Comparative efficacy and safety of PD-1/PD-L1 inhibitors in triple negative breast cancer: a systematic review and network meta-analysis of randomized controlled trials

Comparative efficacy and safety of PD-1/PD-L1 inhibitors in triple negative breast cancer: a systematic review and network meta-analysis of randomized controlled trials

<h3>Background</h3><p dir="ltr">Triple-Negative Breast Cancer (TNBC) is a lethal subtype of breast cancer with limited treatment options. The purpose of this Network Meta-Analysis (NMA) is to compare the efficacy and safety of inhibitors of programmed cell death 1 (PD-1)...

Full description

Saved in:

Bibliographic Details
Main Author:	Ibrahim Elmakaty (14614270) (author)
Other Authors:	Ruba Abdo (15455318) (author), Ahmed Elsabagh (15455321) (author), Abdelrahman Elsayed (6288913) (author), Mohammed Imad Malki (9649555) (author)
Published:	2023
Subjects:	Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis PD-1/PD-L1 inhibitors Immune checkpoint inhibitors Overall survival Progression-free survival Pathological complete response Adverse events Efcacy Safety Systematic review Network meta-analysis
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Breast Cancer Cells and PD-1/PD-L1 Blockade Upregulate the Expression of PD-1, CTLA-4, TIM-3 and LAG-3 Immune Checkpoints in CD4+ T Cells
by: Reem Saleh (3513056)
Published: (2019)

Breast Cancer Cells and PD-1/PD-L1 Blockade Upregulate the Expression of PD-1, CTLA-4, TIM-3 and LAG-3 Immune Checkpoints in CD4+ T Cells
by: Reem Saleh (3513056)
Published: (2019)

Serum immune mediators as novel predictors of response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients with high tissue-PD-L1 expression
by: Afsheen Raza (492657)
Published: (2023)

Dasatinib and PD-L1 inhibitors provoke toxicity and inhibit angiogenesis in the embryo
by: Maha, Al-Asmakh
Published: (2020)

Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity
by: Allan Relecom (14153295)
Published: (2021)

Dasatinib and PD-L1 inhibitors provoke toxicity and inhibit angiogenesis in the embryo
by: Maha Al-Asmakh (614593)
Published: (2021)

Immune checkpoint inhibitors: recent progress and potential biomarkers
by: Pramod Darvin (153341)
Published: (2018)

DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer
by: Varun Sasidharan Nair (5396393)
Published: (2018)

DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer
by: Varun Sasidharan Nair (5396393)
Published: (2018)

PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer
by: Reem Saleh (3513056)
Published: (2019)

Editorial: Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer
by: Said Dermime (79420)
Published: (2021)

Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer
by: Said Dermime (79420)
Published: (2021)

Immune Checkpoint Inhibitors in Triple Negative Breast Cancer Treatment: Promising Future Prospects
by: Remy Thomas (702843)
Published: (2021)

Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy
by: Nassiba Taib (14557385)
Published: (2023)

Circulating and Tumor-Infiltrating Immune Checkpoint-Expressing CD8+ Treg/T Cell Subsets and Their Associations with Disease-Free Survival in Colorectal Cancer Patients
by: Alhasan Alsalman (14802873)
Published: (2022)

Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients
by: Shayista Akbar (14442117)
Published: (2023)

Unveiling the effect of shapes and electrolytes on the electrocatalytic ethanol oxidation activity of self-standing Pd nanostructures
by: Adewale K., Ipadeola
Published: (2023)

Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways
by: Hadeel Kheraldine (14231609)
Published: (2024)

Blockade of PD-1, PD-L1, and TIM-3 Altered Distinct Immune- and Cancer-Related Signaling Pathways in the Transcriptome of Human Breast Cancer Explants
by: Reem Saleh (3513056)
Published: (2020)

Unveiling the effect of shapes and electrolytes on the electrocatalytic ethanol oxidation activity of self-standing Pd nanostructures
by: Adewale K. Ipadeola (12699590)
Published: (2023)

Epigenetic regulation of immunosuppressive tumor-associated macrophages through dysregulated microRNAs
by: Aamir Ahmad (233201)
Published: (2022)

CAR-T cell therapy: Efficacy in management of cancers, adverse effects, dose-limiting toxicities and long-term follow up
by: Mohamed Elmarasi (14614276)
Published: (2024)

Unveiling the electrochemical CO oxidation activity on support-free porous PdM (M = Fe, Co, Ni) foam-like nanocrystals over a wide pH range
by: Belal, Salah
Published: (2023)

Safety and efficacy of ensifentrine in COPD: A systemic review and meta-analysis
by: Ambanna Yappalparvi (21260018)
Published: (2024)

Unleashing the immune response to NY-ESO-1 cancer testis antigen as a potential target for cancer immunotherapy
by: Afsheen Raza (492657)
Published: (2022)

The role of PAK4 in the immune system and its potential implication in cancer immunotherapy
by: Azza Naїja (17280610)
Published: (2021)

Unveiling the electrochemical CO oxidation activity on support-free porous PdM (M = Fe, Co, Ni) foam-like nanocrystals over a wide pH range
by: Belal Salah (14150460)
Published: (2023)

Tracheoesophageal fistula and esophageal perforation in a patient with advanced gastroesophageal junction tumor post ramucirumab treatment. A case report and literature review
by: Ahmed Abdalhadi (14152962)
Published: (2023)

Photocatalytic removal of nitrate from water using activated carbon-loaded with bimetallic Pd-Ag nanoparticles under natural solar radiation
by: Ahmed M. Soliman (7406576)
Published: (2022)

Role of HMGB1 and its associated signaling pathways in human malignancies
by: Sourour, Idoudi
Published: (2023)

A community challenge to predict clinical outcomes after immune checkpoint blockade in non-small cell lung cancer
by: Mike Mason (18007491)
Published: (2024)

Effect of Organisational Foresight Capabilities on Business Survival in the UAE Banking Sector – The Mediating Effect of Innovation
by: ALQASEM, MURAD MOHAMMAD
Published: (2024)

Seven novel glucose-6-phosphate dehydrogenase (G6PD) deficiency variants identified in the Qatari population
by: Shaza Malik (18456735)
Published: (2021)

Novel role of BRCA1 interacting C‐terminal helicase 1 (<i>BRIP1</i>) in breast tumour cell invasion
by: Balsam Rizeq (14779402)
Published: (2020)

Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?
by: Abu Saleh Md Moin (6189512)
Published: (2021)

Predicting Remaining Cycle Time from Ongoing Cases: A Survival Analysis-Based Approach
by: Baskharon, Fadi
Published: (2020)

Survival Misperceptions, Time Inconsistency, and Implications for Life-cycle Saving and Welfare
by: Gahramanov, Emin
Published: (2013)

Identification of a Gene Panel Predictive of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy Employing Transcriptomic and Functional Validation
by: Radhakrishnan Vishnubalaji (3563306)
Published: (2022)

FIP1L1- platelet-derived growth factor receptor A -positive chronic eosinophilic leukemia showing dramatic response to imatinib
by: Mohammad Abu-Tineh (14829313)
Published: (2021)

PKD1 is a potential biomarker and therapeutic target in triple-negative breast cancer
by: Caroline Spasojevic (3619418)
Published: (2018)