Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review
<h3>Background and Aims</h3><p dir="ltr">Chronic kidney disease (CKD) patients undergoing peritoneal dialysis (PD) are susceptible to complications, including iron overload, which can significantly impact their prognosis and overall health. This scoping review aimed to st...
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2024
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| author | Abdulqadir J. Nashwan (11659453) |
| author2 | Mohammad T. Abuawwad (17632242) Jaber H. Jaradat (21632849) Anas Ibraheem (22047821) Mohamed A. Yassin (8361183) Mohammad J. J. Taha (17908127) |
| author2_role | author author author author author |
| author_facet | Abdulqadir J. Nashwan (11659453) Mohammad T. Abuawwad (17632242) Jaber H. Jaradat (21632849) Anas Ibraheem (22047821) Mohamed A. Yassin (8361183) Mohammad J. J. Taha (17908127) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdulqadir J. Nashwan (11659453) Mohammad T. Abuawwad (17632242) Jaber H. Jaradat (21632849) Anas Ibraheem (22047821) Mohamed A. Yassin (8361183) Mohammad J. J. Taha (17908127) |
| dc.date.none.fl_str_mv | 2024-09-08T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/hsr2.2255 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Prevalence_of_iron_overload_in_patients_with_chronic_kidney_disease_on_peritoneal_dialysis_A_scoping_review/29900672 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences chelating chronic kidney disease ferritin iron overload peritoneal dialysis |
| dc.title.none.fl_str_mv | Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background and Aims</h3><p dir="ltr">Chronic kidney disease (CKD) patients undergoing peritoneal dialysis (PD) are susceptible to complications, including iron overload, which can significantly impact their prognosis and overall health. This scoping review aimed to study the prevalence and implications of iron overload in CKD patients undergoing PD.</p><h3>Methods</h3><p dir="ltr">A comprehensive search was conducted across five databases, leading to the selection of 18 papers for in‐depth analysis. These studies collectively involved 381 PD patients, 60.3% were males.</p><h3>Results</h3><p dir="ltr">No consensus was reached regarding the exact diagnostic cutoff for iron overload. The investigations revealed four main aspects: (1) Seven papers identified various factors contributing to iron overload, emphasizing the role of different iron supplements and magnetic resonance imaging's capability to diagnose iron accumulation in organs; (2) Iron overload in young patients was found to hinder growth; (3) Six studies highlighted the adverse effects of iron overload, with cardiac issues being the most significant; (4) Three studies demonstrated the efficacy of iron‐chelating agents, Deferoxamine and Deferasirox, in treating iron overload patients undergoing PD. Overall, the estimated prevalence of liver iron overload in CKD patients on PD ranges from approximately 10% to 28.6%, which is far lower than the prevalence of 75% elegantly shown in HD patients.</p><h3>Conclusion</h3><p dir="ltr">While iron overload was a significant concern for CKD patients undergoing PD in the past, it is less common in the current era due to advancements in treatments, such as erythropoiesis‐stimulating agents. Treatment with specific chelation agents has proven beneficial, but there is also a risk of adverse effects, necessitating meticulous monitoring and timely intervention.</p><h2>Other Information</h2><p dir="ltr">Published in: Health Science Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/hsr2.2255" target="_blank">https://dx.doi.org/10.1002/hsr2.2255</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_aef6701444118a73e2473c438e9f9ac7 |
| identifier_str_mv | 10.1002/hsr2.2255 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29900672 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping reviewAbdulqadir J. Nashwan (11659453)Mohammad T. Abuawwad (17632242)Jaber H. Jaradat (21632849)Anas Ibraheem (22047821)Mohamed A. Yassin (8361183)Mohammad J. J. Taha (17908127)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical scienceschelatingchronic kidney diseaseferritiniron overloadperitoneal dialysis<h3>Background and Aims</h3><p dir="ltr">Chronic kidney disease (CKD) patients undergoing peritoneal dialysis (PD) are susceptible to complications, including iron overload, which can significantly impact their prognosis and overall health. This scoping review aimed to study the prevalence and implications of iron overload in CKD patients undergoing PD.</p><h3>Methods</h3><p dir="ltr">A comprehensive search was conducted across five databases, leading to the selection of 18 papers for in‐depth analysis. These studies collectively involved 381 PD patients, 60.3% were males.</p><h3>Results</h3><p dir="ltr">No consensus was reached regarding the exact diagnostic cutoff for iron overload. The investigations revealed four main aspects: (1) Seven papers identified various factors contributing to iron overload, emphasizing the role of different iron supplements and magnetic resonance imaging's capability to diagnose iron accumulation in organs; (2) Iron overload in young patients was found to hinder growth; (3) Six studies highlighted the adverse effects of iron overload, with cardiac issues being the most significant; (4) Three studies demonstrated the efficacy of iron‐chelating agents, Deferoxamine and Deferasirox, in treating iron overload patients undergoing PD. Overall, the estimated prevalence of liver iron overload in CKD patients on PD ranges from approximately 10% to 28.6%, which is far lower than the prevalence of 75% elegantly shown in HD patients.</p><h3>Conclusion</h3><p dir="ltr">While iron overload was a significant concern for CKD patients undergoing PD in the past, it is less common in the current era due to advancements in treatments, such as erythropoiesis‐stimulating agents. Treatment with specific chelation agents has proven beneficial, but there is also a risk of adverse effects, necessitating meticulous monitoring and timely intervention.</p><h2>Other Information</h2><p dir="ltr">Published in: Health Science Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/hsr2.2255" target="_blank">https://dx.doi.org/10.1002/hsr2.2255</a></p>2024-09-08T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/hsr2.2255https://figshare.com/articles/journal_contribution/Prevalence_of_iron_overload_in_patients_with_chronic_kidney_disease_on_peritoneal_dialysis_A_scoping_review/29900672CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/299006722024-09-08T03:00:00Z |
| spellingShingle | Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review Abdulqadir J. Nashwan (11659453) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences chelating chronic kidney disease ferritin iron overload peritoneal dialysis |
| status_str | publishedVersion |
| title | Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review |
| title_full | Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review |
| title_fullStr | Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review |
| title_full_unstemmed | Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review |
| title_short | Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review |
| title_sort | Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences chelating chronic kidney disease ferritin iron overload peritoneal dialysis |