Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting
<p dir="ltr">Recent years have seen significant efforts in understanding and modulating the immune response in cancer. In this context, immunosuppressive cells, including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), have come under intense investigation fo...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | |
| منشور في: |
2016
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513556431503360 |
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| author | Belal Chaudhary (19738021) |
| author2 | Eyad Elkord (5396390) |
| author2_role | author |
| author_facet | Belal Chaudhary (19738021) Eyad Elkord (5396390) |
| author_role | author |
| dc.creator.none.fl_str_mv | Belal Chaudhary (19738021) Eyad Elkord (5396390) |
| dc.date.none.fl_str_mv | 2016-08-06T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/vaccines4030028 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Regulatory_T_Cells_in_the_Tumor_Microenvironment_and_Cancer_Progression_Role_and_Therapeutic_Targeting/27101614 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Oncology and carcinogenesis regulatory T cells tumor microenvironment cancer progression therapeutic targeting tumor-infiltrating lymphocytes |
| dc.title.none.fl_str_mv | Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Recent years have seen significant efforts in understanding and modulating the immune response in cancer. In this context, immunosuppressive cells, including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), have come under intense investigation for their proposed roles in suppressing tumor-specific immune responses and establishing an immunosuppressive tumor microenvironment, thus enabling tumor immune evasion. Additionally, recent evidence indicates that Tregs comprise diverse and heterogeneous subsets; phenotypically and functionally distinct subsets of tumor-infiltrating Tregs could contribute differently to cancer prognosis and clinical outcomes. Understanding Treg biology in the setting of cancer, and specifically the tumor microenvironment, is important for designing effective cancer therapies. In this review, we critically examine the role of Tregs in the tumor microenvironment and in cancer progression focusing on human studies. We also discuss the impact of current therapeutic modalities on Treg biology and the therapeutic opportunities for targeting Tregs to enhance anti-tumor immune responses and clinical benefits.</p><h2>Other Information</h2><p dir="ltr">Published in: Vaccines<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/vaccines4030028" target="_blank">https://dx.doi.org/10.3390/vaccines4030028</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_af5e510d1c2d78597e789f7b9917cfed |
| identifier_str_mv | 10.3390/vaccines4030028 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27101614 |
| publishDate | 2016 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic TargetingBelal Chaudhary (19738021)Eyad Elkord (5396390)Biomedical and clinical sciencesImmunologyOncology and carcinogenesisregulatory T cellstumor microenvironmentcancer progressiontherapeutic targetingtumor-infiltrating lymphocytes<p dir="ltr">Recent years have seen significant efforts in understanding and modulating the immune response in cancer. In this context, immunosuppressive cells, including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), have come under intense investigation for their proposed roles in suppressing tumor-specific immune responses and establishing an immunosuppressive tumor microenvironment, thus enabling tumor immune evasion. Additionally, recent evidence indicates that Tregs comprise diverse and heterogeneous subsets; phenotypically and functionally distinct subsets of tumor-infiltrating Tregs could contribute differently to cancer prognosis and clinical outcomes. Understanding Treg biology in the setting of cancer, and specifically the tumor microenvironment, is important for designing effective cancer therapies. In this review, we critically examine the role of Tregs in the tumor microenvironment and in cancer progression focusing on human studies. We also discuss the impact of current therapeutic modalities on Treg biology and the therapeutic opportunities for targeting Tregs to enhance anti-tumor immune responses and clinical benefits.</p><h2>Other Information</h2><p dir="ltr">Published in: Vaccines<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/vaccines4030028" target="_blank">https://dx.doi.org/10.3390/vaccines4030028</a></p>2016-08-06T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/vaccines4030028https://figshare.com/articles/journal_contribution/Regulatory_T_Cells_in_the_Tumor_Microenvironment_and_Cancer_Progression_Role_and_Therapeutic_Targeting/27101614CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/271016142016-08-06T03:00:00Z |
| spellingShingle | Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting Belal Chaudhary (19738021) Biomedical and clinical sciences Immunology Oncology and carcinogenesis regulatory T cells tumor microenvironment cancer progression therapeutic targeting tumor-infiltrating lymphocytes |
| status_str | publishedVersion |
| title | Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting |
| title_full | Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting |
| title_fullStr | Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting |
| title_full_unstemmed | Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting |
| title_short | Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting |
| title_sort | Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting |
| topic | Biomedical and clinical sciences Immunology Oncology and carcinogenesis regulatory T cells tumor microenvironment cancer progression therapeutic targeting tumor-infiltrating lymphocytes |