High plasma salivary α-amylase, but not high AMY1 copy number, associated with low obesity rate in Qatari adults: cross-sectional study
<p dir="ltr">The relationship between salivary α-amylase activity (psAAa) or AMY1 copy number and the risk of obesity remains controversial. We aimed to assess this relationship in a cohort from Qatar, where obesity affects 43% of adults. The relationship was investigated cross-secti...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , |
| Published: |
2020
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513512819130368 |
|---|---|
| author | Neyla Al-Akl (12225508) |
| author2 | Richard I. Thompson (2308105) Abdelilah Arredouani (10914455) |
| author2_role | author author |
| author_facet | Neyla Al-Akl (12225508) Richard I. Thompson (2308105) Abdelilah Arredouani (10914455) |
| author_role | author |
| dc.creator.none.fl_str_mv | Neyla Al-Akl (12225508) Richard I. Thompson (2308105) Abdelilah Arredouani (10914455) |
| dc.date.none.fl_str_mv | 2020-10-21T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41598-020-74864-6 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/High_plasma_salivary_-amylase_but_not_high_AMY1_copy_number_associated_with_low_obesity_rate_in_Qatari_adults_cross-sectional_study/25958020 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Nutrition and dietetics Salivary α-amylase activity (psAAa) AMY1 copy number (CN) Obesity Cohort study Whole genome sequencing Adiposity markers High psAAa |
| dc.title.none.fl_str_mv | High plasma salivary α-amylase, but not high AMY1 copy number, associated with low obesity rate in Qatari adults: cross-sectional study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The relationship between salivary α-amylase activity (psAAa) or AMY1 copy number and the risk of obesity remains controversial. We aimed to assess this relationship in a cohort from Qatar, where obesity affects 43% of adults. The relationship was investigated cross-sectionally in 923 Qatari adults from the Qatar biobank cohort. AMY1 CN was estimated form whole genome sequencing data. The associations with obesity prevalence were assessed by linear and logistic regressions. We found no difference in AMY1 CN between obese and normal-weight individuals. However, the psAAa was significantly lower in obese individuals. Significant inverse correlations were found between adiposity markers and psAAa in both sexes, but were marginally stronger in men. A significant effect of high psAAa, but not AMY1 CN, on reduced obesity rates was identified in men (OR per psAAa unit 0.957 [95% CI 0.937–0.977], p < 0.001, with psAAa ranging between 5 to 66 U/L). A significantly higher prevalence of obesity was observed in the lowest quartile of psAAa in men (75% (Q1) vs. 36% (Q4), p < 0.001) and women (74% (Q1) vs 56% (Q4), p = 0.009). Our findings suggest that high psAAa, but not AMY1 CN, has a potential positive benefit against obesity in the Qatari population.</p><h2>Other Information</h2><p dir="ltr">Published in: Scientific Reports<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41598-020-74864-6" target="_blank">https://dx.doi.org/10.1038/s41598-020-74864-6</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b5298b99d7ddfcbafd10a7d188d433e5 |
| identifier_str_mv | 10.1038/s41598-020-74864-6 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25958020 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | High plasma salivary α-amylase, but not high AMY1 copy number, associated with low obesity rate in Qatari adults: cross-sectional studyNeyla Al-Akl (12225508)Richard I. Thompson (2308105)Abdelilah Arredouani (10914455)Biomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicsNutrition and dieteticsSalivary α-amylase activity (psAAa)AMY1 copy number (CN)ObesityCohort studyWhole genome sequencingAdiposity markersHigh psAAa<p dir="ltr">The relationship between salivary α-amylase activity (psAAa) or AMY1 copy number and the risk of obesity remains controversial. We aimed to assess this relationship in a cohort from Qatar, where obesity affects 43% of adults. The relationship was investigated cross-sectionally in 923 Qatari adults from the Qatar biobank cohort. AMY1 CN was estimated form whole genome sequencing data. The associations with obesity prevalence were assessed by linear and logistic regressions. We found no difference in AMY1 CN between obese and normal-weight individuals. However, the psAAa was significantly lower in obese individuals. Significant inverse correlations were found between adiposity markers and psAAa in both sexes, but were marginally stronger in men. A significant effect of high psAAa, but not AMY1 CN, on reduced obesity rates was identified in men (OR per psAAa unit 0.957 [95% CI 0.937–0.977], p < 0.001, with psAAa ranging between 5 to 66 U/L). A significantly higher prevalence of obesity was observed in the lowest quartile of psAAa in men (75% (Q1) vs. 36% (Q4), p < 0.001) and women (74% (Q1) vs 56% (Q4), p = 0.009). Our findings suggest that high psAAa, but not AMY1 CN, has a potential positive benefit against obesity in the Qatari population.</p><h2>Other Information</h2><p dir="ltr">Published in: Scientific Reports<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41598-020-74864-6" target="_blank">https://dx.doi.org/10.1038/s41598-020-74864-6</a></p>2020-10-21T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41598-020-74864-6https://figshare.com/articles/journal_contribution/High_plasma_salivary_-amylase_but_not_high_AMY1_copy_number_associated_with_low_obesity_rate_in_Qatari_adults_cross-sectional_study/25958020CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/259580202020-10-21T09:00:00Z |
| spellingShingle | High plasma salivary α-amylase, but not high AMY1 copy number, associated with low obesity rate in Qatari adults: cross-sectional study Neyla Al-Akl (12225508) Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Nutrition and dietetics Salivary α-amylase activity (psAAa) AMY1 copy number (CN) Obesity Cohort study Whole genome sequencing Adiposity markers High psAAa |
| status_str | publishedVersion |
| title | High plasma salivary α-amylase, but not high AMY1 copy number, associated with low obesity rate in Qatari adults: cross-sectional study |
| title_full | High plasma salivary α-amylase, but not high AMY1 copy number, associated with low obesity rate in Qatari adults: cross-sectional study |
| title_fullStr | High plasma salivary α-amylase, but not high AMY1 copy number, associated with low obesity rate in Qatari adults: cross-sectional study |
| title_full_unstemmed | High plasma salivary α-amylase, but not high AMY1 copy number, associated with low obesity rate in Qatari adults: cross-sectional study |
| title_short | High plasma salivary α-amylase, but not high AMY1 copy number, associated with low obesity rate in Qatari adults: cross-sectional study |
| title_sort | High plasma salivary α-amylase, but not high AMY1 copy number, associated with low obesity rate in Qatari adults: cross-sectional study |
| topic | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Nutrition and dietetics Salivary α-amylase activity (psAAa) AMY1 copy number (CN) Obesity Cohort study Whole genome sequencing Adiposity markers High psAAa |