Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach
<h3>Background</h3><p dir="ltr">Salivary (AMY1) and pancreatic (AMY2) amylases hydrolyze starch. Copy number of <i>AMY1A</i> (encoding AMY1) was reported to be higher in populations with a high-starch diet and reduced in obese people. These results based on qu...
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2017
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| _version_ | 1864513556568866816 |
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| author | Amélie Bonnefond (179465) |
| author2 | Loïc Yengo (160556) Aurélie Dechaume (179474) Mickaël Canouil (4117348) Maxime Castelain (19725505) Estelle Roger (19725508) Frédéric Allegaert (19725511) Robert Caiazzo (3165669) Violeta Raverdy (3165681) Marie Pigeyre (3165678) Abdelilah Arredouani (10914455) Jean-Michel Borys (336502) Claire Lévy-Marchal (5653798) Jacques Weill (58255) Ronan Roussel (101806) Beverley Balkau (91114) Michel Marre (91106) François Pattou (145757) Thierry Brousseau (19725514) Philippe Froguel (2247) |
| author2_role | author author author author author author author author author author author author author author author author author author author |
| author_facet | Amélie Bonnefond (179465) Loïc Yengo (160556) Aurélie Dechaume (179474) Mickaël Canouil (4117348) Maxime Castelain (19725505) Estelle Roger (19725508) Frédéric Allegaert (19725511) Robert Caiazzo (3165669) Violeta Raverdy (3165681) Marie Pigeyre (3165678) Abdelilah Arredouani (10914455) Jean-Michel Borys (336502) Claire Lévy-Marchal (5653798) Jacques Weill (58255) Ronan Roussel (101806) Beverley Balkau (91114) Michel Marre (91106) François Pattou (145757) Thierry Brousseau (19725514) Philippe Froguel (2247) |
| author_role | author |
| dc.creator.none.fl_str_mv | Amélie Bonnefond (179465) Loïc Yengo (160556) Aurélie Dechaume (179474) Mickaël Canouil (4117348) Maxime Castelain (19725505) Estelle Roger (19725508) Frédéric Allegaert (19725511) Robert Caiazzo (3165669) Violeta Raverdy (3165681) Marie Pigeyre (3165678) Abdelilah Arredouani (10914455) Jean-Michel Borys (336502) Claire Lévy-Marchal (5653798) Jacques Weill (58255) Ronan Roussel (101806) Beverley Balkau (91114) Michel Marre (91106) François Pattou (145757) Thierry Brousseau (19725514) Philippe Froguel (2247) |
| dc.date.none.fl_str_mv | 2017-02-23T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12916-017-0784-x |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Relationship_between_salivary_pancreatic_amylase_and_body_mass_index_a_systems_biology_approach/27088063 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Nutrition and dietetics AMY1A/AMY2A Body mass index Copy number variant Mendelian randomization Metabonomics Obesity Salivary/Pancreatic amylase Starch |
| dc.title.none.fl_str_mv | Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Salivary (AMY1) and pancreatic (AMY2) amylases hydrolyze starch. Copy number of <i>AMY1A</i> (encoding AMY1) was reported to be higher in populations with a high-starch diet and reduced in obese people. These results based on quantitative PCR have been challenged recently. We aimed to re-assess the relationship between amylase and adiposity using a systems biology approach.</p><h3>Methods</h3><p dir="ltr">We assessed the association between plasma enzymatic activity of AMY1 or AMY2, and several metabolic traits in almost 4000 French individuals from D.E.S.I.R. longitudinal study. The effect of the number of copies of <i>AMY1A</i> (encoding AMY1) or <i>AMY2A</i> (encoding AMY2) measured through droplet digital PCR was then analyzed on the same parameters in the same study. A Mendelian randomization analysis was also performed. We subsequently assessed the association between <i>AMY1A</i> copy number and obesity risk in two case-control studies (5000 samples in total). Finally, we assessed the association between body mass index (BMI)-related plasma metabolites and AMY1 or AMY2 activity.</p><h3>Results</h3><p dir="ltr">We evidenced strong associations between AMY1 or AMY2 activity and lower BMI. However, we found a modest contribution of <i>AMY1A</i> copy number to lower BMI. Mendelian randomization identified a causal negative effect of BMI on AMY1 and AMY2 activities. Yet, we also found a significant negative contribution of AMY1 activity at baseline to the change in BMI during the 9-year follow-up, and a significant contribution of <i>AMY1A</i> copy number to lower obesity risk in children, suggesting a bidirectional relationship between AMY1 activity and adiposity. Metabonomics identified a BMI-independent association between AMY1 activity and lactate, a product of complex carbohydrate fermentation.</p><h3>Conclusions</h3><p dir="ltr">These findings provide new insights into the involvement of amylase in adiposity and starch metabolism.</p><h2>Other Information</h2><p dir="ltr">Published in: BMC Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0/deed.en" rel="noreferrer noopener" target="_blank">https://creativecommons.org/licenses/by/4.0/</a> <br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12916-017-0784-x" target="_blank">https://dx.doi.org/10.1186/s12916-017-0784-x</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b27a2a8941cb77da2ab37cf31f46df15 |
