Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application
<p dir="ltr">Tumor angiogenesis is regulated by the binding of VEGF to receptors (VEGFRs). The major mediator of tumor angiogenesis is VEGFA, more commonly referred to as VEGF. VEGFR1 binds VEGF with higher affinity (10 times) than VEGFR2.<a href="https://www.nature.com/artic...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , , , , |
| Published: |
2020
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513516134727680 |
|---|---|
| author | Afsaneh Sadremomtaz (11210280) |
| author2 | Ameena M. Ali (18550873) Foroozan Jouyandeh (18550876) Saeed Balalaie (1754095) Razieh Navari (4545583) Sylvain Broussy (1663198) Kamran Mansouri (2933658) Matthew R. Groves (8861588) S. Mohsen Asghari (17443947) |
| author2_role | author author author author author author author author |
| author_facet | Afsaneh Sadremomtaz (11210280) Ameena M. Ali (18550873) Foroozan Jouyandeh (18550876) Saeed Balalaie (1754095) Razieh Navari (4545583) Sylvain Broussy (1663198) Kamran Mansouri (2933658) Matthew R. Groves (8861588) S. Mohsen Asghari (17443947) |
| author_role | author |
| dc.creator.none.fl_str_mv | Afsaneh Sadremomtaz (11210280) Ameena M. Ali (18550873) Foroozan Jouyandeh (18550876) Saeed Balalaie (1754095) Razieh Navari (4545583) Sylvain Broussy (1663198) Kamran Mansouri (2933658) Matthew R. Groves (8861588) S. Mohsen Asghari (17443947) |
| dc.date.none.fl_str_mv | 2020-06-05T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41392-020-0177-z |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Molecular_docking_synthesis_and_biological_evaluation_of_Vascular_Endothelial_Growth_Factor_VEGF_B_based_peptide_as_antiangiogenic_agent_targeting_the_second_domain_of_the_Vascular_Endothelial_Growth_Factor_Receptor_1_VEGFR1D2_for_anticance/25815793 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Chemical sciences Medicinal and biomolecular chemistry Tumor angiogenesis VEGF (Vascular Endothelial Growth Factor) VEGFR (Vascular Endothelial Growth Factor Receptor) Protein purification VEGF receptor binding peptide |
| dc.title.none.fl_str_mv | Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Tumor angiogenesis is regulated by the binding of VEGF to receptors (VEGFRs). The major mediator of tumor angiogenesis is VEGFA, more commonly referred to as VEGF. VEGFR1 binds VEGF with higher affinity (10 times) than VEGFR2.<a href="https://www.nature.com/articles/s41392-020-0177-z#ref-CR1" target="_blank">1</a> However, the role of the VEGFR1 in VEGF-mediated angiogenesis remains a mystery.</p><h2>Other Information</h2><p dir="ltr">Published in: Signal Transduction and Targeted Therapy<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41392-020-0177-z" target="_blank">https://dx.doi.org/10.1038/s41392-020-0177-z</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_bc5139ad09e4992c59cf43c42399cd69 |
| identifier_str_mv | 10.1038/s41392-020-0177-z |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25815793 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer applicationAfsaneh Sadremomtaz (11210280)Ameena M. Ali (18550873)Foroozan Jouyandeh (18550876)Saeed Balalaie (1754095)Razieh Navari (4545583)Sylvain Broussy (1663198)Kamran Mansouri (2933658)Matthew R. Groves (8861588)S. Mohsen Asghari (17443947)Biomedical and clinical sciencesOncology and carcinogenesisChemical sciencesMedicinal and biomolecular chemistryTumor angiogenesisVEGF (Vascular Endothelial Growth Factor)VEGFR (Vascular Endothelial Growth Factor Receptor)Protein purificationVEGF receptor binding peptide<p dir="ltr">Tumor angiogenesis is regulated by the binding of VEGF to receptors (VEGFRs). The major mediator of tumor angiogenesis is VEGFA, more commonly referred to as VEGF. VEGFR1 binds VEGF with higher affinity (10 times) than VEGFR2.<a href="https://www.nature.com/articles/s41392-020-0177-z#ref-CR1" target="_blank">1</a> However, the role of the VEGFR1 in VEGF-mediated angiogenesis remains a mystery.</p><h2>Other Information</h2><p dir="ltr">Published in: Signal Transduction and Targeted Therapy<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41392-020-0177-z" target="_blank">https://dx.doi.org/10.1038/s41392-020-0177-z</a></p>2020-06-05T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41392-020-0177-zhttps://figshare.com/articles/journal_contribution/Molecular_docking_synthesis_and_biological_evaluation_of_Vascular_Endothelial_Growth_Factor_VEGF_B_based_peptide_as_antiangiogenic_agent_targeting_the_second_domain_of_the_Vascular_Endothelial_Growth_Factor_Receptor_1_VEGFR1D2_for_anticance/25815793CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/258157932020-06-05T03:00:00Z |
| spellingShingle | Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application Afsaneh Sadremomtaz (11210280) Biomedical and clinical sciences Oncology and carcinogenesis Chemical sciences Medicinal and biomolecular chemistry Tumor angiogenesis VEGF (Vascular Endothelial Growth Factor) VEGFR (Vascular Endothelial Growth Factor Receptor) Protein purification VEGF receptor binding peptide |
| status_str | publishedVersion |
| title | Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application |
| title_full | Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application |
| title_fullStr | Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application |
| title_full_unstemmed | Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application |
| title_short | Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application |
| title_sort | Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Chemical sciences Medicinal and biomolecular chemistry Tumor angiogenesis VEGF (Vascular Endothelial Growth Factor) VEGFR (Vascular Endothelial Growth Factor Receptor) Protein purification VEGF receptor binding peptide |