Poly(lactic-<i>co</i>-glycolic acid) Nanoparticles Loaded with <i>Callistemon citrinus</i> Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell LinesLines
<p>Fruit and vegetable diets rich in phenolic compounds reduce the risk of various cancers and offer multiple other health benefits due to their bioactivity and powerful antioxidant properties. However, the human health benefits of most phenolic compounds are restricted due to their limited aq...
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2019
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| _version_ | 1864513563234664448 |
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| author | Rashid Ahmed (3900679) |
| author2 | Muhammad Tariq (191746) Irfan S. Ahmad (14603327) Hanafy Fouly (14603328) Fakhar-i-Abbas (14603331) MD. Anwarul Hasan (14380156) Mosbah Kushad (14603334) |
| author2_role | author author author author author author |
| author_facet | Rashid Ahmed (3900679) Muhammad Tariq (191746) Irfan S. Ahmad (14603327) Hanafy Fouly (14603328) Fakhar-i-Abbas (14603331) MD. Anwarul Hasan (14380156) Mosbah Kushad (14603334) |
| author_role | author |
| dc.creator.none.fl_str_mv | Rashid Ahmed (3900679) Muhammad Tariq (191746) Irfan S. Ahmad (14603327) Hanafy Fouly (14603328) Fakhar-i-Abbas (14603331) MD. Anwarul Hasan (14380156) Mosbah Kushad (14603334) |
| dc.date.none.fl_str_mv | 2019-07-01T18:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1155/2019/2638481 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Poly_lactic-_i_co_i_-glycolic_acid_Nanoparticles_Loaded_with_i_Callistemon_citrinus_i_Phenolics_Exhibited_Anticancer_Properties_against_Three_Breast_Cancer_Cell_LinesLines/22082807 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Agricultural, veterinary and food sciences Food sciences phenolic compounds health benefits cancer therapeutic drugs |
| dc.title.none.fl_str_mv | Poly(lactic-<i>co</i>-glycolic acid) Nanoparticles Loaded with <i>Callistemon citrinus</i> Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell LinesLines |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Fruit and vegetable diets rich in phenolic compounds reduce the risk of various cancers and offer multiple other health benefits due to their bioactivity and powerful antioxidant properties. However, the human health benefits of most phenolic compounds are restricted due to their limited aqueous solubility, low absorption, restricted passive cellular efflux, and poor gastrointestinal stability. Nanotechnology has been used to deliver various therapeutic drugs to specific targets overcoming many of the limitations of direct treatments. This study was designed to develop poly(lactic-<em>co</em>-glycolic acid) (PLGA) nanoencapsulated phenolic-rich extracts from <em>Callistemon citrinus</em> and berberine and to evaluate their effectiveness against extremely invasive MDA-MB 231, moderately invasive MCF-10A, and minimally invasive MCF-7 breast cancers. We have achieved about 80% encapsulation of phenolics from <em>C. citrinus</em>. Most encapsulated nanoparticles were polygonal with particles sizes of 200 to 250 nm. Release of phenolics from encapsulation during storage was biphasic during the first week and then levelled off thereafter. Nanoencapsulated phenolics from <em>C. citrinus</em> extract, berberine, and combination of both enhanced their bioactivity against the three breast cancer cell lines by nearly 2-fold. Growth inhibition of cells was a linear curve relative to phenolic concentration, with a maximum inhibition of nearly 100% at 0.1 mg/ml compared to control. </p> <h2>Other information</h2> <p>Published in: Journal of Food Quality<br> License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br> See article on publisher's website: <a href="http://dx.doi.org/10.1155/2019/2638481" target="_blank">http://dx.doi.org/10.1155/2019/2638481</a> </p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b3ff5d2c8e607e47a8becbf465d15e61 |
