Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice

Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice

<p dir="ltr">Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. NM1 directly affects mitochondrial oxidative phosphorylation (OXPHOS) by regulating mitochondrial transcription f...

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Main Author: Tomas Venit (17248420) (author)
Other Authors: Oscar Sapkota (19459579) (author), Wael Said Abdrabou (19459582) (author), Palanikumar Loganathan (19459585) (author), Renu Pasricha (2680573) (author), Syed Raza Mahmood (15239737) (author), Nadine Hosny El Said (19459588) (author), Shimaa Sherif (12862990) (author), Sneha Thomas (14424838) (author), Salah Abdelrazig (4054825) (author), Shady Amin (19459591) (author), Davide Bedognetti (2632474) (author), Youssef Idaghdour (44750) (author), Mazin Magzoub (4583662) (author), Piergiorgio Percipalle (393101) (author)
Published: 2023
Subjects:
Biomedical and clinical sciences
Clinical sciences
Medical biochemistry and metabolomics
Oncology and carcinogenesis
Metabolic Reprogramming
Tumorigenesis
Nuclear Myosin 1 (NM1)
Cellular Metabolism
Aerobic Glycolysis
Warburg Effect
Cancer Metabolism
Metabolomics
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