The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies
<h2>Background</h2> <p>Critical appraisal aids in assessing the quality of scientific literature, which is central to the practice of evidence-based medicine. Several tools and guidelines are available for critiquing and assessing the quality of specific study types. However, limit...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , |
| منشور في: |
2022
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513567529631744 |
|---|---|
| author | Alaa Bahaa Eldeen Soliman (14151519) |
| author2 | Shane Ashley Pawluk (11014418) Kyle John Wilby (14151486) Ousama Rachid (14158917) |
| author2_role | author author author |
| author_facet | Alaa Bahaa Eldeen Soliman (14151519) Shane Ashley Pawluk (11014418) Kyle John Wilby (14151486) Ousama Rachid (14158917) |
| author_role | author |
| dc.creator.none.fl_str_mv | Alaa Bahaa Eldeen Soliman (14151519) Shane Ashley Pawluk (11014418) Kyle John Wilby (14151486) Ousama Rachid (14158917) |
| dc.date.none.fl_str_mv | 2022-11-22T21:14:11Z |
| dc.identifier.none.fl_str_mv | 10.1007/s11096-022-01390-y |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_use_of_a_modified_Delphi_technique_to_develop_a_critical_appraisal_tool_for_clinical_pharmacokinetic_studies/21597468 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Pharmacology and pharmaceutical sciences Pharmacology (medical) Pharmaceutical Science Pharmacology Toxicology Pharmacy |
| dc.title.none.fl_str_mv | The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h2>Background</h2> <p>Critical appraisal aids in assessing the quality of scientific literature, which is central to the practice of evidence-based medicine. Several tools and guidelines are available for critiquing and assessing the quality of specific study types. However, limited guidance exists for critical appraisal of clinical pharmacokinetic studies.</p> <h2>Aim</h2> <p>We aimed to achieve experts’ consensus regarding the quality markers for clinical pharmacokinetic studies in an attempt to develop a critical appraisal tool.</p> <h2>Method</h2> <p>Quality markers related to clinical pharmacokinetic studies, were derived from the published literature and categorized according to manuscript reporting domains (abstract, introduction/background, methodology, results, discussion, and conclusion). Questions that aid in appraising pharmacokinetic studies were formulated from these quality markers. Experts were involved in a modified Delphi process to achieve a consensus regarding the formulated questions. The proposed tool was pilot tested on 30 recently published clinical pharmacokinetic studies. Inter-observer agreement was measured to determine the reliability of the included items.</p> <h2>Results</h2> <p>Twenty-five experts consented to participate. Three rounds of a modified Delphi survey were required to generate a consensus for a 21-item tool aimed at appraising the quality of clinical pharmacokinetic studies. When applied to 30 recently published clinical pharmacokinetic studies, most items scored fair to moderate levels of agreement (61.90–95.24%).</p> <h2>Conclusion</h2> <p>The clinical pharmacokinetic critical appraisal tool (CACPK) developed in this study consisted of 21 items aimed at helping an end-user to determine the quality of a pharmacokinetic study. Further studies are warranted to reaffirm the validity and reliability of the CACPK tool.</p><h2>Other Information</h2> <p> Published in: International Journal of Clinical Pharmacy<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s11096-022-01390-y" target="_blank">http://dx.doi.org/10.1007/s11096-022-01390-y</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b8f600d10e678e83b73a8138f0167bee |
| identifier_str_mv | 10.1007/s11096-022-01390-y |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21597468 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studiesAlaa Bahaa Eldeen Soliman (14151519)Shane Ashley Pawluk (11014418)Kyle John Wilby (14151486)Ousama Rachid (14158917)Pharmacology and pharmaceutical sciencesPharmacology (medical)Pharmaceutical SciencePharmacologyToxicologyPharmacy<h2>Background</h2> <p>Critical appraisal aids in assessing the quality of scientific literature, which is central to the practice of evidence-based medicine. Several tools and guidelines are available for critiquing and assessing the quality of specific study types. However, limited guidance exists for critical appraisal of clinical pharmacokinetic studies.</p> <h2>Aim</h2> <p>We aimed to achieve experts’ consensus regarding the quality markers for clinical pharmacokinetic studies in an attempt to develop a critical appraisal tool.</p> <h2>Method</h2> <p>Quality markers related to clinical pharmacokinetic studies, were derived from the published literature and categorized according to manuscript reporting domains (abstract, introduction/background, methodology, results, discussion, and conclusion). Questions that aid in appraising pharmacokinetic studies were formulated from these quality markers. Experts were involved in a modified Delphi process to achieve a consensus regarding the formulated questions. The proposed tool was pilot tested on 30 recently published clinical pharmacokinetic studies. Inter-observer agreement was measured to determine the reliability of the included items.</p> <h2>Results</h2> <p>Twenty-five experts consented to participate. Three rounds of a modified Delphi survey were required to generate a consensus for a 21-item tool aimed at appraising the quality of clinical pharmacokinetic studies. When applied to 30 recently published clinical pharmacokinetic studies, most items scored fair to moderate levels of agreement (61.90–95.24%).</p> <h2>Conclusion</h2> <p>The clinical pharmacokinetic critical appraisal tool (CACPK) developed in this study consisted of 21 items aimed at helping an end-user to determine the quality of a pharmacokinetic study. Further studies are warranted to reaffirm the validity and reliability of the CACPK tool.</p><h2>Other Information</h2> <p> Published in: International Journal of Clinical Pharmacy<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s11096-022-01390-y" target="_blank">http://dx.doi.org/10.1007/s11096-022-01390-y</a></p>2022-11-22T21:14:11ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s11096-022-01390-yhttps://figshare.com/articles/journal_contribution/The_use_of_a_modified_Delphi_technique_to_develop_a_critical_appraisal_tool_for_clinical_pharmacokinetic_studies/21597468CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215974682022-11-22T21:14:11Z |
| spellingShingle | The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies Alaa Bahaa Eldeen Soliman (14151519) Pharmacology and pharmaceutical sciences Pharmacology (medical) Pharmaceutical Science Pharmacology Toxicology Pharmacy |
| status_str | publishedVersion |
| title | The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies |
| title_full | The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies |
| title_fullStr | The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies |
| title_full_unstemmed | The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies |
| title_short | The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies |
| title_sort | The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies |
| topic | Pharmacology and pharmaceutical sciences Pharmacology (medical) Pharmaceutical Science Pharmacology Toxicology Pharmacy |