Did the periodic intensification of routine immunisation strategy (Intensified mission Indradhanush) reduce the demand for pediatric antibiotic formulations in India?
<h3>Background</h3><p dir="ltr">Recent research has indicated an increase in antibiotic utilisation, particularly pediatric formulations. Furthermore, an increasing trend in antimicrobial resistance rates has also been reported. Empirical evidence suggests that immunisati...
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| مؤلفون آخرون: | , , , |
| منشور في: |
2025
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| _version_ | 1864513534716542976 |
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| author | Habib Hasan Farooqui (7861166) |
| author2 | Anup Karan (444710) Aashna Mehta (2136571) Giridhara Rathnaiah Babu (17933762) Onno C. P. van Schayck (7594037) |
| author2_role | author author author author |
| author_facet | Habib Hasan Farooqui (7861166) Anup Karan (444710) Aashna Mehta (2136571) Giridhara Rathnaiah Babu (17933762) Onno C. P. van Schayck (7594037) |
| author_role | author |
| dc.creator.none.fl_str_mv | Habib Hasan Farooqui (7861166) Anup Karan (444710) Aashna Mehta (2136571) Giridhara Rathnaiah Babu (17933762) Onno C. P. van Schayck (7594037) |
| dc.date.none.fl_str_mv | 2025-05-24T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12879-025-11082-3 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Did_the_periodic_intensification_of_routine_immunisation_strategy_Intensified_mission_Indradhanush_reduce_the_demand_for_pediatric_antibiotic_formulations_in_India_/30393256 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Health sciences Epidemiology India Antibiotic utilisation Immunisation Intensified mission Indradhanush Interrupted time series |
| dc.title.none.fl_str_mv | Did the periodic intensification of routine immunisation strategy (Intensified mission Indradhanush) reduce the demand for pediatric antibiotic formulations in India? |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Recent research has indicated an increase in antibiotic utilisation, particularly pediatric formulations. Furthermore, an increasing trend in antimicrobial resistance rates has also been reported. Empirical evidence suggests that immunisation reduces the demand for antibiotics. We examined the potential impact of the periodic intensification of the routine immunisation strategy - Intensified Mission Indradhanush (IMI), which was implemented from October 2017 to January 2018, on antibiotic utilisation in India.</p><h3>Methods</h3><p dir="ltr">We analysed the PharmaTrac dataset to assess the impact of IMI on antibiotic utilisation. We conducted interrupted time series analyses by fitting a Poisson regression model. We used Newey–West standard errors to account for autocorrelation and heteroskedasticity.</p><h3>Findings</h3><p dir="ltr">Poisson segmented regression analysis showed a 12.6% decrease in Fluoroquinolones sales in the first month of IMI implementation (incidence rate ratio [IRR] 0.874, 95%CI: 0.777–0.983). However, post-intervention, their sales remained broadly constant (IRR 1.000, 95%CI 0.995–1.006). Similarly, Chloramphenicol sales decreased by 0.6% in the first month, whereas sales increased by a trend of 0.4% per month (IRR 1.004, 95%CI 0.991–1.017) post-intervention. Interestingly, Trimethoprim sales increased by 17.1% in the first month but decreased by 0.4% per month (IRR 0.959, 95%CI 0.945–0.973) post-intervention. However, there was a modest increase in sales of Macrolides by 3.0%, Cephalosporins by 2.9% and broad-spectrum Penicillin by 0.2% in the first month. Thereafter, Macrolides sales increased by a monthly rate of 0.5% (IRR 1.005, 95% CI 1.000–1.010), Cephalosporins increased by 0.5% (IRR 1.005, 95% CI 1.000 -1.010) and Broad spectrum penicillin increased by 0.9% (IRR 1.009, 95% CI 1.004–1.013) in the post-intervention period. Furthermore, there were heterogeneities across Indian states.</p><h3>Interpretation</h3><p dir="ltr">The IMI’s impact on antibiotic utilisation was heterogeneous across antibiotic classes and Indian states.</p><h2>Other Information</h2><p dir="ltr">Published in: BMC Infectious Diseases<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12879-025-11082-3" target="_blank">https://dx.doi.org/10.1186/s12879-025-11082-3</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b54c176aa8dc997723004b485248b5de |
