Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review
<p dir="ltr">The ongoing COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a globally leading public health concern over the past two years. Despite the development and administration of multiple vaccines, the mutation of newer strai...
محفوظ في:
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2021
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إضافة وسم
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| _version_ | 1864513512400748544 |
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| author | Ridhima Kaul (12485902) |
| author2 | Pradipta Paul (12628162) Sanjay Kumar (8853) Dietrich Büsselberg (11008857) Vivek Dhar Dwivedi (8504640) Ali Chaari (827168) |
| author2_role | author author author author author |
| author_facet | Ridhima Kaul (12485902) Pradipta Paul (12628162) Sanjay Kumar (8853) Dietrich Büsselberg (11008857) Vivek Dhar Dwivedi (8504640) Ali Chaari (827168) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ridhima Kaul (12485902) Pradipta Paul (12628162) Sanjay Kumar (8853) Dietrich Büsselberg (11008857) Vivek Dhar Dwivedi (8504640) Ali Chaari (827168) |
| dc.date.none.fl_str_mv | 2021-10-14T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/ijms222011069 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Promising_Antiviral_Activities_of_Natural_Flavonoids_against_SARS-CoV-2_Targets_Systematic_Review/26095633 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Microbiology Biomedical and clinical sciences Medical microbiology Pharmacology and pharmaceutical sciences flavonoids coronavirus SARS-CoV-2 SARS-CoV MERS-CoV |
| dc.title.none.fl_str_mv | Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The ongoing COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a globally leading public health concern over the past two years. Despite the development and administration of multiple vaccines, the mutation of newer strains and challenges to universal immunity has shifted the focus to the lack of efficacious drugs for therapeutic intervention for the disease. As with SARS-CoV, MERS-CoV, and other non-respiratory viruses, flavonoids present themselves as a promising therapeutic intervention given their success in silico, in vitro, in vivo, and more recently, in clinical studies. This review focuses on data from in vitro studies analyzing the effects of flavonoids on various key SARS-CoV-2 targets and presents an analysis of the structure-activity relationships for the same. From 27 primary papers, over 69 flavonoids were investigated for their activities against various SARS-CoV-2 targets, ranging from the promising 3C-like protease (3CLpro) to the less explored nucleocapsid (N) protein; the most promising were quercetin and myricetin derivatives, baicalein, baicalin, EGCG, and tannic acid. We further review promising in silico studies featuring activities of flavonoids against SARS-CoV-2 and list ongoing clinical studies involving the therapeutic potential of flavonoid-rich extracts in combination with synthetic drugs or other polyphenols and suggest prospects for the future of flavonoids against SARS-CoV-2.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Molecular Sciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms222011069" target="_blank">https://dx.doi.org/10.3390/ijms222011069</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_aeafd029a61bfc61a38ba2a38aa8df5f |
| identifier_str_mv | 10.3390/ijms222011069 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26095633 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic ReviewRidhima Kaul (12485902)Pradipta Paul (12628162)Sanjay Kumar (8853)Dietrich Büsselberg (11008857)Vivek Dhar Dwivedi (8504640)Ali Chaari (827168)Biological sciencesMicrobiologyBiomedical and clinical sciencesMedical microbiologyPharmacology and pharmaceutical sciencesflavonoidscoronavirusSARS-CoV-2SARS-CoVMERS-CoV<p dir="ltr">The ongoing COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a globally leading public health concern over the past two years. Despite the development and administration of multiple vaccines, the mutation of newer strains and challenges to universal immunity has shifted the focus to the lack of efficacious drugs for therapeutic intervention for the disease. As with SARS-CoV, MERS-CoV, and other non-respiratory viruses, flavonoids present themselves as a promising therapeutic intervention given their success in silico, in vitro, in vivo, and more recently, in clinical studies. This review focuses on data from in vitro studies analyzing the effects of flavonoids on various key SARS-CoV-2 targets and presents an analysis of the structure-activity relationships for the same. From 27 primary papers, over 69 flavonoids were investigated for their activities against various SARS-CoV-2 targets, ranging from the promising 3C-like protease (3CLpro) to the less explored nucleocapsid (N) protein; the most promising were quercetin and myricetin derivatives, baicalein, baicalin, EGCG, and tannic acid. We further review promising in silico studies featuring activities of flavonoids against SARS-CoV-2 and list ongoing clinical studies involving the therapeutic potential of flavonoid-rich extracts in combination with synthetic drugs or other polyphenols and suggest prospects for the future of flavonoids against SARS-CoV-2.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Molecular Sciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms222011069" target="_blank">https://dx.doi.org/10.3390/ijms222011069</a></p>2021-10-14T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/ijms222011069https://figshare.com/articles/journal_contribution/Promising_Antiviral_Activities_of_Natural_Flavonoids_against_SARS-CoV-2_Targets_Systematic_Review/26095633CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/260956332021-10-14T06:00:00Z |
| spellingShingle | Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review Ridhima Kaul (12485902) Biological sciences Microbiology Biomedical and clinical sciences Medical microbiology Pharmacology and pharmaceutical sciences flavonoids coronavirus SARS-CoV-2 SARS-CoV MERS-CoV |
| status_str | publishedVersion |
| title | Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review |
| title_full | Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review |
| title_fullStr | Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review |
| title_full_unstemmed | Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review |
| title_short | Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review |
| title_sort | Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review |
| topic | Biological sciences Microbiology Biomedical and clinical sciences Medical microbiology Pharmacology and pharmaceutical sciences flavonoids coronavirus SARS-CoV-2 SARS-CoV MERS-CoV |