| identifier_str_mv | 10.1155/2019/2638481 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22082807 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Poly(lactic-<i>co</i>-glycolic acid) Nanoparticles Loaded with <i>Callistemon citrinus</i> Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell LinesLinesRashid Ahmed (3900679)Muhammad Tariq (191746)Irfan S. Ahmad (14603327)Hanafy Fouly (14603328)Fakhar-i-Abbas (14603331)MD. Anwarul Hasan (14380156)Mosbah Kushad (14603334)Agricultural, veterinary and food sciencesFood sciencesphenolic compoundshealth benefitscancertherapeutic drugs<p>Fruit and vegetable diets rich in phenolic compounds reduce the risk of various cancers and offer multiple other health benefits due to their bioactivity and powerful antioxidant properties. However, the human health benefits of most phenolic compounds are restricted due to their limited aqueous solubility, low absorption, restricted passive cellular efflux, and poor gastrointestinal stability. Nanotechnology has been used to deliver various therapeutic drugs to specific targets overcoming many of the limitations of direct treatments. This study was designed to develop poly(lactic-<em>co</em>-glycolic acid) (PLGA) nanoencapsulated phenolic-rich extracts from <em>Callistemon citrinus</em> and berberine and to evaluate their effectiveness against extremely invasive MDA-MB 231, moderately invasive MCF-10A, and minimally invasive MCF-7 breast cancers. We have achieved about 80% encapsulation of phenolics from <em>C. citrinus</em>. Most encapsulated nanoparticles were polygonal with particles sizes of 200 to 250 nm. Release of phenolics from encapsulation during storage was biphasic during the first week and then levelled off thereafter. Nanoencapsulated phenolics from <em>C. citrinus</em> extract, berberine, and combination of both enhanced their bioactivity against the three breast cancer cell lines by nearly 2-fold. Growth inhibition of cells was a linear curve relative to phenolic concentration, with a maximum inhibition of nearly 100% at 0.1 mg/ml compared to control. </p> <h2>Other information</h2> <p>Published in: Journal of Food Quality<br> License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br> See article on publisher's website: <a href="http://dx.doi.org/10.1155/2019/2638481" target="_blank">http://dx.doi.org/10.1155/2019/2638481</a> </p>2019-07-01T18:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1155/2019/2638481https://figshare.com/articles/journal_contribution/Poly_lactic-_i_co_i_-glycolic_acid_Nanoparticles_Loaded_with_i_Callistemon_citrinus_i_Phenolics_Exhibited_Anticancer_Properties_against_Three_Breast_Cancer_Cell_LinesLines/22082807CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/220828072019-07-01T18:00:00Z |
| spellingShingle | Poly(lactic-<i>co</i>-glycolic acid) Nanoparticles Loaded with <i>Callistemon citrinus</i> Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell LinesLines Rashid Ahmed (3900679) Agricultural, veterinary and food sciences Food sciences phenolic compounds health benefits cancer therapeutic drugs |
| status_str | publishedVersion |
| title | Poly(lactic-<i>co</i>-glycolic acid) Nanoparticles Loaded with <i>Callistemon citrinus</i> Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell LinesLines |
| title_full | Poly(lactic-<i>co</i>-glycolic acid) Nanoparticles Loaded with <i>Callistemon citrinus</i> Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell LinesLines |
| title_fullStr | Poly(lactic-<i>co</i>-glycolic acid) Nanoparticles Loaded with <i>Callistemon citrinus</i> Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell LinesLines |
| title_full_unstemmed | Poly(lactic-<i>co</i>-glycolic acid) Nanoparticles Loaded with <i>Callistemon citrinus</i> Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell LinesLines |
| title_short | Poly(lactic-<i>co</i>-glycolic acid) Nanoparticles Loaded with <i>Callistemon citrinus</i> Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell LinesLines |
| title_sort | Poly(lactic-<i>co</i>-glycolic acid) Nanoparticles Loaded with <i>Callistemon citrinus</i> Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell LinesLines |
| topic | Agricultural, veterinary and food sciences Food sciences phenolic compounds health benefits cancer therapeutic drugs |