A systematic review of the clinical characteristics and course of atrioventricular blocks in hyperthyroidism
<h3>Background</h3><p dir="ltr">Atrioventricular block (AVB) is rare in hyperthyroidism (HTH). Little is known about the true prevalence, clinical course, optimal management, and outcomes of different types of AVBs in patients with HTH. To address these uncertainties, we...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2024
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إضافة وسم
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| _version_ | 1864513541999951872 |
|---|---|
| author | Fateen Ata (12217764) |
| author2 | Haseeb Ahmad Khan (11820017) Hassan Choudry (12217767) Adeel Ahmad Khan (14152953) Shuja Tahir (17542536) Tiago Lemos Cerqueira (12855521) Ben Illigens (846757) |
| author2_role | author author author author author author |
| author_facet | Fateen Ata (12217764) Haseeb Ahmad Khan (11820017) Hassan Choudry (12217767) Adeel Ahmad Khan (14152953) Shuja Tahir (17542536) Tiago Lemos Cerqueira (12855521) Ben Illigens (846757) |
| author_role | author |
| dc.creator.none.fl_str_mv | Fateen Ata (12217764) Haseeb Ahmad Khan (11820017) Hassan Choudry (12217767) Adeel Ahmad Khan (14152953) Shuja Tahir (17542536) Tiago Lemos Cerqueira (12855521) Ben Illigens (846757) |
| dc.date.none.fl_str_mv | 2024-06-21T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1080/07853890.2024.2365405 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/A_systematic_review_of_the_clinical_characteristics_and_course_of_atrioventricular_blocks_in_hyperthyroidism/29898680 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Medical biochemistry and metabolomics Hyperthyroidism Grave’s disease multinodular goitre thyroid heart block AV block atrioventricular blocks |
| dc.title.none.fl_str_mv | A systematic review of the clinical characteristics and course of atrioventricular blocks in hyperthyroidism |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Atrioventricular block (AVB) is rare in hyperthyroidism (HTH). Little is known about the true prevalence, clinical course, optimal management, and outcomes of different types of AVBs in patients with HTH. To address these uncertainties, we aimed to conduct a systematic review by combining the available literature to provide more meaningful data regarding AVBs in HTH.</p><h3>Methods</h3><p dir="ltr">We systematically searched PubMed, Scopus, Embase, and Google Scholar for articles reporting patients who developed AVB in the context of HTH. Data were analysed in STATA 16. The main outcomes included types of AVB, frequency of pacemaker insertion, and resolution of AVB. The systematic review is registered with the International Prospective Register of Systematic Reviews (PROSPERO) with the identification number CRD42022335598.</p><h3>Results</h3><p dir="ltr">A total of 56 studies (39 case reports, 12 case series, 3 conference abstracts, 1 retrospective study, and 1 prospective observational study) with 87 patients were included in the analysis, with a mean age of 39.1 ± 17.6 years. Females constituted 65.7% (n = 48) of the cohort. Complete heart block (CHB) was the most commonly reported AVB (N = 45, 51.7%), followed by first-degree AVB (16.1%) and second-degree AVB (14.9%). Overall, 21 patients underwent pacing. A permanent pacemaker was inserted in one patient with second-degree AVB and six patients with CHB. Mortality was reported in one patient with CHB. The clinical course and management of HTH and AVBs did not differ in patients with CHB or lower-degree blocks. Apart from lower rates of goitre and more use of carbimazole in those who underwent pacing, no differences were found when compared to the patients managed without pacing.</p><h3>Conclusion</h3><p dir="ltr">Current data suggest that CHB is the most common type of AVB in patients with HTH. Most patients can be managed with anti-thyroid management alone. Additionally, whether pacemaker insertion alters the clinical outcomes needs further exploration.</p><h2>Other Information</h2><p dir="ltr">Published in: Annals of Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1080/07853890.2024.2365405" target="_blank">https://dx.doi.org/10.1080/07853890.2024.2365405</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_bcf8ef6c6ee1a57412a89af89c550c8f |
