Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report
<h3>Background</h3><p dir="ltr">Since introducing the SARS-CoV-2 vaccination, different adverse effects and complications have been linked to the vaccine. Variable neurological complications have been reported after receiving the COVID-19 vaccine, such as acute encephalop...
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2021
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| _version_ | 1864513549188988928 |
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| author | Abdulrahman F. Al-Mashdali (17148316) |
| author2 | Yaser M. Ata (14777788) Nagham Sadik (14777557) |
| author2_role | author author |
| author_facet | Abdulrahman F. Al-Mashdali (17148316) Yaser M. Ata (14777788) Nagham Sadik (14777557) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdulrahman F. Al-Mashdali (17148316) Yaser M. Ata (14777788) Nagham Sadik (14777557) |
| dc.date.none.fl_str_mv | 2021-09-03T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.amsu.2021.102803 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Post-COVID-19_vaccine_acute_hyperactive_encephalopathy_with_dramatic_response_to_methylprednisolone_A_case_report/28944302 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Neurosciences COVID-19 Vaccination SARS-CoV-2 Encephalopathy Adverse reaction Case report |
| dc.title.none.fl_str_mv | Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Since introducing the SARS-CoV-2 vaccination, different adverse effects and complications have been linked to the vaccine. Variable neurological complications have been reported after receiving the COVID-19 vaccine, such as acute encephalopathy. </p><h3>Case presentation</h3><p dir="ltr">In this report, we describe a 32-year-old previously healthy man who developed acute confusion, memory disturbances, and auditory hallucination within 24 hours from getting his first dose of the COVID-19 Moderna vaccine.EEG showed features of encephalopathy, CSF investigations were nonspecific, and MRI head did not depict any abnormality. He received five days of ceftriaxone and acyclovir without any benefit. </p><h3>Discussion</h3><p dir="ltr">Extensive workup for different causes of acute encephalopathy, including autoimmune encephalitis, was negative. Also, Our patient improved dramatically after receiving methylprednisolone, supporting an immune-mediated mechanism behind his acute presentation. Accordingly, we think the COVID-19 vaccine is the only possible cause of our patient presentation, giving the temporal relationship and the absence of other risk factors for encephalopathy. </p><h3>Conclusion</h3><p dir="ltr">the clinician should be aware of the possible neurological complications of the different COVID-19 vaccines. Further research is needed to clarify the pathophysiology of such complications.</p><h2>Other Information</h2><p dir="ltr">Published in: Annals of Medicine & Surgery<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.amsu.2021.102803" target="_blank">https://dx.doi.org/10.1016/j.amsu.2021.102803</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b7e8789cc231338d1e671af9d263e65a |
| identifier_str_mv | 10.1016/j.amsu.2021.102803 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/28944302 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case reportAbdulrahman F. Al-Mashdali (17148316)Yaser M. Ata (14777788)Nagham Sadik (14777557)Biomedical and clinical sciencesImmunologyNeurosciencesCOVID-19VaccinationSARS-CoV-2EncephalopathyAdverse reactionCase report<h3>Background</h3><p dir="ltr">Since introducing the SARS-CoV-2 vaccination, different adverse effects and complications have been linked to the vaccine. Variable neurological complications have been reported after receiving the COVID-19 vaccine, such as acute encephalopathy. </p><h3>Case presentation</h3><p dir="ltr">In this report, we describe a 32-year-old previously healthy man who developed acute confusion, memory disturbances, and auditory hallucination within 24 hours from getting his first dose of the COVID-19 Moderna vaccine.EEG showed features of encephalopathy, CSF investigations were nonspecific, and MRI head did not depict any abnormality. He received five days of ceftriaxone and acyclovir without any benefit. </p><h3>Discussion</h3><p dir="ltr">Extensive workup for different causes of acute encephalopathy, including autoimmune encephalitis, was negative. Also, Our patient improved dramatically after receiving methylprednisolone, supporting an immune-mediated mechanism behind his acute presentation. Accordingly, we think the COVID-19 vaccine is the only possible cause of our patient presentation, giving the temporal relationship and the absence of other risk factors for encephalopathy. </p><h3>Conclusion</h3><p dir="ltr">the clinician should be aware of the possible neurological complications of the different COVID-19 vaccines. Further research is needed to clarify the pathophysiology of such complications.</p><h2>Other Information</h2><p dir="ltr">Published in: Annals of Medicine & Surgery<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.amsu.2021.102803" target="_blank">https://dx.doi.org/10.1016/j.amsu.2021.102803</a></p>2021-09-03T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.amsu.2021.102803https://figshare.com/articles/journal_contribution/Post-COVID-19_vaccine_acute_hyperactive_encephalopathy_with_dramatic_response_to_methylprednisolone_A_case_report/28944302CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/289443022021-09-03T03:00:00Z |
| spellingShingle | Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report Abdulrahman F. Al-Mashdali (17148316) Biomedical and clinical sciences Immunology Neurosciences COVID-19 Vaccination SARS-CoV-2 Encephalopathy Adverse reaction Case report |
| status_str | publishedVersion |
| title | Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report |
| title_full | Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report |
| title_fullStr | Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report |
| title_full_unstemmed | Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report |
| title_short | Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report |
| title_sort | Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: A case report |
| topic | Biomedical and clinical sciences Immunology Neurosciences COVID-19 Vaccination SARS-CoV-2 Encephalopathy Adverse reaction Case report |