Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis
<div><h2>Background</h2> <p>Growing evidence suggests a significant association between vitamin D deficiency and RAS. Hence, the present meta-analysis and trial sequential analysis sought to investigate the potential association between low serum vitamin D levels and RAS.<...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2023
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513531026604032 |
|---|---|
| author | Sadeq Ali Al-Maweri (10412616) |
| author2 | Gamilah Al-Qadhi (16415952) Esam Halboub (6302024) Nader Alaizari (16415955) Asma Almeslet (16415958) Kamran Ali (8861576) Safa A. Azim Osman (16415961) |
| author2_role | author author author author author author |
| author_facet | Sadeq Ali Al-Maweri (10412616) Gamilah Al-Qadhi (16415952) Esam Halboub (6302024) Nader Alaizari (16415955) Asma Almeslet (16415958) Kamran Ali (8861576) Safa A. Azim Osman (16415961) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sadeq Ali Al-Maweri (10412616) Gamilah Al-Qadhi (16415952) Esam Halboub (6302024) Nader Alaizari (16415955) Asma Almeslet (16415958) Kamran Ali (8861576) Safa A. Azim Osman (16415961) |
| dc.date.none.fl_str_mv | 2023-06-22T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fnut.2023.1132191 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Vitamin_D_deficiency_and_risk_of_recurrent_aphthous_stomatitis_updated_meta-analysis_with_trial_sequential_analysis/24921525 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Dentistry Nutrition and dietetics Mathematical sciences Statistics aphthous stomatitis vitamin D association risk factor meta-analyses |
| dc.title.none.fl_str_mv | Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><h2>Background</h2> <p>Growing evidence suggests a significant association between vitamin D deficiency and RAS. Hence, the present meta-analysis and trial sequential analysis sought to investigate the potential association between low serum vitamin D levels and RAS.</p> <h2>Methods</h2> <p>PubMed, Scopus, Embase, and Web of Science were comprehensively searched on December 1st, 2022 to retrieve all relevant studies. The grey literature was also searched via ProQuest. All case-control studies on the association between vitamin D and RAS were considered. The quality appraisal of the included studies was done using Newcastle-Ottawa scale. RevMan 5.0 and trial sequential analysis (TSA) programs were used for analyses.</p> <h2>Results</h2> <p>A total of 14 case-control studies with 1468 subjects (721 RAS patients and 747 controls) were included. The pooled data revealed a significant association between low serum levels of vitamin D and the risk of RAS (mean difference = – 8.73, 95% CI: – 12.02 to – 5.44, I2 = 94%, P < 0.00001). Additionally, TSA findings indicated that the current studies surpassed the required information size, confirming that the differences were reliable.</p> <h2>Conclusion</h2> <p>The available evidence suggests that Vitamin D deficiency may have a role in the pathogenesis of RAS. Therefore, evaluation of vitamin D should be considered in RAS patients. Additionally, the results support the possibility of using vitamin D supplements in the management of RAS patients with inadequate serum levels of vitamin D. Future interventional studies are required to evaluate the benefits of vitamin D replacement in prevention and treatment of RAS.</p> </div><h2>Other Information</h2> <p> Published in: Frontiers in Nutrition<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fnut.2023.1132191" target="_blank">https://dx.doi.org/10.3389/fnut.2023.1132191</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b5a75036b9708e7d3ceb361b9c875d36 |
| identifier_str_mv | 10.3389/fnut.2023.1132191 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24921525 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysisSadeq Ali Al-Maweri (10412616)Gamilah Al-Qadhi (16415952)Esam Halboub (6302024)Nader Alaizari (16415955)Asma Almeslet (16415958)Kamran Ali (8861576)Safa A. Azim Osman (16415961)Biomedical and clinical sciencesClinical sciencesDentistryNutrition and dieteticsMathematical sciencesStatisticsaphthous stomatitisvitamin Dassociationrisk factormeta-analyses<div><h2>Background</h2> <p>Growing evidence suggests a significant association between vitamin D deficiency and RAS. Hence, the present meta-analysis and trial sequential analysis sought to investigate the potential association between low serum vitamin D levels and RAS.</p> <h2>Methods</h2> <p>PubMed, Scopus, Embase, and Web of Science were comprehensively searched on December 1st, 2022 to retrieve all relevant studies. The grey literature was also searched via ProQuest. All case-control studies on the association between vitamin D and RAS were considered. The quality appraisal of the included studies was done using Newcastle-Ottawa scale. RevMan 5.0 and trial sequential analysis (TSA) programs were used for analyses.</p> <h2>Results</h2> <p>A total of 14 case-control studies with 1468 subjects (721 RAS patients and 747 controls) were included. The pooled data revealed a significant association between low serum levels of vitamin D and the risk of RAS (mean difference = – 8.73, 95% CI: – 12.02 to – 5.44, I2 = 94%, P < 0.00001). Additionally, TSA findings indicated that the current studies surpassed the required information size, confirming that the differences were reliable.</p> <h2>Conclusion</h2> <p>The available evidence suggests that Vitamin D deficiency may have a role in the pathogenesis of RAS. Therefore, evaluation of vitamin D should be considered in RAS patients. Additionally, the results support the possibility of using vitamin D supplements in the management of RAS patients with inadequate serum levels of vitamin D. Future interventional studies are required to evaluate the benefits of vitamin D replacement in prevention and treatment of RAS.</p> </div><h2>Other Information</h2> <p> Published in: Frontiers in Nutrition<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fnut.2023.1132191" target="_blank">https://dx.doi.org/10.3389/fnut.2023.1132191</a></p>2023-06-22T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fnut.2023.1132191https://figshare.com/articles/journal_contribution/Vitamin_D_deficiency_and_risk_of_recurrent_aphthous_stomatitis_updated_meta-analysis_with_trial_sequential_analysis/24921525CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/249215252023-06-22T03:00:00Z |
| spellingShingle | Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis Sadeq Ali Al-Maweri (10412616) Biomedical and clinical sciences Clinical sciences Dentistry Nutrition and dietetics Mathematical sciences Statistics aphthous stomatitis vitamin D association risk factor meta-analyses |
| status_str | publishedVersion |
| title | Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis |
| title_full | Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis |
| title_fullStr | Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis |
| title_full_unstemmed | Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis |
| title_short | Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis |
| title_sort | Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis |
| topic | Biomedical and clinical sciences Clinical sciences Dentistry Nutrition and dietetics Mathematical sciences Statistics aphthous stomatitis vitamin D association risk factor meta-analyses |