Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection?
<h3>Background</h3><p dir="ltr">The SARS-CoV-2 coronavirus gains entry to target cells via the angiotensin-converting enzyme 2 (ACE2) receptor present on cells in blood vessels, lungs, heart, intestines, and kidneys. Renin-Angiotensin System (RAS) overactivity has also be...
محفوظ في:
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| مؤلفون آخرون: | , , |
| منشور في: |
2020
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| _version_ | 1864513558887268352 |
|---|---|
| author | Abu Saleh Md Moin (6189512) |
| author2 | Thozhukat Sathyapalan (704787) Stephen L. Atkin (6684368) Alexandra E. Butler (6189536) |
| author2_role | author author author |
| author_facet | Abu Saleh Md Moin (6189512) Thozhukat Sathyapalan (704787) Stephen L. Atkin (6684368) Alexandra E. Butler (6189536) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abu Saleh Md Moin (6189512) Thozhukat Sathyapalan (704787) Stephen L. Atkin (6684368) Alexandra E. Butler (6189536) |
| dc.date.none.fl_str_mv | 2020-09-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.metop.2020.100052 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Renin-Angiotensin_System_overactivation_in_polycystic_ovary_syndrome_a_risk_for_SARS-CoV-2_infection_/24249847 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Reproductive medicine ACE2 protein Polycystic ovary syndrome Renin Angiotensinogen |
| dc.title.none.fl_str_mv | Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection? |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">The SARS-CoV-2 coronavirus gains entry to target cells via the angiotensin-converting enzyme 2 (ACE2) receptor present on cells in blood vessels, lungs, heart, intestines, and kidneys. Renin-Angiotensin System (RAS) overactivity has also been described in metabolic syndrome, type 2 diabetes (T2D) and obesity, conditions shared by women with polycystic ovary syndrome (PCOS) We hypothesized that RAS overactivity may be present in PCOS.</p><h3>Methods</h3><p dir="ltr">We determined plasma levels of RAS-related proteins in a cohort of age matched control women (n = 97) and women with PCOS (n = 146). Plasma levels of RAS-related proteins (ACE2, Renin and Angiotensinogen (AGT)) were determined by Slow Off-rate Modified Aptamer (SOMA)-scan plasma protein measurement.</p><h3>Results</h3><p dir="ltr">PCOS women had a higher BMI (p < 0.001), systolic (p < 0.0001) and diastolic (p < 0.05) blood pressure, waist circumference (p < 0.0001), testosterone (p < 0.0001), free androgen index (p < 0.0001) and CRP (p < 0.0001). Renin was elevated in PCOS (p < 0.05) and angiotensinogen was lower in PCOS (p < 0.05), indicating overactivity of the RAS system in PCOS. ACE2 levels were lower in PCOS (p < 0.05), suggesting that PCOS women are at risk for development of hypertension.</p><h3>Conclusion</h3><p dir="ltr">RAS proteins levels differed between PCOS and control women, suggesting that the insulin resistance inherent in PCOS may predispose these women to more severe COVID-19 infection.</p><h2>Other Information</h2><p dir="ltr">Published in: Metabolism Open<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.metop.2020.100052" target="_blank">https://dx.doi.org/10.1016/j.metop.2020.100052</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_af09deced0407b6225b07a717d68e482 |
| identifier_str_mv | 10.1016/j.metop.2020.100052 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24249847 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection?Abu Saleh Md Moin (6189512)Thozhukat Sathyapalan (704787)Stephen L. Atkin (6684368)Alexandra E. Butler (6189536)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesReproductive medicineACE2 proteinPolycystic ovary syndromeReninAngiotensinogen<h3>Background</h3><p dir="ltr">The SARS-CoV-2 coronavirus gains entry to target cells via the angiotensin-converting enzyme 2 (ACE2) receptor present on cells in blood vessels, lungs, heart, intestines, and kidneys. Renin-Angiotensin System (RAS) overactivity has also been described in metabolic syndrome, type 2 diabetes (T2D) and obesity, conditions shared by women with polycystic ovary syndrome (PCOS) We hypothesized that RAS overactivity may be present in PCOS.</p><h3>Methods</h3><p dir="ltr">We determined plasma levels of RAS-related proteins in a cohort of age matched control women (n = 97) and women with PCOS (n = 146). Plasma levels of RAS-related proteins (ACE2, Renin and Angiotensinogen (AGT)) were determined by Slow Off-rate Modified Aptamer (SOMA)-scan plasma protein measurement.</p><h3>Results</h3><p dir="ltr">PCOS women had a higher BMI (p < 0.001), systolic (p < 0.0001) and diastolic (p < 0.05) blood pressure, waist circumference (p < 0.0001), testosterone (p < 0.0001), free androgen index (p < 0.0001) and CRP (p < 0.0001). Renin was elevated in PCOS (p < 0.05) and angiotensinogen was lower in PCOS (p < 0.05), indicating overactivity of the RAS system in PCOS. ACE2 levels were lower in PCOS (p < 0.05), suggesting that PCOS women are at risk for development of hypertension.</p><h3>Conclusion</h3><p dir="ltr">RAS proteins levels differed between PCOS and control women, suggesting that the insulin resistance inherent in PCOS may predispose these women to more severe COVID-19 infection.</p><h2>Other Information</h2><p dir="ltr">Published in: Metabolism Open<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.metop.2020.100052" target="_blank">https://dx.doi.org/10.1016/j.metop.2020.100052</a></p>2020-09-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.metop.2020.100052https://figshare.com/articles/journal_contribution/Renin-Angiotensin_System_overactivation_in_polycystic_ovary_syndrome_a_risk_for_SARS-CoV-2_infection_/24249847CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/242498472020-09-01T00:00:00Z |
| spellingShingle | Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection? Abu Saleh Md Moin (6189512) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Reproductive medicine ACE2 protein Polycystic ovary syndrome Renin Angiotensinogen |
| status_str | publishedVersion |
| title | Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection? |
| title_full | Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection? |
| title_fullStr | Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection? |
| title_full_unstemmed | Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection? |
| title_short | Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection? |
| title_sort | Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection? |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Reproductive medicine ACE2 protein Polycystic ovary syndrome Renin Angiotensinogen |