Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications

Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications

<p>The immune system has a substantial effect on colorectal cancer (CRC) progression. Additionally, the response to immunotherapeutics and conventional treatment options (e.g., chemotherapy, radiotherapy and targeted therapies) is influenced by the immune system. The molecular characterization...

Full description

Saved in:

Bibliographic Details
Main Author:	Jessica Roelands (7516439) (author)
Other Authors:	Peter Kuppen (3853129) (author), Louis Vermeulen (222304) (author), Cristina Maccalli (2632465) (author), Julie Decock (44558) (author), Ena Wang (802) (author), Francesco Marincola (3441314) (author), Davide Bedognetti (2632474) (author), Wouter Hendrickx (44559) (author)
Published:	2017
Subjects:	Biomedical and clinical sciences Immunology Oncology and carcinogenesis colorectal cancer tumor microenvironment immune contexture immunologic constant of rejection consensus molecular subtypes immunotherapy combination therapy
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification
by: Jessica Roelands (7516439)
Published: (2018)

Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients
by: Salman M. Toor (8854751)
Published: (2019)

Location matters: spatial dynamics of tumor-infiltrating T cell subsets is prognostic in colon cancer
by: Hehuan Zhu (4808445)
Published: (2024)

Comparison of Myeloid Cells in Circulation and in the Tumor Microenvironment of Patients with Colorectal and Breast Cancers
by: Salman M. Toor (8854751)
Published: (2017)

Transcriptome of Tumor-Infiltrating T Cells in Colorectal Cancer Patients Uncovered a Unique Gene Signature in CD4+ T Cells Associated with Poor Disease-Specific Survival
by: Salman M. Toor (8854751)
Published: (2021)

Intratumoral FoxP3<sup>+</sup>Helios<sup>+</sup> Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer
by: Azharuddin Sajid Syed Khaja (19720114)
Published: (2017)

Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients
by: Salman M. Toor (8854751)
Published: (2016)

Unveiling the nexus: The tumor microenvironment as a strategic frontier in viral cancers
by: Fernandes, Queenie
Published: (2025)

The Cross Talk between Cancer Stem Cells/Cancer Initiating Cells and Tumor Microenvironment: The Missing Piece of the Puzzle for the Efficient Targeting of these Cells with Immunotherapy
by: Shilpa Ravindran (3627299)
Published: (2019)

Network-based identification of key master regulators associated with an immune-silent cancer phenotype
by: Raghvendra Mall (581171)
Published: (2021)

Exosomes: Biological Carriers and Promising Tools for Cancer Immunotherapy
by: Reem Saleh (3513056)
Published: (2020)

Transcriptomic Profiling of Tumor-Infiltrating CD4<sup>+</sup>TIM-3<sup>+</sup> T Cells Reveals Their Suppressive, Exhausted, and Metastatic Characteristics in Colorectal Cancer Patients
by: Varun Sasidharan Nair (5396393)
Published: (2020)

B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention
by: Elizabeth Varghese (11008845)
Published: (2023)

Unleashing the immune response to NY-ESO-1 cancer testis antigen as a potential target for cancer immunotherapy
by: Afsheen Raza (492657)
Published: (2022)

Cytokine‐ and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy
by: Ajaz A. Bhat (12984701)
Published: (2022)

Correlation of Immunological and Histopathological Features with Gene Expression-Based Classifiers in Colon Cancer Patients
by: Simone van de Weerd (18282199)
Published: (2022)

Unveiling the nexus: The tumor microenvironment as a strategic frontier in viral cancers
by: Queenie Fernandes (14557388)
Published: (2024)

Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting
by: Belal Chaudhary (19738021)
Published: (2016)

CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances
by: Karama Makni Maalej (17821424)
Published: (2023)

The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms
by: Farah Karam (22330564)
Published: (2025)

Role of circular RNAs in colorectal tumor microenvironment
by: Jasni Viralippurath Ashraf (16931820)
Published: (2021)

Expression of immune checkpoints and T cell exhaustion markers in early and advanced stages of colorectal cancer
by: Reem Saleh (3513056)
Published: (2020)

The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer
by: Kodappully S. Siveen (4246150)
Published: (2019)

Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy
by: Ajaz A. Bhat (12984701)
Published: (2021)

Lactate Metabolism and Immune Modulation in Breast Cancer: A Focused Review on Triple Negative Breast Tumors
by: Adviti Naik (673163)
Published: (2020)

Editorial: Tumor microenvironment, inflammation, and resistance to immunotherapies
by: Julie Decock (44558)
Published: (2023)

The Obesity Paradox in Cancer, Tumor Immunology, and Immunotherapy: Potential Therapeutic Implications in Triple Negative Breast Cancer
by: Adviti Naik (673163)
Published: (2019)

DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer
by: Varun Sasidharan Nair (5396393)
Published: (2018)

The role of PAK4 in the immune system and its potential implication in cancer immunotherapy
by: Azza Naїja (17280610)
Published: (2021)

Transcriptomic Analyses Revealed Systemic Alterations in Gene Expression in Circulation and Tumor Microenvironment of Colorectal Cancer Patients
by: Hibah Shaath (5599658)
Published: (2019)

Myeloid cells in circulation and tumor microenvironment of breast cancer patients
by: Salman M. Toor (8854751)
Published: (2017)

RNA-Seq Analysis of Colorectal Tumor-Infiltrating Myeloid-Derived Suppressor Cell Subsets Revealed Gene Signatures of Poor Prognosis
by: Reem Saleh (3513056)
Published: (2020)

Immune Checkpoint Inhibitors in Triple Negative Breast Cancer Treatment: Promising Future Prospects
by: Remy Thomas (702843)
Published: (2021)

Comparative analysis of within-host diversity among vaccinated COVID-19 patients infected with different SARS-CoV-2 variants
by: Hebah A., Al-Khatib
Published: (2022)

Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief Review
by: Queenie Fernandes (14557388)
Published: (2020)

Exosome nanovesicles as potential biomarkers and immune checkpoint signaling modulators in lung cancer microenvironment: recent advances and emerging concepts
by: Naushad Ahmad Khan (6406973)
Published: (2023)

Transcriptomic Analyses of Myeloid-Derived Suppressor Cell Subsets in the Circulation of Colorectal Cancer Patients
by: Varun Sasidharan Nair (5396393)
Published: (2020)

The multiomics analyses of cancer stem cells isolated from solid tumors can provide insight for their immunological characterization.
by: Neha Gopinath (15431052)
Published: (2023)

Immune checkpoint inhibitors: recent progress and potential biomarkers
by: Pramod Darvin (153341)
Published: (2018)

Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer
by: Afsheen Raza (492657)
Published: (2022)