Glucose-6-phosphate dehydrogenase deficiency and neonatal indirect hyperbilirubinemia: a retrospective cohort study among 40,305 consecutively born babies
<h3>Background and objective</h3><p dir="ltr">Glucose-6-phosphate dehydrogenase deficiency (G6PDD) being highly prevalent in the Middle East, the primary objective was to estimate the incidence of neonatal jaundice among G6PD-deficient neonates and to explore its associat...
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2024
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| _version_ | 1864513543708082176 |
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| author | Rajai Rofail Raja Al-Bedaywi (21767666) |
| author2 | Khalil Mohd Khalil Salameh (21767669) Sarfrazul Abedin (14079023) Brijroy Viswanathan (21767672) Abedalkhalik Ahmad Khedr (21767675) Lina Hussain M. Habboub (12405145) |
| author2_role | author author author author author |
| author_facet | Rajai Rofail Raja Al-Bedaywi (21767666) Khalil Mohd Khalil Salameh (21767669) Sarfrazul Abedin (14079023) Brijroy Viswanathan (21767672) Abedalkhalik Ahmad Khedr (21767675) Lina Hussain M. Habboub (12405145) |
| author_role | author |
| dc.creator.none.fl_str_mv | Rajai Rofail Raja Al-Bedaywi (21767666) Khalil Mohd Khalil Salameh (21767669) Sarfrazul Abedin (14079023) Brijroy Viswanathan (21767672) Abedalkhalik Ahmad Khedr (21767675) Lina Hussain M. Habboub (12405145) |
| dc.date.none.fl_str_mv | 2024-03-13T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41372-024-01927-1 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Glucose-6-phosphate_dehydrogenase_deficiency_and_neonatal_indirect_hyperbilirubinemia_a_retrospective_cohort_study_among_40_305_consecutively_born_babies/29625086 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Paediatrics Neonatal jaundice Phototherapy Exchange transfusion Gestational age Birth weight Incidence Risk factors Middle East |
| dc.title.none.fl_str_mv | Glucose-6-phosphate dehydrogenase deficiency and neonatal indirect hyperbilirubinemia: a retrospective cohort study among 40,305 consecutively born babies |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background and objective</h3><p dir="ltr">Glucose-6-phosphate dehydrogenase deficiency (G6PDD) being highly prevalent in the Middle East, the primary objective was to estimate the incidence of neonatal jaundice among G6PD-deficient neonates and to explore its association with various risk factors.</p><h3>Methods</h3><p dir="ltr">This retrospective cohort study includes 7 years data of neonates diagnosed with G6PDD between 1st January 2015, and 30 September 2022, from Al Wakra Hospital, HMC Qatar.</p><h3>Results</h3><p dir="ltr">Among the 40,305 total births, 1013 had G6PDD with an incidence of 2.51%. Of all the G6PDD babies, 24.6% (249/1013) received phototherapy and three babies required exchange transfusion. Statistically significant associations were noted between the need for phototherapy and gestational age, gestational age groups, birth weight, and birth weight groups, but logistic regression analysis showed significant association for phototherapy only with the gestational age group.</p><h3>Conclusion</h3><p dir="ltr">Universal screening and proper follow-up is essential for G6PDD as it plays crucial role in neonatal jaundice.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Perinatology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41372-024-01927-1" target="_blank">https://dx.doi.org/10.1038/s41372-024-01927-1</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b70de70399e3d838dbc893f74d627e62 |
| identifier_str_mv | 10.1038/s41372-024-01927-1 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29625086 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Glucose-6-phosphate dehydrogenase deficiency and neonatal indirect hyperbilirubinemia: a retrospective cohort study among 40,305 consecutively born babiesRajai Rofail Raja Al-Bedaywi (21767666)Khalil Mohd Khalil Salameh (21767669)Sarfrazul Abedin (14079023)Brijroy Viswanathan (21767672)Abedalkhalik Ahmad Khedr (21767675)Lina Hussain M. Habboub (12405145)Biological sciencesGeneticsBiomedical and clinical sciencesPaediatricsNeonatal jaundicePhototherapyExchange transfusionGestational ageBirth weightIncidenceRisk factorsMiddle East<h3>Background and objective</h3><p dir="ltr">Glucose-6-phosphate dehydrogenase deficiency (G6PDD) being highly prevalent in the Middle East, the primary objective was to estimate the incidence of neonatal jaundice among G6PD-deficient neonates and to explore its association with various risk factors.</p><h3>Methods</h3><p dir="ltr">This retrospective cohort study includes 7 years data of neonates diagnosed with G6PDD between 1st January 2015, and 30 September 2022, from Al Wakra Hospital, HMC Qatar.</p><h3>Results</h3><p dir="ltr">Among the 40,305 total births, 1013 had G6PDD with an incidence of 2.51%. Of all the G6PDD babies, 24.6% (249/1013) received phototherapy and three babies required exchange transfusion. Statistically significant associations were noted between the need for phototherapy and gestational age, gestational age groups, birth weight, and birth weight groups, but logistic regression analysis showed significant association for phototherapy only with the gestational age group.</p><h3>Conclusion</h3><p dir="ltr">Universal screening and proper follow-up is essential for G6PDD as it plays crucial role in neonatal jaundice.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Perinatology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41372-024-01927-1" target="_blank">https://dx.doi.org/10.1038/s41372-024-01927-1</a></p>2024-03-13T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41372-024-01927-1https://figshare.com/articles/journal_contribution/Glucose-6-phosphate_dehydrogenase_deficiency_and_neonatal_indirect_hyperbilirubinemia_a_retrospective_cohort_study_among_40_305_consecutively_born_babies/29625086CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/296250862024-03-13T09:00:00Z |
| spellingShingle | Glucose-6-phosphate dehydrogenase deficiency and neonatal indirect hyperbilirubinemia: a retrospective cohort study among 40,305 consecutively born babies Rajai Rofail Raja Al-Bedaywi (21767666) Biological sciences Genetics Biomedical and clinical sciences Paediatrics Neonatal jaundice Phototherapy Exchange transfusion Gestational age Birth weight Incidence Risk factors Middle East |
| status_str | publishedVersion |
| title | Glucose-6-phosphate dehydrogenase deficiency and neonatal indirect hyperbilirubinemia: a retrospective cohort study among 40,305 consecutively born babies |
| title_full | Glucose-6-phosphate dehydrogenase deficiency and neonatal indirect hyperbilirubinemia: a retrospective cohort study among 40,305 consecutively born babies |
| title_fullStr | Glucose-6-phosphate dehydrogenase deficiency and neonatal indirect hyperbilirubinemia: a retrospective cohort study among 40,305 consecutively born babies |
| title_full_unstemmed | Glucose-6-phosphate dehydrogenase deficiency and neonatal indirect hyperbilirubinemia: a retrospective cohort study among 40,305 consecutively born babies |
| title_short | Glucose-6-phosphate dehydrogenase deficiency and neonatal indirect hyperbilirubinemia: a retrospective cohort study among 40,305 consecutively born babies |
| title_sort | Glucose-6-phosphate dehydrogenase deficiency and neonatal indirect hyperbilirubinemia: a retrospective cohort study among 40,305 consecutively born babies |
| topic | Biological sciences Genetics Biomedical and clinical sciences Paediatrics Neonatal jaundice Phototherapy Exchange transfusion Gestational age Birth weight Incidence Risk factors Middle East |