Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis
<p></p><div> <h3> Background</h3> <p>Colchicine was recently repurposed for the management of coronavirus disease 2019 (COVID-19). This rapid review and meta-analysis aimed to assess colchicine's impact on mortality outcomes in COVID-19 patients.</p> &l...
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2023
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| _version_ | 1864513566161240064 |
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| author | Mohamed Nabil Elshafei (9960500) |
| author2 | Ahmed El‐Bardissy (14777851) Ahmed Khalil (2132113) Mohammed Danjuma (9960506) Mahmood Mubasher (14570517) Ibrahim Y. Abubeker (9960503) Mouhand F. H. Mohamed (9617052) |
| author2_role | author author author author author author |
| author_facet | Mohamed Nabil Elshafei (9960500) Ahmed El‐Bardissy (14777851) Ahmed Khalil (2132113) Mohammed Danjuma (9960506) Mahmood Mubasher (14570517) Ibrahim Y. Abubeker (9960503) Mouhand F. H. Mohamed (9617052) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mohamed Nabil Elshafei (9960500) Ahmed El‐Bardissy (14777851) Ahmed Khalil (2132113) Mohammed Danjuma (9960506) Mahmood Mubasher (14570517) Ibrahim Y. Abubeker (9960503) Mouhand F. H. Mohamed (9617052) |
| dc.date.none.fl_str_mv | 2023-03-15T12:53:55Z |
| dc.identifier.none.fl_str_mv | 10.1111/eci.13645 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Colchicine_use_might_be_associated_with_lower_mortality_in_COVID_19_patients_A_meta_analysis/22258492 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Clinical Biochemistry Biochemistry General Medicine |
| dc.title.none.fl_str_mv | Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p></p><div> <h3> Background</h3> <p>Colchicine was recently repurposed for the management of coronavirus disease 2019 (COVID-19). This rapid review and meta-analysis aimed to assess colchicine's impact on mortality outcomes in COVID-19 patients.</p> <h3> Materials and Methods</h3> <p>We systematically searched PubMed, EMBASE, Google Scholar since their inception till 25/03/2021 for observational or controlled studies that reported mortality as an outcome. The mortality odd ratios were generated with their corresponding 95% confidence intervals utilizing the random-effects model.</p> <h3> Results</h3> <p>Nine studies comprising 5522 patients met our inclusion criteria. Our meta-analysis revealed significantly lower mortality in the colchicine group (OR 0.35, 95% CI 0.25-0.48, I2 0%) compared with controls. A subgroup analysis limited to hospitalized patients (OR 0.35, 95% CI 0.25-0.50, I2 0%) revealed similarly lower mortality in the colchicine group.</p> <h3> Conclusions</h3> <p>This meta-analysis suggests a mortality benefit with colchicine when used in the treatment of COVID-19 patients. The majority of included studies were observational; thus, the findings of this review need to be further supported by the results of ongoing trials.</p> </div><p></p><h2>Other Information</h2> <p> Published in: European Journal of Clinical Investigation<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1111/eci.13645" target="_blank">http://dx.doi.org/10.1111/eci.13645</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ba2bd941b026916f94264116f4a8209d |
| identifier_str_mv | 10.1111/eci.13645 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22258492 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysisMohamed Nabil Elshafei (9960500)Ahmed El‐Bardissy (14777851)Ahmed Khalil (2132113)Mohammed Danjuma (9960506)Mahmood Mubasher (14570517)Ibrahim Y. Abubeker (9960503)Mouhand F. H. Mohamed (9617052)Biomedical and clinical sciencesMedical biochemistry and metabolomicsClinical BiochemistryBiochemistryGeneral Medicine<p></p><div> <h3> Background</h3> <p>Colchicine was recently repurposed for the management of coronavirus disease 2019 (COVID-19). This rapid review and meta-analysis aimed to assess colchicine's impact on mortality outcomes in COVID-19 patients.</p> <h3> Materials and Methods</h3> <p>We systematically searched PubMed, EMBASE, Google Scholar since their inception till 25/03/2021 for observational or controlled studies that reported mortality as an outcome. The mortality odd ratios were generated with their corresponding 95% confidence intervals utilizing the random-effects model.</p> <h3> Results</h3> <p>Nine studies comprising 5522 patients met our inclusion criteria. Our meta-analysis revealed significantly lower mortality in the colchicine group (OR 0.35, 95% CI 0.25-0.48, I2 0%) compared with controls. A subgroup analysis limited to hospitalized patients (OR 0.35, 95% CI 0.25-0.50, I2 0%) revealed similarly lower mortality in the colchicine group.</p> <h3> Conclusions</h3> <p>This meta-analysis suggests a mortality benefit with colchicine when used in the treatment of COVID-19 patients. The majority of included studies were observational; thus, the findings of this review need to be further supported by the results of ongoing trials.</p> </div><p></p><h2>Other Information</h2> <p> Published in: European Journal of Clinical Investigation<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1111/eci.13645" target="_blank">http://dx.doi.org/10.1111/eci.13645</a></p>2023-03-15T12:53:55ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1111/eci.13645https://figshare.com/articles/journal_contribution/Colchicine_use_might_be_associated_with_lower_mortality_in_COVID_19_patients_A_meta_analysis/22258492CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/222584922023-03-15T12:53:55Z |
| spellingShingle | Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis Mohamed Nabil Elshafei (9960500) Biomedical and clinical sciences Medical biochemistry and metabolomics Clinical Biochemistry Biochemistry General Medicine |
| status_str | publishedVersion |
| title | Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis |
| title_full | Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis |
| title_fullStr | Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis |
| title_full_unstemmed | Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis |
| title_short | Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis |
| title_sort | Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Clinical Biochemistry Biochemistry General Medicine |