Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs
<p dir="ltr">Purpose: This study aimed to assess the potential of flavonoids in combating CIPN. Methods: PubMed and Google Scholar were used, and studies that investigated flavonoids in models of CIPN and models of neuropathic pain similar to CIPN were included. Only studies investig...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , |
| منشور في: |
2021
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513511933083648 |
|---|---|
| author | Manaal Siddiqui (18891637) |
| author2 | Basma Abdellatif (12628165) Kevin Zhai (18877843) Alena Liskova (11008851) Peter Kubatka (11008854) Dietrich Büsselberg (11008857) |
| author2_role | author author author author author |
| author_facet | Manaal Siddiqui (18891637) Basma Abdellatif (12628165) Kevin Zhai (18877843) Alena Liskova (11008851) Peter Kubatka (11008854) Dietrich Büsselberg (11008857) |
| author_role | author |
| dc.creator.none.fl_str_mv | Manaal Siddiqui (18891637) Basma Abdellatif (12628165) Kevin Zhai (18877843) Alena Liskova (11008851) Peter Kubatka (11008854) Dietrich Büsselberg (11008857) |
| dc.date.none.fl_str_mv | 2021-03-29T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/cancers13071576 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Flavonoids_Alleviate_Peripheral_Neuropathy_Induced_by_Anticancer_Drugs/26114332 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry flavonoids CIPN chemotherapy peripheral neuropathy |
| dc.title.none.fl_str_mv | Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Purpose: This study aimed to assess the potential of flavonoids in combating CIPN. Methods: PubMed and Google Scholar were used, and studies that investigated flavonoids in models of CIPN and models of neuropathic pain similar to CIPN were included. Only studies investigating peripheral mechanisms of CIPN were used. Results: Flavonoids inhibit several essential mechanisms of CIPN, such as proinflammatory cytokine release, astrocyte and microglial activation, oxidative stress, neuronal damage and apoptosis, mitochondrial damage, ectopic discharge, and ion channel activation. They decreased the severity of certain CIPN symptoms, such as thermal hyperalgesia and mechanical, tactile, and cold allodynia. Conclusions: Flavonoids hold immense promise in treating CIPN; thus, future research should investigate their effects in humans. Specifically, precise pharmacological mechanisms and side effects need to be elucidated in human models before clinical benefits can be achieved.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancers<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers13071576" target="_blank">https://dx.doi.org/10.3390/cancers13071576</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ba32e8b1a056171b11d927b5a63e5e9e |
| identifier_str_mv | 10.3390/cancers13071576 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26114332 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer DrugsManaal Siddiqui (18891637)Basma Abdellatif (12628165)Kevin Zhai (18877843)Alena Liskova (11008851)Peter Kubatka (11008854)Dietrich Büsselberg (11008857)Biomedical and clinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesChemical sciencesMedicinal and biomolecular chemistryflavonoidsCIPNchemotherapyperipheral neuropathy<p dir="ltr">Purpose: This study aimed to assess the potential of flavonoids in combating CIPN. Methods: PubMed and Google Scholar were used, and studies that investigated flavonoids in models of CIPN and models of neuropathic pain similar to CIPN were included. Only studies investigating peripheral mechanisms of CIPN were used. Results: Flavonoids inhibit several essential mechanisms of CIPN, such as proinflammatory cytokine release, astrocyte and microglial activation, oxidative stress, neuronal damage and apoptosis, mitochondrial damage, ectopic discharge, and ion channel activation. They decreased the severity of certain CIPN symptoms, such as thermal hyperalgesia and mechanical, tactile, and cold allodynia. Conclusions: Flavonoids hold immense promise in treating CIPN; thus, future research should investigate their effects in humans. Specifically, precise pharmacological mechanisms and side effects need to be elucidated in human models before clinical benefits can be achieved.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancers<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers13071576" target="_blank">https://dx.doi.org/10.3390/cancers13071576</a></p>2021-03-29T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/cancers13071576https://figshare.com/articles/journal_contribution/Flavonoids_Alleviate_Peripheral_Neuropathy_Induced_by_Anticancer_Drugs/26114332CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/261143322021-03-29T06:00:00Z |
| spellingShingle | Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs Manaal Siddiqui (18891637) Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry flavonoids CIPN chemotherapy peripheral neuropathy |
| status_str | publishedVersion |
| title | Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs |
| title_full | Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs |
| title_fullStr | Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs |
| title_full_unstemmed | Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs |
| title_short | Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs |
| title_sort | Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry flavonoids CIPN chemotherapy peripheral neuropathy |