Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity
<p><strong>Poster by Imran Ramzan, Moira Taylor, Kenneth Smith, Dan Wilkinson, Philip Atherton, and Iskandar Idris (University of Nottingham)</strong></p> <p>Background: Recent studies have identified branched chain amino acids (BCAAs; isoleucine, leucine and valine) as...
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2023
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| _version_ | 1864513564683796480 |
|---|---|
| author | Imran Ramzan (15430807) |
| author2 | Moira Taylor (10691746) Dan Wilkinson (15430818) Kenneth Smith (149075) Philip Atherton (88835) Iskandar Idris (2564347) |
| author2_role | author author author author author |
| author_facet | Imran Ramzan (15430807) Moira Taylor (10691746) Dan Wilkinson (15430818) Kenneth Smith (149075) Philip Atherton (88835) Iskandar Idris (2564347) |
| author_role | author |
| dc.creator.none.fl_str_mv | Imran Ramzan (15430807) Moira Taylor (10691746) Dan Wilkinson (15430818) Kenneth Smith (149075) Philip Atherton (88835) Iskandar Idris (2564347) |
| dc.date.none.fl_str_mv | 2023-05-17T11:54:18Z |
| dc.identifier.none.fl_str_mv | 10.57945/manara.22785509.v1 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/poster/Finding_novel_targets_for_the_treatment_and_reversal_of_type_2_diabetes_mellitus_and_obesity/22785509 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biotechnology Type 2 Diabetes Mellitus Obesity management Nutrition/diet Branched chain amino acids Biomarkers |
| dc.title.none.fl_str_mv | Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity |
| dc.type.none.fl_str_mv | Image Poster info:eu-repo/semantics/publishedVersion image |
| description | <p><strong>Poster by Imran Ramzan, Moira Taylor, Kenneth Smith, Dan Wilkinson, Philip Atherton, and Iskandar Idris (University of Nottingham)</strong></p> <p>Background: Recent studies have identified branched chain amino acids (BCAAs; isoleucine, leucine and valine) as potential biomarkers of, and being involved in, the pathogenesis of type 2 diabetes mellitus (T2DM), insulin resistance (IR) and obesity. Reducing circulatory BCAAs by dietary restriction was suggested to mitigate these risks in rodent models, but this is a challenging paradigm to deliver in humans.</p> <p>Objective: We aimed to design and assess the feasibility of a diet aimed at reducing circulating BCAA concentrations in humans, while maintaining energy balance and overall energy/protein intake. </p> <p>Methods: Twelve healthy individuals were assigned to either a 7-day BCAA-restricted diet or a 7-day control diet. Diets were iso-nitrogenous and iso-caloric, with only BCAA levels differing between the two.</p> <p>Results: The BCAA-restricted diet significantly reduced circulating BCAA concentrations by ~50% i.e., baseline 437 ± 60 to 217 ± 40 µmol/L (p < 0.005). Individually, both valine (245 ± 33 to 105 ± 23 µmol/L; p < 0.0001), and leucine (130 ± 20 to 75 ± 13 µmol/L; p < 0.05), decreased significantly in response to the BCAA-restricted diet. The BCAA-restricted diet marginally lowered Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) levels: baseline 1.5 ± 0.2 to 1.0 ± 0.1; (p = 0.096).</p> <p>Conclusion: We successfully lowered circulating BCAAs by 50% while maintaining iso-nitrogenous, iso-caloric dietary intakes, and while meeting the recommended daily allowances (RDA) for protein requirements. The present pilot study represents a novel dietary means by which to reduce BCAA, and as such, provides a blueprint for a potential dietary therapeutic in obesity/diabetes.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_b963d6487204e2192d3168a45ca1d274 |
| identifier_str_mv | 10.57945/manara.22785509.v1 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22785509 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesityImran Ramzan (15430807)Moira Taylor (10691746)Dan Wilkinson (15430818)Kenneth Smith (149075)Philip Atherton (88835)Iskandar Idris (2564347)Biomedical and clinical sciencesMedical biotechnologyType 2 Diabetes MellitusObesity managementNutrition/dietBranched chain amino acidsBiomarkers<p><strong>Poster by Imran Ramzan, Moira Taylor, Kenneth Smith, Dan Wilkinson, Philip Atherton, and Iskandar Idris (University of Nottingham)</strong></p> <p>Background: Recent studies have identified branched chain amino acids (BCAAs; isoleucine, leucine and valine) as potential biomarkers of, and being involved in, the pathogenesis of type 2 diabetes mellitus (T2DM), insulin resistance (IR) and obesity. Reducing circulatory BCAAs by dietary restriction was suggested to mitigate these risks in rodent models, but this is a challenging paradigm to deliver in humans.</p> <p>Objective: We aimed to design and assess the feasibility of a diet aimed at reducing circulating BCAA concentrations in humans, while maintaining energy balance and overall energy/protein intake. </p> <p>Methods: Twelve healthy individuals were assigned to either a 7-day BCAA-restricted diet or a 7-day control diet. Diets were iso-nitrogenous and iso-caloric, with only BCAA levels differing between the two.</p> <p>Results: The BCAA-restricted diet significantly reduced circulating BCAA concentrations by ~50% i.e., baseline 437 ± 60 to 217 ± 40 µmol/L (p < 0.005). Individually, both valine (245 ± 33 to 105 ± 23 µmol/L; p < 0.0001), and leucine (130 ± 20 to 75 ± 13 µmol/L; p < 0.05), decreased significantly in response to the BCAA-restricted diet. The BCAA-restricted diet marginally lowered Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) levels: baseline 1.5 ± 0.2 to 1.0 ± 0.1; (p = 0.096).</p> <p>Conclusion: We successfully lowered circulating BCAAs by 50% while maintaining iso-nitrogenous, iso-caloric dietary intakes, and while meeting the recommended daily allowances (RDA) for protein requirements. The present pilot study represents a novel dietary means by which to reduce BCAA, and as such, provides a blueprint for a potential dietary therapeutic in obesity/diabetes.</p>2023-05-17T11:54:18ZImagePosterinfo:eu-repo/semantics/publishedVersionimage10.57945/manara.22785509.v1https://figshare.com/articles/poster/Finding_novel_targets_for_the_treatment_and_reversal_of_type_2_diabetes_mellitus_and_obesity/22785509CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/227855092023-05-17T11:54:18Z |
| spellingShingle | Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity Imran Ramzan (15430807) Biomedical and clinical sciences Medical biotechnology Type 2 Diabetes Mellitus Obesity management Nutrition/diet Branched chain amino acids Biomarkers |
| status_str | publishedVersion |
| title | Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity |
| title_full | Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity |
| title_fullStr | Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity |
| title_full_unstemmed | Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity |
| title_short | Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity |
| title_sort | Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity |
| topic | Biomedical and clinical sciences Medical biotechnology Type 2 Diabetes Mellitus Obesity management Nutrition/diet Branched chain amino acids Biomarkers |