 1864513546023337984 |
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| author | Abdulqadir J. Nashwan (11659453) |
| author2 | Mohamed A. Yassin (8361183) Alaa Abd‐Alrazaq (14778511) Farag Shuweihdi (12573046) Muftah Othman (14777647) Hanan F. Abdul Rahim (9330201) Mujahed Shraim (633498) |
| author2_role | author author author author author author |
| author_facet | Abdulqadir J. Nashwan (11659453) Mohamed A. Yassin (8361183) Alaa Abd‐Alrazaq (14778511) Farag Shuweihdi (12573046) Muftah Othman (14777647) Hanan F. Abdul Rahim (9330201) Mujahed Shraim (633498) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdulqadir J. Nashwan (11659453) Mohamed A. Yassin (8361183) Alaa Abd‐Alrazaq (14778511) Farag Shuweihdi (12573046) Muftah Othman (14777647) Hanan F. Abdul Rahim (9330201) Mujahed Shraim (633498) |
| dc.date.none.fl_str_mv | 2022-11-17T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1111/hdi.13054 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Hepatic_and_cardiac_iron_overload_quantified_by_magnetic_resonance_imaging_in_patients_on_hemodialysis_A_systematic_review_and_meta_analysis/29413424 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences end-stage renal disease heart hemodialysis iron overload liver meta-analysis systematic review T2*MRI |
| dc.title.none.fl_str_mv | Hepatic and cardiac iron overload quantified by magnetic resonance imaging in patients on hemodialysis: A systematic review and meta‐analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Introduction</h3><p dir="ltr">Few studies have reported hepatic and cardiac iron overload in patients with end-stage renal disease (ESRD), and the current evidence regarding the prevalence is still scarce.</p><h3>Aim</h3><p dir="ltr">This review aims to estimate the prevalence of hepatic and/or cardiac iron overload quantified by magnetic resonance imaging (MRI) in patients with ESRD who receive hemodialysis (HD), peritoneal dialysis (PD), or have undergone a kidney transplant.</p><h3>Methods</h3><p dir="ltr">A systematic review with meta-analysis was conducted and reported in line with PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. MEDLINE and Embase bibliographic databases were searched using a comprehensive list of controlled vocabulary and keywords to identify relevant studies. All studies reporting the prevalence of hepatic and/or cardiac iron overload quantified by MRI in ESRD patients were considered. The Newcastle-Ottawa scale was used to assess the methodological quality of included studies. To investigate the heterogeneity between studies, random-effect meta-analyses for proportions were used.</p><h3>Results</h3><p dir="ltr">The review comprised seven studies that included 339 patients. Using meta-analysis, the pooled prevalence of severe and mild to moderate hepatic iron overload quantified by MRI was 0.23 [95% CI: 0.08–0.43] and 0.52 [95% CI: 0.47–0.57], respectively. Only three studies included cardiac iron quantification, and none reported iron overload.</p><h3>Conclusions</h3><p dir="ltr">This review has revealed a high prevalence of severe hepatic iron overload in patients with ESRD treated by HD. Further studies with a larger sample size are needed to determine the impact of iron overload on vital organs in patients with ESRD and guide future research in this understudied field. Proper use of iron chelation and continuous monitoring will help in the early detection of unsolicited complications; however, the low renal clearance of most iron chelators limits the options for treating iron excess in patients with ESRD.</p><h2>Other Information</h2><p dir="ltr">Published in: Hemodialysis International<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/hdi.13054" target="_blank">https://dx.doi.org/10.1111/hdi.13054</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ae9fa488350897937f37b514b6ea1b23 |