| identifier_str_mv | 10.1186/s12916-017-0784-x |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27088063 |
| publishDate | 2017 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Relationship between salivary/pancreatic amylase and body mass index: a systems biology approachAmélie Bonnefond (179465)Loïc Yengo (160556)Aurélie Dechaume (179474)Mickaël Canouil (4117348)Maxime Castelain (19725505)Estelle Roger (19725508)Frédéric Allegaert (19725511)Robert Caiazzo (3165669)Violeta Raverdy (3165681)Marie Pigeyre (3165678)Abdelilah Arredouani (10914455)Jean-Michel Borys (336502)Claire Lévy-Marchal (5653798)Jacques Weill (58255)Ronan Roussel (101806)Beverley Balkau (91114)Michel Marre (91106)François Pattou (145757)Thierry Brousseau (19725514)Philippe Froguel (2247)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesNutrition and dieteticsAMY1A/AMY2ABody mass indexCopy number variantMendelian randomizationMetabonomicsObesitySalivary/Pancreatic amylaseStarch<h3>Background</h3><p dir="ltr">Salivary (AMY1) and pancreatic (AMY2) amylases hydrolyze starch. Copy number of <i>AMY1A</i> (encoding AMY1) was reported to be higher in populations with a high-starch diet and reduced in obese people. These results based on quantitative PCR have been challenged recently. We aimed to re-assess the relationship between amylase and adiposity using a systems biology approach.</p><h3>Methods</h3><p dir="ltr">We assessed the association between plasma enzymatic activity of AMY1 or AMY2, and several metabolic traits in almost 4000 French individuals from D.E.S.I.R. longitudinal study. The effect of the number of copies of <i>AMY1A</i> (encoding AMY1) or <i>AMY2A</i> (encoding AMY2) measured through droplet digital PCR was then analyzed on the same parameters in the same study. A Mendelian randomization analysis was also performed. We subsequently assessed the association between <i>AMY1A</i> copy number and obesity risk in two case-control studies (5000 samples in total). Finally, we assessed the association between body mass index (BMI)-related plasma metabolites and AMY1 or AMY2 activity.</p><h3>Results</h3><p dir="ltr">We evidenced strong associations between AMY1 or AMY2 activity and lower BMI. However, we found a modest contribution of <i>AMY1A</i> copy number to lower BMI. Mendelian randomization identified a causal negative effect of BMI on AMY1 and AMY2 activities. Yet, we also found a significant negative contribution of AMY1 activity at baseline to the change in BMI during the 9-year follow-up, and a significant contribution of <i>AMY1A</i> copy number to lower obesity risk in children, suggesting a bidirectional relationship between AMY1 activity and adiposity. Metabonomics identified a BMI-independent association between AMY1 activity and lactate, a product of complex carbohydrate fermentation.</p><h3>Conclusions</h3><p dir="ltr">These findings provide new insights into the involvement of amylase in adiposity and starch metabolism.</p><h2>Other Information</h2><p dir="ltr">Published in: BMC Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0/deed.en" rel="noreferrer noopener" target="_blank">https://creativecommons.org/licenses/by/4.0/</a> <br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12916-017-0784-x" target="_blank">https://dx.doi.org/10.1186/s12916-017-0784-x</a></p>2017-02-23T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12916-017-0784-xhttps://figshare.com/articles/journal_contribution/Relationship_between_salivary_pancreatic_amylase_and_body_mass_index_a_systems_biology_approach/27088063CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/270880632017-02-23T06:00:00Z |
| spellingShingle | Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach Amélie Bonnefond (179465) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Nutrition and dietetics AMY1A/AMY2A Body mass index Copy number variant Mendelian randomization Metabonomics Obesity Salivary/Pancreatic amylase Starch |
| status_str | publishedVersion |
| title | Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach |
| title_full | Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach |
| title_fullStr | Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach |
| title_full_unstemmed | Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach |
| title_short | Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach |
| title_sort | Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Nutrition and dietetics AMY1A/AMY2A Body mass index Copy number variant Mendelian randomization Metabonomics Obesity Salivary/Pancreatic amylase Starch |