The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis
<h3>Background and Aim</h3><p dir="ltr">Lubiprostone increases chloride and water secretion in the intestines, and several studies have demonstrated the efficacy of lubiprostone in treating functional constipation. Several new clinical trials have emerged since the previo...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2025
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513539425697792 |
|---|---|
| author | Umar Akram (20151411) |
| author2 | Obaid Ur Rehman (6555554) Eeshal Fatima (18255772) Zain Ali Nadeem (20487218) Omer Usman (22282651) Waqas Rasheed (7433984) Ramsha Ali (22282654) Khawaja Abdul Rehman (22282657) Abdulqadir J. Nashwan (11659453) |
| author2_role | author author author author author author author author |
| author_facet | Umar Akram (20151411) Obaid Ur Rehman (6555554) Eeshal Fatima (18255772) Zain Ali Nadeem (20487218) Omer Usman (22282651) Waqas Rasheed (7433984) Ramsha Ali (22282654) Khawaja Abdul Rehman (22282657) Abdulqadir J. Nashwan (11659453) |
| author_role | author |
| dc.creator.none.fl_str_mv | Umar Akram (20151411) Obaid Ur Rehman (6555554) Eeshal Fatima (18255772) Zain Ali Nadeem (20487218) Omer Usman (22282651) Waqas Rasheed (7433984) Ramsha Ali (22282654) Khawaja Abdul Rehman (22282657) Abdulqadir J. Nashwan (11659453) |
| dc.date.none.fl_str_mv | 2025-01-15T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/jgh3.70070 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_Efficacy_of_Lubiprostone_in_Patients_of_Constipation_An_Updated_Systematic_Review_and_Meta_Analysis/30173347 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences chronic idiopathic constipation constipation irritable bowel syndrome lubiprostone opioid induced constipation |
| dc.title.none.fl_str_mv | The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background and Aim</h3><p dir="ltr">Lubiprostone increases chloride and water secretion in the intestines, and several studies have demonstrated the efficacy of lubiprostone in treating functional constipation. Several new clinical trials have emerged since the previous meta‐analysis conducted in 2020. We conducted this updated meta‐analysis to assess clinical efficacy of lubiprostone in these patients.</p><h3>Methods</h3><p dir="ltr">A systematic search was conducted on MEDLINE, Cochrane, and Scopus. Randomized controlled trials published between July 2019 and June 2024 were selected. Cochrane's RoB 2 tool was used to assess the risk of bias. A meta‐analysis was performed and findings were presented using forest plots.</p><h3>Results</h3><p dir="ltr">A total of 14 studies, comprising 4550 patients, were included in the review. Only 12 studies were pooled in the meta‐analysis. Lubiprostone was associated with greater spontaneous bowel movements (SBM) per week (RR 1.454, 95% CI 1.193–1.771) and SBM within 24 h (RR 1.790, 95% CI 1.491–2.150) in patients with chronic idiopathic constipation (CIC). However, it was not associated with abdominal pain in either arm (RR 1.415, 95% CI 0.873–2.294). In opioid‐induced constipation (OIC), lubiprostone increased SBM within 24 h (RR 1.277, 95% CI 1.105–1.475) but did not significantly affect abdominal pain (RR 4.321, 95% CI 0.624–29.941). Lubiprostone improved all selected SBM‐related and abdominal pain outcomes in patients with irritable bowel syndrome with constipation (IBS‐C).</p><h3>Conclusion</h3><p dir="ltr">Lubiprostone significantly improves all SBM‐related outcomes. Owing to its good safety and efficacy profile, lubiprostone can be used in the combination regimens for management of CIC, IBS‐C, and OIC.</p><h2>Other Information</h2><p dir="ltr">Published in: JGH Open<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/jgh3.70070" target="_blank">https://dx.doi.org/10.1002/jgh3.70070</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b725b75dea42a0d397f240ffecd3eb97 |
| identifier_str_mv | 10.1002/jgh3.70070 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30173347 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐AnalysisUmar Akram (20151411)Obaid Ur Rehman (6555554)Eeshal Fatima (18255772)Zain Ali Nadeem (20487218)Omer Usman (22282651)Waqas Rasheed (7433984)Ramsha Ali (22282654)Khawaja Abdul Rehman (22282657)Abdulqadir J. Nashwan (11659453)Biomedical and clinical sciencesClinical sciencesPharmacology and pharmaceutical scienceschronic idiopathic constipationconstipationirritable bowel syndromelubiprostoneopioid induced constipation<h3>Background and Aim</h3><p dir="ltr">Lubiprostone increases chloride and water secretion in the intestines, and several studies have demonstrated the efficacy of lubiprostone in treating functional constipation. Several new clinical trials have emerged since the previous meta‐analysis conducted in 2020. We conducted this updated meta‐analysis to assess clinical efficacy of lubiprostone in these patients.</p><h3>Methods</h3><p dir="ltr">A systematic search was conducted on MEDLINE, Cochrane, and Scopus. Randomized controlled trials published between July 2019 and June 2024 were selected. Cochrane's RoB 2 tool was used to assess the risk of bias. A meta‐analysis was performed and findings were presented using forest plots.</p><h3>Results</h3><p dir="ltr">A total of 14 studies, comprising 4550 patients, were included in the review. Only 12 studies were pooled in the meta‐analysis. Lubiprostone was associated with greater spontaneous bowel movements (SBM) per week (RR 1.454, 95% CI 1.193–1.771) and SBM within 24 h (RR 1.790, 95% CI 1.491–2.150) in patients with chronic idiopathic constipation (CIC). However, it was not associated with abdominal pain in either arm (RR 1.415, 95% CI 0.873–2.294). In opioid‐induced constipation (OIC), lubiprostone increased SBM within 24 h (RR 1.277, 95% CI 1.105–1.475) but did not significantly affect abdominal pain (RR 4.321, 95% CI 0.624–29.941). Lubiprostone improved all selected SBM‐related and abdominal pain outcomes in patients with irritable bowel syndrome with constipation (IBS‐C).</p><h3>Conclusion</h3><p dir="ltr">Lubiprostone significantly improves all SBM‐related outcomes. Owing to its good safety and efficacy profile, lubiprostone can be used in the combination regimens for management of CIC, IBS‐C, and OIC.</p><h2>Other Information</h2><p dir="ltr">Published in: JGH Open<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/jgh3.70070" target="_blank">https://dx.doi.org/10.1002/jgh3.70070</a></p>2025-01-15T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/jgh3.70070https://figshare.com/articles/journal_contribution/The_Efficacy_of_Lubiprostone_in_Patients_of_Constipation_An_Updated_Systematic_Review_and_Meta_Analysis/30173347CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/301733472025-01-15T09:00:00Z |
| spellingShingle | The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis Umar Akram (20151411) Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences chronic idiopathic constipation constipation irritable bowel syndrome lubiprostone opioid induced constipation |
| status_str | publishedVersion |
| title | The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis |
| title_full | The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis |
| title_fullStr | The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis |
| title_full_unstemmed | The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis |
| title_short | The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis |
| title_sort | The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis |
| topic | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences chronic idiopathic constipation constipation irritable bowel syndrome lubiprostone opioid induced constipation |