Inhomogeneity of lung ventilation in children with obesity and its potential role in worsening asthma
<p dir="ltr">Asthma is more frequent and severe in individuals with obesity compared to those with normal weight. While inhomogeneity of lung ventilation due to distal airway obstruction is a key feature in asthma, the effect of obesity on ventilation homogeneity is unclear. We condu...
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2025
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| _version_ | 1864513534556110848 |
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| author | Ahmed Abushahin (17337703) |
| author2 | Mutasim Abu‐Hasan (22466755) Harshita Shailesh (14779408) Belavendra Antonisamy (216616) Yahya Hani (3095103) Abidan Muhayimana (22466758) Majed Al Theyab (22466761) Ibrahim Janahi (3744933) |
| author2_role | author author author author author author author |
| author_facet | Ahmed Abushahin (17337703) Mutasim Abu‐Hasan (22466755) Harshita Shailesh (14779408) Belavendra Antonisamy (216616) Yahya Hani (3095103) Abidan Muhayimana (22466758) Majed Al Theyab (22466761) Ibrahim Janahi (3744933) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ahmed Abushahin (17337703) Mutasim Abu‐Hasan (22466755) Harshita Shailesh (14779408) Belavendra Antonisamy (216616) Yahya Hani (3095103) Abidan Muhayimana (22466758) Majed Al Theyab (22466761) Ibrahim Janahi (3744933) |
| dc.date.none.fl_str_mv | 2025-04-17T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.14814/phy2.70257 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Inhomogeneity_of_lung_ventilation_in_children_with_obesity_and_its_potential_role_in_worsening_asthma/30405622 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Paediatrics asthma children lung clearance index lung function obesity ventilation inhomogeneity |
| dc.title.none.fl_str_mv | Inhomogeneity of lung ventilation in children with obesity and its potential role in worsening asthma |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Asthma is more frequent and severe in individuals with obesity compared to those with normal weight. While inhomogeneity of lung ventilation due to distal airway obstruction is a key feature in asthma, the effect of obesity on ventilation homogeneity is unclear. We conducted a cross‐sectional study comparing lung clearance index (LCI) using multiple breath nitrogen washout technique between children with normal weight and asthma (<i>n</i> = 97), overweight/obesity and asthma (<i>n</i> = 100), overweight/obesity and no asthma (<i>n</i> = 100), and children with normal weight and no asthma (<i>n</i> = 67). Spirometry, lung volumes, and fractional exhaled nitric oxide (FeNO) were obtained for comparison. Results showed no significant difference in LCI between overweight/obesity groups and normal weight groups and no significant correlation between LCI and body mass index (BMI). However, LCI was higher in the asthma groups compared to non‐asthma groups (<i>p</i> = 0.017, <i>p</i> = 0.003). There was a significant negative correlation between LCI and FEV1% predicted, FEV1/FVC, and FEF25–75% predicted (<i>r </i>= −0.24, <i>p</i> < 0.001; <i>r </i>= −0.26, p< 0.001; r = −0.23, <i>p</i> < 0.001), and a positive correlation with RV/TLC (<i>r</i> = 0.17, p = 0.003) and FeNO (<i>r</i> = 0.29, <i>p</i>< 0.001). These findings indicate that obesity does not affect the homogeneity of lung ventilation. Therefore, alternative mechanisms should be considered to explain the association between asthma and obesity.</p><h2>Other Information</h2><p dir="ltr">Published in: Physiological Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.14814/phy2.70257" target="_blank">https://dx.doi.org/10.14814/phy2.70257</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b92139d94e8907e2b904d05b7ca491ae |
| identifier_str_mv | 10.14814/phy2.70257 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30405622 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Inhomogeneity of lung ventilation in children with obesity and its potential role in worsening asthmaAhmed Abushahin (17337703)Mutasim Abu‐Hasan (22466755)Harshita Shailesh (14779408)Belavendra Antonisamy (216616)Yahya Hani (3095103)Abidan Muhayimana (22466758)Majed Al Theyab (22466761)Ibrahim Janahi (3744933)Biomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicsPaediatricsasthmachildrenlung clearance indexlung functionobesityventilation inhomogeneity<p dir="ltr">Asthma is more frequent and severe in individuals with obesity compared to those with normal weight. While inhomogeneity of lung ventilation due to distal airway obstruction is a key feature in asthma, the effect of obesity on ventilation homogeneity is unclear. We conducted a cross‐sectional study comparing lung clearance index (LCI) using multiple breath nitrogen washout technique between children with normal weight and asthma (<i>n</i> = 97), overweight/obesity and asthma (<i>n</i> = 100), overweight/obesity and no asthma (<i>n</i> = 100), and children with normal weight and no asthma (<i>n</i> = 67). Spirometry, lung volumes, and fractional exhaled nitric oxide (FeNO) were obtained for comparison. Results showed no significant difference in LCI between overweight/obesity groups and normal weight groups and no significant correlation between LCI and body mass index (BMI). However, LCI was higher in the asthma groups compared to non‐asthma groups (<i>p</i> = 0.017, <i>p</i> = 0.003). There was a significant negative correlation between LCI and FEV1% predicted, FEV1/FVC, and FEF25–75% predicted (<i>r </i>= −0.24, <i>p</i> < 0.001; <i>r </i>= −0.26, p< 0.001; r = −0.23, <i>p</i> < 0.001), and a positive correlation with RV/TLC (<i>r</i> = 0.17, p = 0.003) and FeNO (<i>r</i> = 0.29, <i>p</i>< 0.001). These findings indicate that obesity does not affect the homogeneity of lung ventilation. Therefore, alternative mechanisms should be considered to explain the association between asthma and obesity.</p><h2>Other Information</h2><p dir="ltr">Published in: Physiological Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.14814/phy2.70257" target="_blank">https://dx.doi.org/10.14814/phy2.70257</a></p>2025-04-17T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.14814/phy2.70257https://figshare.com/articles/journal_contribution/Inhomogeneity_of_lung_ventilation_in_children_with_obesity_and_its_potential_role_in_worsening_asthma/30405622CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/304056222025-04-17T09:00:00Z |
| spellingShingle | Inhomogeneity of lung ventilation in children with obesity and its potential role in worsening asthma Ahmed Abushahin (17337703) Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Paediatrics asthma children lung clearance index lung function obesity ventilation inhomogeneity |
| status_str | publishedVersion |
| title | Inhomogeneity of lung ventilation in children with obesity and its potential role in worsening asthma |
| title_full | Inhomogeneity of lung ventilation in children with obesity and its potential role in worsening asthma |
| title_fullStr | Inhomogeneity of lung ventilation in children with obesity and its potential role in worsening asthma |
| title_full_unstemmed | Inhomogeneity of lung ventilation in children with obesity and its potential role in worsening asthma |
| title_short | Inhomogeneity of lung ventilation in children with obesity and its potential role in worsening asthma |
| title_sort | Inhomogeneity of lung ventilation in children with obesity and its potential role in worsening asthma |
| topic | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Paediatrics asthma children lung clearance index lung function obesity ventilation inhomogeneity |