Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice
<p>Cadmium (Cd) is a harmful pollutant which mainly affects the liver and kidney. In this work, we investigated the hepatoprotective effects of olive leaf extract based on oleuropein against hepatic cadmium toxicity in mice. Three groups of animals were used: the first one served as the contro...
محفوظ في:
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2020
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إضافة وسم
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| _version_ | 1864513563303870464 |
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| author | Hedya Jemai (14571781) |
| author2 | Asma Mahmoudi (12996226) Anwar Feryeni (14571784) Ines Fki (14571787) Zouhaier Bouallagui (14571796) Sirine Choura (14571799) Mohamed Chamkha (11170403) Sami Sayadi (14571804) |
| author2_role | author author author author author author author |
| author_facet | Hedya Jemai (14571781) Asma Mahmoudi (12996226) Anwar Feryeni (14571784) Ines Fki (14571787) Zouhaier Bouallagui (14571796) Sirine Choura (14571799) Mohamed Chamkha (11170403) Sami Sayadi (14571804) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hedya Jemai (14571781) Asma Mahmoudi (12996226) Anwar Feryeni (14571784) Ines Fki (14571787) Zouhaier Bouallagui (14571796) Sirine Choura (14571799) Mohamed Chamkha (11170403) Sami Sayadi (14571804) |
| dc.date.none.fl_str_mv | 2020-04-20T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1155/2020/4398924 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Hepatoprotective_Effect_of_Oleuropein-Rich_Extract_from_Olive_Leaves_against_Cadmium-Induced_Toxicity_in_Mice/22015553 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Zoology Biomedical and clinical sciences Immunology General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine |
| dc.title.none.fl_str_mv | Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Cadmium (Cd) is a harmful pollutant which mainly affects the liver and kidney. In this work, we investigated the hepatoprotective effects of olive leaf extract based on oleuropein against hepatic cadmium toxicity in mice. Three groups of animals were used: the first one served as the control (C); the second one received intraperitoneal injection of cadmium 2 mg/kg b.w. (CD), administered five times during two weeks; and the third group received the same doses of Cd and simultaneously 16 mg/kg b.w. of oleuropein. Results showed that Cd induced a significant increase in liver injury biomarkers coupled with enhanced lipid peroxidation (MDA) and significant depletion of antioxidants (CAT and SOD). Histological and immunohistochemical analysis confirmed these findings. In fact, we observed a severe central lobular apoptosis and inflammation around central veins. Cotreatment with oleuropein significantly reduced the oxidative damage induced by cadmium. Our findings suggest that oleuropein could be used in the prevention of Cd hepatotoxicity. </p> <h2>Other information </h2> <p>Published in: BioMed Research International<br> License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br> See article on publisher's website: <a href="http://dx.doi.org/10.1155/2020/4398924" target="_blank">http://dx.doi.org/10.1155/2020/4398924</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b95e635055ccf12f1944f0276b01e9b4 |
| identifier_str_mv | 10.1155/2020/4398924 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22015553 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in MiceHedya Jemai (14571781)Asma Mahmoudi (12996226)Anwar Feryeni (14571784)Ines Fki (14571787)Zouhaier Bouallagui (14571796)Sirine Choura (14571799)Mohamed Chamkha (11170403)Sami Sayadi (14571804)ZoologyBiomedical and clinical sciencesImmunologyGeneral Immunology and MicrobiologyGeneral Biochemistry, Genetics and Molecular BiologyGeneral Medicine<p>Cadmium (Cd) is a harmful pollutant which mainly affects the liver and kidney. In this work, we investigated the hepatoprotective effects of olive leaf extract based on oleuropein against hepatic cadmium toxicity in mice. Three groups of animals were used: the first one served as the control (C); the second one received intraperitoneal injection of cadmium 2 mg/kg b.w. (CD), administered five times during two weeks; and the third group received the same doses of Cd and simultaneously 16 mg/kg b.w. of oleuropein. Results showed that Cd induced a significant increase in liver injury biomarkers coupled with enhanced lipid peroxidation (MDA) and significant depletion of antioxidants (CAT and SOD). Histological and immunohistochemical analysis confirmed these findings. In fact, we observed a severe central lobular apoptosis and inflammation around central veins. Cotreatment with oleuropein significantly reduced the oxidative damage induced by cadmium. Our findings suggest that oleuropein could be used in the prevention of Cd hepatotoxicity. </p> <h2>Other information </h2> <p>Published in: BioMed Research International<br> License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br> See article on publisher's website: <a href="http://dx.doi.org/10.1155/2020/4398924" target="_blank">http://dx.doi.org/10.1155/2020/4398924</a></p>2020-04-20T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1155/2020/4398924https://figshare.com/articles/journal_contribution/Hepatoprotective_Effect_of_Oleuropein-Rich_Extract_from_Olive_Leaves_against_Cadmium-Induced_Toxicity_in_Mice/22015553CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/220155532020-04-20T00:00:00Z |
| spellingShingle | Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice Hedya Jemai (14571781) Zoology Biomedical and clinical sciences Immunology General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine |
| status_str | publishedVersion |
| title | Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice |
| title_full | Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice |
| title_fullStr | Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice |
| title_full_unstemmed | Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice |
| title_short | Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice |
| title_sort | Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice |
| topic | Zoology Biomedical and clinical sciences Immunology General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology General Medicine |