| identifier_str_mv | 10.1111/hdi.13054 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29413424 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Hepatic and cardiac iron overload quantified by magnetic resonance imaging in patients on hemodialysis: A systematic review and meta‐analysisAbdulqadir J. Nashwan (11659453)Mohamed A. Yassin (8361183)Alaa Abd‐Alrazaq (14778511)Farag Shuweihdi (12573046)Muftah Othman (14777647)Hanan F. Abdul Rahim (9330201)Mujahed Shraim (633498)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesend-stage renal diseasehearthemodialysisiron overloadlivermeta-analysissystematic reviewT2*MRI<h3>Introduction</h3><p dir="ltr">Few studies have reported hepatic and cardiac iron overload in patients with end-stage renal disease (ESRD), and the current evidence regarding the prevalence is still scarce.</p><h3>Aim</h3><p dir="ltr">This review aims to estimate the prevalence of hepatic and/or cardiac iron overload quantified by magnetic resonance imaging (MRI) in patients with ESRD who receive hemodialysis (HD), peritoneal dialysis (PD), or have undergone a kidney transplant.</p><h3>Methods</h3><p dir="ltr">A systematic review with meta-analysis was conducted and reported in line with PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. MEDLINE and Embase bibliographic databases were searched using a comprehensive list of controlled vocabulary and keywords to identify relevant studies. All studies reporting the prevalence of hepatic and/or cardiac iron overload quantified by MRI in ESRD patients were considered. The Newcastle-Ottawa scale was used to assess the methodological quality of included studies. To investigate the heterogeneity between studies, random-effect meta-analyses for proportions were used.</p><h3>Results</h3><p dir="ltr">The review comprised seven studies that included 339 patients. Using meta-analysis, the pooled prevalence of severe and mild to moderate hepatic iron overload quantified by MRI was 0.23 [95% CI: 0.08–0.43] and 0.52 [95% CI: 0.47–0.57], respectively. Only three studies included cardiac iron quantification, and none reported iron overload.</p><h3>Conclusions</h3><p dir="ltr">This review has revealed a high prevalence of severe hepatic iron overload in patients with ESRD treated by HD. Further studies with a larger sample size are needed to determine the impact of iron overload on vital organs in patients with ESRD and guide future research in this understudied field. Proper use of iron chelation and continuous monitoring will help in the early detection of unsolicited complications; however, the low renal clearance of most iron chelators limits the options for treating iron excess in patients with ESRD.</p><h2>Other Information</h2><p dir="ltr">Published in: Hemodialysis International<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/hdi.13054" target="_blank">https://dx.doi.org/10.1111/hdi.13054</a></p>2022-11-17T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1111/hdi.13054https://figshare.com/articles/journal_contribution/Hepatic_and_cardiac_iron_overload_quantified_by_magnetic_resonance_imaging_in_patients_on_hemodialysis_A_systematic_review_and_meta_analysis/29413424CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/294134242022-11-17T09:00:00Z |
| spellingShingle | Hepatic and cardiac iron overload quantified by magnetic resonance imaging in patients on hemodialysis: A systematic review and meta‐analysis Abdulqadir J. Nashwan (11659453) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences end-stage renal disease heart hemodialysis iron overload liver meta-analysis systematic review T2*MRI |
| status_str | publishedVersion |
| title | Hepatic and cardiac iron overload quantified by magnetic resonance imaging in patients on hemodialysis: A systematic review and meta‐analysis |
| title_full | Hepatic and cardiac iron overload quantified by magnetic resonance imaging in patients on hemodialysis: A systematic review and meta‐analysis |
| title_fullStr | Hepatic and cardiac iron overload quantified by magnetic resonance imaging in patients on hemodialysis: A systematic review and meta‐analysis |
| title_full_unstemmed | Hepatic and cardiac iron overload quantified by magnetic resonance imaging in patients on hemodialysis: A systematic review and meta‐analysis |
| title_short | Hepatic and cardiac iron overload quantified by magnetic resonance imaging in patients on hemodialysis: A systematic review and meta‐analysis |
| title_sort | Hepatic and cardiac iron overload quantified by magnetic resonance imaging in patients on hemodialysis: A systematic review and meta‐analysis |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences end-stage renal disease heart hemodialysis iron overload liver meta-analysis systematic review T2*MRI |