Recent developments in unraveling signaling mechanisms underlying drug resistance due to cancer stem-like cells
<p dir="ltr">Resistance in cancer cells to therapeutic measures is challenging and requires a rigorous delineation of the underlying mechanisms. Emerging findings reflect the characteristics of tumor cells to do the reprogramming of signaling machinery in order to overturn the therap...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , |
| منشور في: |
2020
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513559053991936 |
|---|---|
| author | Abdul Q Khan (17075287) |
| author2 | Khalid Rashid (10199826) Abdulhadi A AlAmodi (12229415) Syed Shadab Raza (5775911) Shahab Uddin (154400) |
| author2_role | author author author author |
| author_facet | Abdul Q Khan (17075287) Khalid Rashid (10199826) Abdulhadi A AlAmodi (12229415) Syed Shadab Raza (5775911) Shahab Uddin (154400) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdul Q Khan (17075287) Khalid Rashid (10199826) Abdulhadi A AlAmodi (12229415) Syed Shadab Raza (5775911) Shahab Uddin (154400) |
| dc.date.none.fl_str_mv | 2020-10-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.coph.2020.09.012 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Recent_developments_in_unraveling_signaling_mechanisms_underlying_drug_resistance_due_to_cancer_stem-like_cells/24225685 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences developments mechanisms drug resistance cancer cells |
| dc.title.none.fl_str_mv | Recent developments in unraveling signaling mechanisms underlying drug resistance due to cancer stem-like cells |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Resistance in cancer cells to therapeutic measures is challenging and requires a rigorous delineation of the underlying mechanisms. Emerging findings reflect the characteristics of tumor cells to do the reprogramming of signaling machinery in order to overturn the therapeutic responses. Recent evidence shows that the tumor acquires drug resistance due to the presence of cancer stem cells (CSCs). Hence the understanding that how tumor cells reprogram their signaling mechanisms converging towards the stemness of CSCs is imperative for novel and effective therapy. This review outlines the current updates on how CSC-associated signaling pathways and its enhanced stemness trigger the development of drug resistance. Furthermore, we also discussed the strategies with a combinational approach that can simultaneously target both CSC-induced stemness and the resistance-related signaling pathways, which may provide an optimal outcome to overcome the problem of drug resistance in cancer therapy.</p><h2>Other Information</h2><p dir="ltr">Published in: Current Opinion in Pharmacology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.coph.2020.09.012" target="_blank">https://dx.doi.org/10.1016/j.coph.2020.09.012</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_bc6c3e4988ff860344015cf35b000fb4 |
| identifier_str_mv | 10.1016/j.coph.2020.09.012 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24225685 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Recent developments in unraveling signaling mechanisms underlying drug resistance due to cancer stem-like cellsAbdul Q Khan (17075287)Khalid Rashid (10199826)Abdulhadi A AlAmodi (12229415)Syed Shadab Raza (5775911)Shahab Uddin (154400)Biomedical and clinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesdevelopmentsmechanismsdrug resistancecancercells<p dir="ltr">Resistance in cancer cells to therapeutic measures is challenging and requires a rigorous delineation of the underlying mechanisms. Emerging findings reflect the characteristics of tumor cells to do the reprogramming of signaling machinery in order to overturn the therapeutic responses. Recent evidence shows that the tumor acquires drug resistance due to the presence of cancer stem cells (CSCs). Hence the understanding that how tumor cells reprogram their signaling mechanisms converging towards the stemness of CSCs is imperative for novel and effective therapy. This review outlines the current updates on how CSC-associated signaling pathways and its enhanced stemness trigger the development of drug resistance. Furthermore, we also discussed the strategies with a combinational approach that can simultaneously target both CSC-induced stemness and the resistance-related signaling pathways, which may provide an optimal outcome to overcome the problem of drug resistance in cancer therapy.</p><h2>Other Information</h2><p dir="ltr">Published in: Current Opinion in Pharmacology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.coph.2020.09.012" target="_blank">https://dx.doi.org/10.1016/j.coph.2020.09.012</a></p>2020-10-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.coph.2020.09.012https://figshare.com/articles/journal_contribution/Recent_developments_in_unraveling_signaling_mechanisms_underlying_drug_resistance_due_to_cancer_stem-like_cells/24225685CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/242256852020-10-01T00:00:00Z |
| spellingShingle | Recent developments in unraveling signaling mechanisms underlying drug resistance due to cancer stem-like cells Abdul Q Khan (17075287) Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences developments mechanisms drug resistance cancer cells |
| status_str | publishedVersion |
| title | Recent developments in unraveling signaling mechanisms underlying drug resistance due to cancer stem-like cells |
| title_full | Recent developments in unraveling signaling mechanisms underlying drug resistance due to cancer stem-like cells |
| title_fullStr | Recent developments in unraveling signaling mechanisms underlying drug resistance due to cancer stem-like cells |
| title_full_unstemmed | Recent developments in unraveling signaling mechanisms underlying drug resistance due to cancer stem-like cells |
| title_short | Recent developments in unraveling signaling mechanisms underlying drug resistance due to cancer stem-like cells |
| title_sort | Recent developments in unraveling signaling mechanisms underlying drug resistance due to cancer stem-like cells |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences developments mechanisms drug resistance cancer cells |