Role of HMGB1 and its associated signaling pathways in human malignancies
<p dir="ltr">The High-Mobility Group Box-1 (HMGB1), a non-histone chromatin-associated protein, plays a crucial role in cancer growth and response to therapy as it retains a pivotal role in promoting both cell death and survival. HMGB1 has been reported to regulate several signaling...
محفوظ في:
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2023
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| _version_ | 1864513539462397952 |
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| author | Sourour Idoudi (14153457) |
| author2 | Takwa Bedhiafi (14153460) Shona Pedersen (2792278) Mohamed Elahtem (17431002) Izzaldin Alremawi (17431005) Sabah Akhtar (5809925) Said Dermime (79420) Maysaloun Merhi (4246147) Shahab Uddin (154400) |
| author2_role | author author author author author author author author |
| author_facet | Sourour Idoudi (14153457) Takwa Bedhiafi (14153460) Shona Pedersen (2792278) Mohamed Elahtem (17431002) Izzaldin Alremawi (17431005) Sabah Akhtar (5809925) Said Dermime (79420) Maysaloun Merhi (4246147) Shahab Uddin (154400) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sourour Idoudi (14153457) Takwa Bedhiafi (14153460) Shona Pedersen (2792278) Mohamed Elahtem (17431002) Izzaldin Alremawi (17431005) Sabah Akhtar (5809925) Said Dermime (79420) Maysaloun Merhi (4246147) Shahab Uddin (154400) |
| dc.date.none.fl_str_mv | 2023-12-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.cellsig.2023.110904 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Role_of_HMGB1_and_its_associated_signaling_pathways_in_human_malignancies/24607332 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences HMGB1 Signaling pathways cancer therapy Immune checkpoint blockade Clinical applications |
| dc.title.none.fl_str_mv | Role of HMGB1 and its associated signaling pathways in human malignancies |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The High-Mobility Group Box-1 (HMGB1), a non-histone chromatin-associated protein, plays a crucial role in cancer growth and response to therapy as it retains a pivotal role in promoting both cell death and survival. HMGB1 has been reported to regulate several signaling pathways engaged in inflammation, genome stability, immune function, cell proliferation, cell autophagy, metabolism, and apoptosis. However, the association between HMGB1 and cancer is complex and its mechanism in tumorigenesis needs to be further elucidated. This review aims to understand the role of HMGB1 in human malignancies and discuss the signaling pathways linked to this process to provide a comprehensive understanding on the association of HMGB1 with carcinogenesis. Further, we will review the role of HMGB1 as a target/biomarker for cancer therapy, the therapeutic strategies used to target this protein, and its potential role in preventing or treating cancers. In light of the recent growing evidence linking HMGB1 to cancer progression, we think that it may be suggested as a novel and emergent therapeutic target for cancer therapy. Hence, HMGB1 warrants paramount investigation to comprehensively map its role in tumorigenesis.</p><h2>Other Information</h2><p dir="ltr">Published in: Cellular Signalling<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cellsig.2023.110904" target="_blank">https://dx.doi.org/10.1016/j.cellsig.2023.110904</a></p><p dir="ltr">Additional institutions affiliated with: Education and Research - HMC, Qatar University Health - QU</p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b241b0adb8f48b3cacfe4fd297d0d580 |
| identifier_str_mv | 10.1016/j.cellsig.2023.110904 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24607332 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Role of HMGB1 and its associated signaling pathways in human malignanciesSourour Idoudi (14153457)Takwa Bedhiafi (14153460)Shona Pedersen (2792278)Mohamed Elahtem (17431002)Izzaldin Alremawi (17431005)Sabah Akhtar (5809925)Said Dermime (79420)Maysaloun Merhi (4246147)Shahab Uddin (154400)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesHMGB1Signaling pathwayscancer therapyImmune checkpoint blockadeClinical applications<p dir="ltr">The High-Mobility Group Box-1 (HMGB1), a non-histone chromatin-associated protein, plays a crucial role in cancer growth and response to therapy as it retains a pivotal role in promoting both cell death and survival. HMGB1 has been reported to regulate several signaling pathways engaged in inflammation, genome stability, immune function, cell proliferation, cell autophagy, metabolism, and apoptosis. However, the association between HMGB1 and cancer is complex and its mechanism in tumorigenesis needs to be further elucidated. This review aims to understand the role of HMGB1 in human malignancies and discuss the signaling pathways linked to this process to provide a comprehensive understanding on the association of HMGB1 with carcinogenesis. Further, we will review the role of HMGB1 as a target/biomarker for cancer therapy, the therapeutic strategies used to target this protein, and its potential role in preventing or treating cancers. In light of the recent growing evidence linking HMGB1 to cancer progression, we think that it may be suggested as a novel and emergent therapeutic target for cancer therapy. Hence, HMGB1 warrants paramount investigation to comprehensively map its role in tumorigenesis.</p><h2>Other Information</h2><p dir="ltr">Published in: Cellular Signalling<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cellsig.2023.110904" target="_blank">https://dx.doi.org/10.1016/j.cellsig.2023.110904</a></p><p dir="ltr">Additional institutions affiliated with: Education and Research - HMC, Qatar University Health - QU</p>2023-12-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.cellsig.2023.110904https://figshare.com/articles/journal_contribution/Role_of_HMGB1_and_its_associated_signaling_pathways_in_human_malignancies/24607332CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/246073322023-12-01T00:00:00Z |
| spellingShingle | Role of HMGB1 and its associated signaling pathways in human malignancies Sourour Idoudi (14153457) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences HMGB1 Signaling pathways cancer therapy Immune checkpoint blockade Clinical applications |
| status_str | publishedVersion |
| title | Role of HMGB1 and its associated signaling pathways in human malignancies |
| title_full | Role of HMGB1 and its associated signaling pathways in human malignancies |
| title_fullStr | Role of HMGB1 and its associated signaling pathways in human malignancies |
| title_full_unstemmed | Role of HMGB1 and its associated signaling pathways in human malignancies |
| title_short | Role of HMGB1 and its associated signaling pathways in human malignancies |
| title_sort | Role of HMGB1 and its associated signaling pathways in human malignancies |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences HMGB1 Signaling pathways cancer therapy Immune checkpoint blockade Clinical applications |