Post-Thymectomy Autoimmune Flare-Up With New-Onset Type 1 Diabetes Mellitus
<div><p>The thymus gland aids in the maturation of the immune system. An overactive or malfunctioning thymus gland, as seen in thymomas, can lead to disrupted immune systems. Thymectomy, the usual treatment, can paradoxically lead to further derangements in the immune system, leading to...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , |
| منشور في: |
2024
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513544598323200 |
|---|---|
| author | Tareq Al-Bkoor (21767192) |
| author2 | Fateen Ata (12217764) Ammara Bint I Bilal (14777176) Mohammed Abdulgayoom (14777791) Honar Cherif (17746722) Haval Surchi (20451660) |
| author2_role | author author author author author |
| author_facet | Tareq Al-Bkoor (21767192) Fateen Ata (12217764) Ammara Bint I Bilal (14777176) Mohammed Abdulgayoom (14777791) Honar Cherif (17746722) Haval Surchi (20451660) |
| author_role | author |
| dc.creator.none.fl_str_mv | Tareq Al-Bkoor (21767192) Fateen Ata (12217764) Ammara Bint I Bilal (14777176) Mohammed Abdulgayoom (14777791) Honar Cherif (17746722) Haval Surchi (20451660) |
| dc.date.none.fl_str_mv | 2024-03-22T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1210/jcemcr/luae039 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Post-Thymectomy_Autoimmune_Flare-Up_With_New-Onset_Type_1_Diabetes_Mellitus/29624690 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Medical biochemistry and metabolomics Oncology and carcinogenesis thymectomy type 1 diabetes diabetes mellitus autoimmune diabetes post-thymectomy autoimmune flare |
| dc.title.none.fl_str_mv | Post-Thymectomy Autoimmune Flare-Up With New-Onset Type 1 Diabetes Mellitus |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>The thymus gland aids in the maturation of the immune system. An overactive or malfunctioning thymus gland, as seen in thymomas, can lead to disrupted immune systems. Thymectomy, the usual treatment, can paradoxically lead to further derangements in the immune system, leading to new autoimmune disorders. Most of these reported disorders are rheumatological. Except preclinical studies, there are no reported cases of autoimmune diabetes post-thymectomy. A 25-year-old woman who had malignant thymoma underwent chemotherapy, followed by thymectomy and radiotherapy. She developed autoimmune diabetes mellitus (AID) approximately 1 year post-thymectomy, evident from raised glycated hemoglobin, anti-glutamic acid decarboxylase (GAD) antibodies, ineffectiveness of oral glucose-lowering agents, and positive response to insulin. AID can occur after thymectomy, as evidenced by animal studies and this case report. Whether these patients would have long-term outcomes and control of diabetes differently than classic type 1 diabetes mellitus (T1D) is uncertain. Further research is needed to prove causality between thymectomy and diabetes.</p><p> </p></div><h2>Other Information</h2> <p> Published in: JCEM Case Reports<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1210/jcemcr/luae039" target="_blank">https://dx.doi.org/10.1210/jcemcr/luae039</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_be40dc47a8a6339edbd213686ec276af |
| identifier_str_mv | 10.1210/jcemcr/luae039 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29624690 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Post-Thymectomy Autoimmune Flare-Up With New-Onset Type 1 Diabetes MellitusTareq Al-Bkoor (21767192)Fateen Ata (12217764)Ammara Bint I Bilal (14777176)Mohammed Abdulgayoom (14777791)Honar Cherif (17746722)Haval Surchi (20451660)Biomedical and clinical sciencesImmunologyMedical biochemistry and metabolomicsOncology and carcinogenesisthymectomytype 1 diabetesdiabetes mellitusautoimmune diabetespost-thymectomy autoimmune flare<div><p>The thymus gland aids in the maturation of the immune system. An overactive or malfunctioning thymus gland, as seen in thymomas, can lead to disrupted immune systems. Thymectomy, the usual treatment, can paradoxically lead to further derangements in the immune system, leading to new autoimmune disorders. Most of these reported disorders are rheumatological. Except preclinical studies, there are no reported cases of autoimmune diabetes post-thymectomy. A 25-year-old woman who had malignant thymoma underwent chemotherapy, followed by thymectomy and radiotherapy. She developed autoimmune diabetes mellitus (AID) approximately 1 year post-thymectomy, evident from raised glycated hemoglobin, anti-glutamic acid decarboxylase (GAD) antibodies, ineffectiveness of oral glucose-lowering agents, and positive response to insulin. AID can occur after thymectomy, as evidenced by animal studies and this case report. Whether these patients would have long-term outcomes and control of diabetes differently than classic type 1 diabetes mellitus (T1D) is uncertain. Further research is needed to prove causality between thymectomy and diabetes.</p><p> </p></div><h2>Other Information</h2> <p> Published in: JCEM Case Reports<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1210/jcemcr/luae039" target="_blank">https://dx.doi.org/10.1210/jcemcr/luae039</a></p>2024-03-22T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1210/jcemcr/luae039https://figshare.com/articles/journal_contribution/Post-Thymectomy_Autoimmune_Flare-Up_With_New-Onset_Type_1_Diabetes_Mellitus/29624690CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/296246902024-03-22T09:00:00Z |
| spellingShingle | Post-Thymectomy Autoimmune Flare-Up With New-Onset Type 1 Diabetes Mellitus Tareq Al-Bkoor (21767192) Biomedical and clinical sciences Immunology Medical biochemistry and metabolomics Oncology and carcinogenesis thymectomy type 1 diabetes diabetes mellitus autoimmune diabetes post-thymectomy autoimmune flare |
| status_str | publishedVersion |
| title | Post-Thymectomy Autoimmune Flare-Up With New-Onset Type 1 Diabetes Mellitus |
| title_full | Post-Thymectomy Autoimmune Flare-Up With New-Onset Type 1 Diabetes Mellitus |
| title_fullStr | Post-Thymectomy Autoimmune Flare-Up With New-Onset Type 1 Diabetes Mellitus |
| title_full_unstemmed | Post-Thymectomy Autoimmune Flare-Up With New-Onset Type 1 Diabetes Mellitus |
| title_short | Post-Thymectomy Autoimmune Flare-Up With New-Onset Type 1 Diabetes Mellitus |
| title_sort | Post-Thymectomy Autoimmune Flare-Up With New-Onset Type 1 Diabetes Mellitus |
| topic | Biomedical and clinical sciences Immunology Medical biochemistry and metabolomics Oncology and carcinogenesis thymectomy type 1 diabetes diabetes mellitus autoimmune diabetes post-thymectomy autoimmune flare |