| identifier_str_mv | 10.1080/07853890.2024.2365405 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29898680 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A systematic review of the clinical characteristics and course of atrioventricular blocks in hyperthyroidismFateen Ata (12217764)Haseeb Ahmad Khan (11820017)Hassan Choudry (12217767)Adeel Ahmad Khan (14152953)Shuja Tahir (17542536)Tiago Lemos Cerqueira (12855521)Ben Illigens (846757)Biomedical and clinical sciencesCardiovascular medicine and haematologyMedical biochemistry and metabolomicsHyperthyroidismGrave’s diseasemultinodular goitrethyroidheart blockAV blockatrioventricular blocks<h3>Background</h3><p dir="ltr">Atrioventricular block (AVB) is rare in hyperthyroidism (HTH). Little is known about the true prevalence, clinical course, optimal management, and outcomes of different types of AVBs in patients with HTH. To address these uncertainties, we aimed to conduct a systematic review by combining the available literature to provide more meaningful data regarding AVBs in HTH.</p><h3>Methods</h3><p dir="ltr">We systematically searched PubMed, Scopus, Embase, and Google Scholar for articles reporting patients who developed AVB in the context of HTH. Data were analysed in STATA 16. The main outcomes included types of AVB, frequency of pacemaker insertion, and resolution of AVB. The systematic review is registered with the International Prospective Register of Systematic Reviews (PROSPERO) with the identification number CRD42022335598.</p><h3>Results</h3><p dir="ltr">A total of 56 studies (39 case reports, 12 case series, 3 conference abstracts, 1 retrospective study, and 1 prospective observational study) with 87 patients were included in the analysis, with a mean age of 39.1 ± 17.6 years. Females constituted 65.7% (n = 48) of the cohort. Complete heart block (CHB) was the most commonly reported AVB (N = 45, 51.7%), followed by first-degree AVB (16.1%) and second-degree AVB (14.9%). Overall, 21 patients underwent pacing. A permanent pacemaker was inserted in one patient with second-degree AVB and six patients with CHB. Mortality was reported in one patient with CHB. The clinical course and management of HTH and AVBs did not differ in patients with CHB or lower-degree blocks. Apart from lower rates of goitre and more use of carbimazole in those who underwent pacing, no differences were found when compared to the patients managed without pacing.</p><h3>Conclusion</h3><p dir="ltr">Current data suggest that CHB is the most common type of AVB in patients with HTH. Most patients can be managed with anti-thyroid management alone. Additionally, whether pacemaker insertion alters the clinical outcomes needs further exploration.</p><h2>Other Information</h2><p dir="ltr">Published in: Annals of Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1080/07853890.2024.2365405" target="_blank">https://dx.doi.org/10.1080/07853890.2024.2365405</a></p>2024-06-21T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1080/07853890.2024.2365405https://figshare.com/articles/journal_contribution/A_systematic_review_of_the_clinical_characteristics_and_course_of_atrioventricular_blocks_in_hyperthyroidism/29898680CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/298986802024-06-21T06:00:00Z |
| spellingShingle | A systematic review of the clinical characteristics and course of atrioventricular blocks in hyperthyroidism Fateen Ata (12217764) Biomedical and clinical sciences Cardiovascular medicine and haematology Medical biochemistry and metabolomics Hyperthyroidism Grave’s disease multinodular goitre thyroid heart block AV block atrioventricular blocks |
| status_str | publishedVersion |
| title | A systematic review of the clinical characteristics and course of atrioventricular blocks in hyperthyroidism |
| title_full | A systematic review of the clinical characteristics and course of atrioventricular blocks in hyperthyroidism |
| title_fullStr | A systematic review of the clinical characteristics and course of atrioventricular blocks in hyperthyroidism |
| title_full_unstemmed | A systematic review of the clinical characteristics and course of atrioventricular blocks in hyperthyroidism |
| title_short | A systematic review of the clinical characteristics and course of atrioventricular blocks in hyperthyroidism |
| title_sort | A systematic review of the clinical characteristics and course of atrioventricular blocks in hyperthyroidism |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Medical biochemistry and metabolomics Hyperthyroidism Grave’s disease multinodular goitre thyroid heart block AV block atrioventricular blocks |