Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications
<p>The immune system has a substantial effect on colorectal cancer (CRC) progression. Additionally, the response to immunotherapeutics and conventional treatment options (e.g., chemotherapy, radiotherapy and targeted therapies) is influenced by the immune system. The molecular characterization...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2017
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513510845710336 |
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| author | Jessica Roelands (7516439) |
| author2 | Peter Kuppen (3853129) Louis Vermeulen (222304) Cristina Maccalli (2632465) Julie Decock (44558) Ena Wang (802) Francesco Marincola (3441314) Davide Bedognetti (2632474) Wouter Hendrickx (44559) |
| author2_role | author author author author author author author author |
| author_facet | Jessica Roelands (7516439) Peter Kuppen (3853129) Louis Vermeulen (222304) Cristina Maccalli (2632465) Julie Decock (44558) Ena Wang (802) Francesco Marincola (3441314) Davide Bedognetti (2632474) Wouter Hendrickx (44559) |
| author_role | author |
| dc.creator.none.fl_str_mv | Jessica Roelands (7516439) Peter Kuppen (3853129) Louis Vermeulen (222304) Cristina Maccalli (2632465) Julie Decock (44558) Ena Wang (802) Francesco Marincola (3441314) Davide Bedognetti (2632474) Wouter Hendrickx (44559) |
| dc.date.none.fl_str_mv | 2017-10-24T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/ijms18102229 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Immunogenomic_Classification_of_Colorectal_Cancer_and_Therapeutic_Implications/26018878 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Oncology and carcinogenesis colorectal cancer tumor microenvironment immune contexture immunologic constant of rejection consensus molecular subtypes immunotherapy combination therapy |
| dc.title.none.fl_str_mv | Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>The immune system has a substantial effect on colorectal cancer (CRC) progression. Additionally, the response to immunotherapeutics and conventional treatment options (e.g., chemotherapy, radiotherapy and targeted therapies) is influenced by the immune system. The molecular characterization of colorectal cancer (CRC) has led to the identification of favorable and unfavorable immunological attributes linked to clinical outcome. With the definition of consensus molecular subtypes (CMSs) based on transcriptomic profiles, multiple characteristics have been proposed to be responsible for the development of the tumor immune microenvironment and corresponding mechanisms of immune escape. In this review, a detailed description of proposed immune phenotypes as well as their interaction with different therapeutic modalities will be provided. Finally, possible strategies to shift the CRC immune phenotype towards a reactive, anti-tumor orientation are proposed per CMS.</p><h2>Other Information</h2> <p> Published in: International Journal of Molecular Sciences<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms18102229" target="_blank">https://dx.doi.org/10.3390/ijms18102229</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b8d41eb2370de3163099b14153d627ce |
| identifier_str_mv | 10.3390/ijms18102229 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26018878 |
| publishDate | 2017 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Immunogenomic Classification of Colorectal Cancer and Therapeutic ImplicationsJessica Roelands (7516439)Peter Kuppen (3853129)Louis Vermeulen (222304)Cristina Maccalli (2632465)Julie Decock (44558)Ena Wang (802)Francesco Marincola (3441314)Davide Bedognetti (2632474)Wouter Hendrickx (44559)Biomedical and clinical sciencesImmunologyOncology and carcinogenesiscolorectal cancertumor microenvironmentimmune contextureimmunologic constant of rejectionconsensus molecular subtypesimmunotherapycombination therapy<p>The immune system has a substantial effect on colorectal cancer (CRC) progression. Additionally, the response to immunotherapeutics and conventional treatment options (e.g., chemotherapy, radiotherapy and targeted therapies) is influenced by the immune system. The molecular characterization of colorectal cancer (CRC) has led to the identification of favorable and unfavorable immunological attributes linked to clinical outcome. With the definition of consensus molecular subtypes (CMSs) based on transcriptomic profiles, multiple characteristics have been proposed to be responsible for the development of the tumor immune microenvironment and corresponding mechanisms of immune escape. In this review, a detailed description of proposed immune phenotypes as well as their interaction with different therapeutic modalities will be provided. Finally, possible strategies to shift the CRC immune phenotype towards a reactive, anti-tumor orientation are proposed per CMS.</p><h2>Other Information</h2> <p> Published in: International Journal of Molecular Sciences<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms18102229" target="_blank">https://dx.doi.org/10.3390/ijms18102229</a></p>2017-10-24T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/ijms18102229https://figshare.com/articles/journal_contribution/Immunogenomic_Classification_of_Colorectal_Cancer_and_Therapeutic_Implications/26018878CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/260188782017-10-24T06:00:00Z |
| spellingShingle | Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications Jessica Roelands (7516439) Biomedical and clinical sciences Immunology Oncology and carcinogenesis colorectal cancer tumor microenvironment immune contexture immunologic constant of rejection consensus molecular subtypes immunotherapy combination therapy |
| status_str | publishedVersion |
| title | Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications |
| title_full | Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications |
| title_fullStr | Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications |
| title_full_unstemmed | Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications |
| title_short | Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications |
| title_sort | Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications |
| topic | Biomedical and clinical sciences Immunology Oncology and carcinogenesis colorectal cancer tumor microenvironment immune contexture immunologic constant of rejection consensus molecular subtypes immunotherapy combination therapy |