| identifier_str_mv | 10.1186/s12879-025-11082-3 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30393256 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Did the periodic intensification of routine immunisation strategy (Intensified mission Indradhanush) reduce the demand for pediatric antibiotic formulations in India?Habib Hasan Farooqui (7861166)Anup Karan (444710)Aashna Mehta (2136571)Giridhara Rathnaiah Babu (17933762)Onno C. P. van Schayck (7594037)Biomedical and clinical sciencesPharmacology and pharmaceutical sciencesHealth sciencesEpidemiologyIndiaAntibiotic utilisationImmunisationIntensified missionIndradhanushInterrupted time series<h3>Background</h3><p dir="ltr">Recent research has indicated an increase in antibiotic utilisation, particularly pediatric formulations. Furthermore, an increasing trend in antimicrobial resistance rates has also been reported. Empirical evidence suggests that immunisation reduces the demand for antibiotics. We examined the potential impact of the periodic intensification of the routine immunisation strategy - Intensified Mission Indradhanush (IMI), which was implemented from October 2017 to January 2018, on antibiotic utilisation in India.</p><h3>Methods</h3><p dir="ltr">We analysed the PharmaTrac dataset to assess the impact of IMI on antibiotic utilisation. We conducted interrupted time series analyses by fitting a Poisson regression model. We used Newey–West standard errors to account for autocorrelation and heteroskedasticity.</p><h3>Findings</h3><p dir="ltr">Poisson segmented regression analysis showed a 12.6% decrease in Fluoroquinolones sales in the first month of IMI implementation (incidence rate ratio [IRR] 0.874, 95%CI: 0.777–0.983). However, post-intervention, their sales remained broadly constant (IRR 1.000, 95%CI 0.995–1.006). Similarly, Chloramphenicol sales decreased by 0.6% in the first month, whereas sales increased by a trend of 0.4% per month (IRR 1.004, 95%CI 0.991–1.017) post-intervention. Interestingly, Trimethoprim sales increased by 17.1% in the first month but decreased by 0.4% per month (IRR 0.959, 95%CI 0.945–0.973) post-intervention. However, there was a modest increase in sales of Macrolides by 3.0%, Cephalosporins by 2.9% and broad-spectrum Penicillin by 0.2% in the first month. Thereafter, Macrolides sales increased by a monthly rate of 0.5% (IRR 1.005, 95% CI 1.000–1.010), Cephalosporins increased by 0.5% (IRR 1.005, 95% CI 1.000 -1.010) and Broad spectrum penicillin increased by 0.9% (IRR 1.009, 95% CI 1.004–1.013) in the post-intervention period. Furthermore, there were heterogeneities across Indian states.</p><h3>Interpretation</h3><p dir="ltr">The IMI’s impact on antibiotic utilisation was heterogeneous across antibiotic classes and Indian states.</p><h2>Other Information</h2><p dir="ltr">Published in: BMC Infectious Diseases<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12879-025-11082-3" target="_blank">https://dx.doi.org/10.1186/s12879-025-11082-3</a></p>2025-05-24T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12879-025-11082-3https://figshare.com/articles/journal_contribution/Did_the_periodic_intensification_of_routine_immunisation_strategy_Intensified_mission_Indradhanush_reduce_the_demand_for_pediatric_antibiotic_formulations_in_India_/30393256CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/303932562025-05-24T09:00:00Z |
| spellingShingle | Did the periodic intensification of routine immunisation strategy (Intensified mission Indradhanush) reduce the demand for pediatric antibiotic formulations in India? Habib Hasan Farooqui (7861166) Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Health sciences Epidemiology India Antibiotic utilisation Immunisation Intensified mission Indradhanush Interrupted time series |
| status_str | publishedVersion |
| title | Did the periodic intensification of routine immunisation strategy (Intensified mission Indradhanush) reduce the demand for pediatric antibiotic formulations in India? |
| title_full | Did the periodic intensification of routine immunisation strategy (Intensified mission Indradhanush) reduce the demand for pediatric antibiotic formulations in India? |
| title_fullStr | Did the periodic intensification of routine immunisation strategy (Intensified mission Indradhanush) reduce the demand for pediatric antibiotic formulations in India? |
| title_full_unstemmed | Did the periodic intensification of routine immunisation strategy (Intensified mission Indradhanush) reduce the demand for pediatric antibiotic formulations in India? |
| title_short | Did the periodic intensification of routine immunisation strategy (Intensified mission Indradhanush) reduce the demand for pediatric antibiotic formulations in India? |
| title_sort | Did the periodic intensification of routine immunisation strategy (Intensified mission Indradhanush) reduce the demand for pediatric antibiotic formulations in India? |
| topic | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Health sciences Epidemiology India Antibiotic utilisation Immunisation Intensified mission Indradhanush Interrupted time series |