Inhibitors of riboflavin biosynthetic pathway enzymes as potential antibacterial drugs
<p dir="ltr">Multiple drug resistance is the main obstacle in the treatment of bacterial diseases. Resistance against antibiotics demands the exploration of new antimicrobial drug targets. A variety of in silico and genetic approaches show that the enzymes of the riboflavin biosynthe...
محفوظ في:
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| مؤلفون آخرون: | |
| منشور في: |
2023
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513508187570176 |
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| author | Zeyaul Islam (5867387) |
| author2 | Pankaj Kumar (63234) |
| author2_role | author |
| author_facet | Zeyaul Islam (5867387) Pankaj Kumar (63234) |
| author_role | author |
| dc.creator.none.fl_str_mv | Zeyaul Islam (5867387) Pankaj Kumar (63234) |
| dc.date.none.fl_str_mv | 2023-07-11T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fmolb.2023.1228763 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Inhibitors_of_riboflavin_biosynthetic_pathway_enzymes_as_potential_antibacterial_drugs/26569909 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Clinical sciences riboflavin biosynthetic pathway inhibitors 3,4-dihydroxy-2-butanone 4-phosphate synthase lumazine synthase riboflavin synthase |
| dc.title.none.fl_str_mv | Inhibitors of riboflavin biosynthetic pathway enzymes as potential antibacterial drugs |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Multiple drug resistance is the main obstacle in the treatment of bacterial diseases. Resistance against antibiotics demands the exploration of new antimicrobial drug targets. A variety of in silico and genetic approaches show that the enzymes of the riboflavin biosynthetic pathway are crucial for the survival of bacteria. This pathway is absent in humans thus enzymes of the riboflavin biosynthetic pathway are emerging drug targets for resistant pathogenic bacterial strains. Exploring the structural details, their mechanism of action, intermediate elucidation, and interaction analysis would help in designing suitable inhibitors of these enzymes. The riboflavin biosynthetic pathway consists of seven distinct enzymes, namely, 3,4-dihydroxy-2-butanone 4-phosphate synthase, GTP cyclohydrolase II, pyrimidine deaminase/reductase, phosphatase, lumazine synthase, and riboflavin synthase. The present review summarizes the research work that has been carried out on these enzymes in terms of their structures, active site architectures, and molecular mechanism of catalysis. This review also walks through small molecule inhibitors that have been developed against several of these enzymes.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Molecular Biosciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fmolb.2023.1228763" target="_blank">https://dx.doi.org/10.3389/fmolb.2023.1228763</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_bb99e39d9f87419495e2ef6f9ceadc23 |
| identifier_str_mv | 10.3389/fmolb.2023.1228763 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26569909 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Inhibitors of riboflavin biosynthetic pathway enzymes as potential antibacterial drugsZeyaul Islam (5867387)Pankaj Kumar (63234)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesClinical sciencesriboflavin biosynthetic pathwayinhibitors3,4-dihydroxy-2-butanone 4-phosphate synthaselumazine synthaseriboflavin synthase<p dir="ltr">Multiple drug resistance is the main obstacle in the treatment of bacterial diseases. Resistance against antibiotics demands the exploration of new antimicrobial drug targets. A variety of in silico and genetic approaches show that the enzymes of the riboflavin biosynthetic pathway are crucial for the survival of bacteria. This pathway is absent in humans thus enzymes of the riboflavin biosynthetic pathway are emerging drug targets for resistant pathogenic bacterial strains. Exploring the structural details, their mechanism of action, intermediate elucidation, and interaction analysis would help in designing suitable inhibitors of these enzymes. The riboflavin biosynthetic pathway consists of seven distinct enzymes, namely, 3,4-dihydroxy-2-butanone 4-phosphate synthase, GTP cyclohydrolase II, pyrimidine deaminase/reductase, phosphatase, lumazine synthase, and riboflavin synthase. The present review summarizes the research work that has been carried out on these enzymes in terms of their structures, active site architectures, and molecular mechanism of catalysis. This review also walks through small molecule inhibitors that have been developed against several of these enzymes.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Molecular Biosciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fmolb.2023.1228763" target="_blank">https://dx.doi.org/10.3389/fmolb.2023.1228763</a></p>2023-07-11T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fmolb.2023.1228763https://figshare.com/articles/journal_contribution/Inhibitors_of_riboflavin_biosynthetic_pathway_enzymes_as_potential_antibacterial_drugs/26569909CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/265699092023-07-11T09:00:00Z |
| spellingShingle | Inhibitors of riboflavin biosynthetic pathway enzymes as potential antibacterial drugs Zeyaul Islam (5867387) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Clinical sciences riboflavin biosynthetic pathway inhibitors 3,4-dihydroxy-2-butanone 4-phosphate synthase lumazine synthase riboflavin synthase |
| status_str | publishedVersion |
| title | Inhibitors of riboflavin biosynthetic pathway enzymes as potential antibacterial drugs |
| title_full | Inhibitors of riboflavin biosynthetic pathway enzymes as potential antibacterial drugs |
| title_fullStr | Inhibitors of riboflavin biosynthetic pathway enzymes as potential antibacterial drugs |
| title_full_unstemmed | Inhibitors of riboflavin biosynthetic pathway enzymes as potential antibacterial drugs |
| title_short | Inhibitors of riboflavin biosynthetic pathway enzymes as potential antibacterial drugs |
| title_sort | Inhibitors of riboflavin biosynthetic pathway enzymes as potential antibacterial drugs |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Clinical sciences riboflavin biosynthetic pathway inhibitors 3,4-dihydroxy-2-butanone 4-phosphate synthase lumazine synthase riboflavin synthase |