Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigm
<p dir="ltr">Colorectal cancer (CRC) is a significant global health challenge, ranking as the third most common cancer and the second leading cause of cancer-related deaths worldwide. Its development is influenced by several risk factors, including smoking, diets rich in red meat, an...
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2025
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513524557938688 |
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| author | Aya Ghosn (22997230) |
| author2 | Khalil Bassam (9262438) Mohammad Al Zein (20090700) Suzanne A. Nasser (17563161) Gianfranco Pintus (91638) Ali H. Eid (5461829) |
| author2_role | author author author author author |
| author_facet | Aya Ghosn (22997230) Khalil Bassam (9262438) Mohammad Al Zein (20090700) Suzanne A. Nasser (17563161) Gianfranco Pintus (91638) Ali H. Eid (5461829) |
| author_role | author |
| dc.creator.none.fl_str_mv | Aya Ghosn (22997230) Khalil Bassam (9262438) Mohammad Al Zein (20090700) Suzanne A. Nasser (17563161) Gianfranco Pintus (91638) Ali H. Eid (5461829) |
| dc.date.none.fl_str_mv | 2025-09-15T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s10787-025-01925-5 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Pharmacological_interventions_targeting_-adrenoceptors_in_colorectal_cancer_an_evolving_paradigm/31056565 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Malignancy Chemotherapy VEGF COX-2 Cyclin microRNA Adrenergic |
| dc.title.none.fl_str_mv | Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigm |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Colorectal cancer (CRC) is a significant global health challenge, ranking as the third most common cancer and the second leading cause of cancer-related deaths worldwide. Its development is influenced by several risk factors, including smoking, diets rich in red meat, and the effects of stress-related hormones such as epinephrine and norepinephrine. These hormones act through β-adrenergic receptors (β-ARs), which are present on CRC cells and are associated with cancer-promoting processes such as increased cell growth, invasion, blood vessel formation, and accelerated disease progression. Notably, β-ARs blockers have shown potential in slowing CRC progression, pointing to a promising therapeutic strategy. This review explores the main signaling pathways through which β-ARs contribute to cancer development and how various risk factors may influence these mechanisms. We also provide an overview of current preclinical and clinical studies on β-AR blockers in CRC, identify existing gaps in knowledge, and propose directions for future research to optimize therapeutic outcomes.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Inflammopharmacology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s10787-025-01925-5" target="_blank">https://dx.doi.org/10.1007/s10787-025-01925-5</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b8d3792a13b3ca7042bd3fc6e46bd918 |
| identifier_str_mv | 10.1007/s10787-025-01925-5 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/31056565 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigmAya Ghosn (22997230)Khalil Bassam (9262438)Mohammad Al Zein (20090700)Suzanne A. Nasser (17563161)Gianfranco Pintus (91638)Ali H. Eid (5461829)Biomedical and clinical sciencesMedical biochemistry and metabolomicsOncology and carcinogenesisPharmacology and pharmaceutical sciencesMalignancyChemotherapyVEGFCOX-2 CyclinmicroRNAAdrenergic<p dir="ltr">Colorectal cancer (CRC) is a significant global health challenge, ranking as the third most common cancer and the second leading cause of cancer-related deaths worldwide. Its development is influenced by several risk factors, including smoking, diets rich in red meat, and the effects of stress-related hormones such as epinephrine and norepinephrine. These hormones act through β-adrenergic receptors (β-ARs), which are present on CRC cells and are associated with cancer-promoting processes such as increased cell growth, invasion, blood vessel formation, and accelerated disease progression. Notably, β-ARs blockers have shown potential in slowing CRC progression, pointing to a promising therapeutic strategy. This review explores the main signaling pathways through which β-ARs contribute to cancer development and how various risk factors may influence these mechanisms. We also provide an overview of current preclinical and clinical studies on β-AR blockers in CRC, identify existing gaps in knowledge, and propose directions for future research to optimize therapeutic outcomes.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Inflammopharmacology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s10787-025-01925-5" target="_blank">https://dx.doi.org/10.1007/s10787-025-01925-5</a></p>2025-09-15T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s10787-025-01925-5https://figshare.com/articles/journal_contribution/Pharmacological_interventions_targeting_-adrenoceptors_in_colorectal_cancer_an_evolving_paradigm/31056565CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/310565652025-09-15T09:00:00Z |
| spellingShingle | Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigm Aya Ghosn (22997230) Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Malignancy Chemotherapy VEGF COX-2 Cyclin microRNA Adrenergic |
| status_str | publishedVersion |
| title | Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigm |
| title_full | Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigm |
| title_fullStr | Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigm |
| title_full_unstemmed | Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigm |
| title_short | Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigm |
| title_sort | Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigm |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Malignancy Chemotherapy VEGF COX-2 Cyclin microRNA Adrenergic |