Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar
<h3>Background</h3><p dir="ltr">Some studies have reported that influenza vaccination is associated with lower risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and/or coronavirus disease 2019 (COVID-19) morbidity and mortality. This study aim...
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2023
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| _version_ | 1864513543608467456 |
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| author | Elias Tayar (16488567) |
| author2 | Sami Abdeen (14779537) Muna Abed Alah (14779534) Hiam Chemaitelly (439114) Iheb Bougmiza (8962583) Houssein H. Ayoub (9262512) Anvar Hassan Kaleeckal (11847034) Ali Nizar Latif (11570540) Riyazuddin Mohammad Shaik (11847037) Hamad Eid Al-Romaihi (6837251) Mohamed H. Al-Thani (11847049) Roberto Bertollini (9538620) Laith J. Abu-Raddad (9262524) Abdullatif Al-Khal (11721410) |
| author2_role | author author author author author author author author author author author author author |
| author_facet | Elias Tayar (16488567) Sami Abdeen (14779537) Muna Abed Alah (14779534) Hiam Chemaitelly (439114) Iheb Bougmiza (8962583) Houssein H. Ayoub (9262512) Anvar Hassan Kaleeckal (11847034) Ali Nizar Latif (11570540) Riyazuddin Mohammad Shaik (11847037) Hamad Eid Al-Romaihi (6837251) Mohamed H. Al-Thani (11847049) Roberto Bertollini (9538620) Laith J. Abu-Raddad (9262524) Abdullatif Al-Khal (11721410) |
| author_role | author |
| dc.creator.none.fl_str_mv | Elias Tayar (16488567) Sami Abdeen (14779537) Muna Abed Alah (14779534) Hiam Chemaitelly (439114) Iheb Bougmiza (8962583) Houssein H. Ayoub (9262512) Anvar Hassan Kaleeckal (11847034) Ali Nizar Latif (11570540) Riyazuddin Mohammad Shaik (11847037) Hamad Eid Al-Romaihi (6837251) Mohamed H. Al-Thani (11847049) Roberto Bertollini (9538620) Laith J. Abu-Raddad (9262524) Abdullatif Al-Khal (11721410) |
| dc.date.none.fl_str_mv | 2023-02-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.jiph.2022.12.016 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Effectiveness_of_influenza_vaccination_against_SARS-CoV-2_infection_among_healthcare_workers_in_Qatar/24474655 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Health sciences Public health Influenza COVID-19 Vaccine Case-control Immunity Epidemiology |
| dc.title.none.fl_str_mv | Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Some studies have reported that influenza vaccination is associated with lower risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and/or coronavirus disease 2019 (COVID-19) morbidity and mortality. This study aims to estimate effectiveness of influenza vaccination, using Abbott’s quadrivalent Influvac Tetra vaccine, against SARS-CoV-2 infection and against severe COVID-19.</p><h3>Methods</h3><p dir="ltr">This matched, test-negative, case-control study was implemented on a population of 30,774 healthcare workers (HCWs) in Qatar during the 2020 annual influenza vaccination campaign, September 17, 2020-December 31, 2020, before introduction of COVID-19 vaccination.</p><h3>Results</h3><p dir="ltr">Of 30,774 HCWs, 576 with PCR-positive tests and 10,033 with exclusively PCR-negative tests were eligible for inclusion in the study. Matching by sex, age, nationality, reason for PCR testing, and PCR test date yielded 518 cases matched to 2058 controls. Median duration between influenza vaccination and the PCR test was 43 days (IQR, 29–62). Estimated effectiveness of influenza vaccination against SARS-CoV-2 infection> 14 days after receiving the vaccine was 29.7% (95% CI: 5.5–47.7%). Estimated effectiveness of influenza vaccination against severe, critical, or fatal COVID-19 was 88.9% (95% CI: 4.1–98.7%). Sensitivity analyses confirmed the main analysis results.</p><h3>Conclusions</h3><p dir="ltr">Recent influenza vaccination is associated with a significant reduction in the risk of SARS-CoV-2 infection and COVID-19 severity.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Infection and Public Health<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jiph.2022.12.016" target="_blank">https://dx.doi.org/10.1016/j.jiph.2022.12.016</a></p><p dir="ltr">Additional institutions affiliated with: Ambulance Service - HMC</p><p dir="ltr"><br></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b71fb637e52d9f3a1222273c0577490e |
| identifier_str_mv | 10.1016/j.jiph.2022.12.016 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24474655 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in QatarElias Tayar (16488567)Sami Abdeen (14779537)Muna Abed Alah (14779534)Hiam Chemaitelly (439114)Iheb Bougmiza (8962583)Houssein H. Ayoub (9262512)Anvar Hassan Kaleeckal (11847034)Ali Nizar Latif (11570540)Riyazuddin Mohammad Shaik (11847037)Hamad Eid Al-Romaihi (6837251)Mohamed H. Al-Thani (11847049)Roberto Bertollini (9538620)Laith J. Abu-Raddad (9262524)Abdullatif Al-Khal (11721410)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesHealth sciencesPublic healthInfluenzaCOVID-19VaccineCase-controlImmunityEpidemiology<h3>Background</h3><p dir="ltr">Some studies have reported that influenza vaccination is associated with lower risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and/or coronavirus disease 2019 (COVID-19) morbidity and mortality. This study aims to estimate effectiveness of influenza vaccination, using Abbott’s quadrivalent Influvac Tetra vaccine, against SARS-CoV-2 infection and against severe COVID-19.</p><h3>Methods</h3><p dir="ltr">This matched, test-negative, case-control study was implemented on a population of 30,774 healthcare workers (HCWs) in Qatar during the 2020 annual influenza vaccination campaign, September 17, 2020-December 31, 2020, before introduction of COVID-19 vaccination.</p><h3>Results</h3><p dir="ltr">Of 30,774 HCWs, 576 with PCR-positive tests and 10,033 with exclusively PCR-negative tests were eligible for inclusion in the study. Matching by sex, age, nationality, reason for PCR testing, and PCR test date yielded 518 cases matched to 2058 controls. Median duration between influenza vaccination and the PCR test was 43 days (IQR, 29–62). Estimated effectiveness of influenza vaccination against SARS-CoV-2 infection> 14 days after receiving the vaccine was 29.7% (95% CI: 5.5–47.7%). Estimated effectiveness of influenza vaccination against severe, critical, or fatal COVID-19 was 88.9% (95% CI: 4.1–98.7%). Sensitivity analyses confirmed the main analysis results.</p><h3>Conclusions</h3><p dir="ltr">Recent influenza vaccination is associated with a significant reduction in the risk of SARS-CoV-2 infection and COVID-19 severity.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Infection and Public Health<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jiph.2022.12.016" target="_blank">https://dx.doi.org/10.1016/j.jiph.2022.12.016</a></p><p dir="ltr">Additional institutions affiliated with: Ambulance Service - HMC</p><p dir="ltr"><br></p>2023-02-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.jiph.2022.12.016https://figshare.com/articles/journal_contribution/Effectiveness_of_influenza_vaccination_against_SARS-CoV-2_infection_among_healthcare_workers_in_Qatar/24474655CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/244746552023-02-01T00:00:00Z |
| spellingShingle | Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar Elias Tayar (16488567) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Health sciences Public health Influenza COVID-19 Vaccine Case-control Immunity Epidemiology |
| status_str | publishedVersion |
| title | Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar |
| title_full | Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar |
| title_fullStr | Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar |
| title_full_unstemmed | Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar |
| title_short | Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar |
| title_sort | Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Health sciences Public health Influenza COVID-19 Vaccine Case-control Immunity Epidemiology |