Natural resorcylic acid lactones: A chemical biology approach for anticancer activity
<p dir="ltr">Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including anticancer activities. Following discovery of th...
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2022
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إضافة وسم
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| _version_ | 1864513551476981760 |
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| author | Shilpa Kuttikrishnan (3520079) |
| author2 | Kirti S. Prabhu (4246144) Ahmed H. Al Sharie (9650242) Yazan O. Al Zu'bi (17191321) Feras Q. Alali (2691907) Nicholas H. Oberlies (326437) Aamir Ahmad (233201) Tamam El-Elimat (694398) Shahab Uddin (154400) |
| author2_role | author author author author author author author author |
| author_facet | Shilpa Kuttikrishnan (3520079) Kirti S. Prabhu (4246144) Ahmed H. Al Sharie (9650242) Yazan O. Al Zu'bi (17191321) Feras Q. Alali (2691907) Nicholas H. Oberlies (326437) Aamir Ahmad (233201) Tamam El-Elimat (694398) Shahab Uddin (154400) |
| author_role | author |
| dc.creator.none.fl_str_mv | Shilpa Kuttikrishnan (3520079) Kirti S. Prabhu (4246144) Ahmed H. Al Sharie (9650242) Yazan O. Al Zu'bi (17191321) Feras Q. Alali (2691907) Nicholas H. Oberlies (326437) Aamir Ahmad (233201) Tamam El-Elimat (694398) Shahab Uddin (154400) |
| dc.date.none.fl_str_mv | 2022-02-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.drudis.2021.10.001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Natural_resorcylic_acid_lactones_A_chemical_biology_approach_for_anticancer_activity/24339448 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Resorcylic acid lactones Heat shock protein 90 inhibitors Protein kinase inhibitors Radicicol Hypothemycin 5Z-7-oxo-zeaenol |
| dc.title.none.fl_str_mv | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including anticancer activities. Following discovery of the selective Hsp90 inhibition activity of radicicol, the kinase inhibition activity of hypothemycin, monocillin II, 5Z-7-oxo-zeaenol, and L-783,277 RALs, and the nuclear factor kappa B (NF-κB) inhibition activity of the RAL zearalenone, have attracted great attention as potential therapeutics for cancer treatment. In this minireview, we focus on natural RALs that possess cytotoxic activities [IC50 values < 10 μM (or 4–5 μg/ml)], discussing their structures, isolation, occurrence, biological activities, and anticancer molecular mechanisms.</p><h2>Other Information</h2><p dir="ltr">Published in: Drug Discovery Today<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.drudis.2021.10.001" target="_blank">https://dx.doi.org/10.1016/j.drudis.2021.10.001</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_be5f63ac0d9ec219d97a459a9f13c62b |
| identifier_str_mv | 10.1016/j.drudis.2021.10.001 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24339448 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Natural resorcylic acid lactones: A chemical biology approach for anticancer activityShilpa Kuttikrishnan (3520079)Kirti S. Prabhu (4246144)Ahmed H. Al Sharie (9650242)Yazan O. Al Zu'bi (17191321)Feras Q. Alali (2691907)Nicholas H. Oberlies (326437)Aamir Ahmad (233201)Tamam El-Elimat (694398)Shahab Uddin (154400)Biomedical and clinical sciencesMedical biochemistry and metabolomicsOncology and carcinogenesisPharmacology and pharmaceutical sciencesResorcylic acid lactonesHeat shock protein 90 inhibitorsProtein kinase inhibitorsRadicicolHypothemycin5Z-7-oxo-zeaenol<p dir="ltr">Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including anticancer activities. Following discovery of the selective Hsp90 inhibition activity of radicicol, the kinase inhibition activity of hypothemycin, monocillin II, 5Z-7-oxo-zeaenol, and L-783,277 RALs, and the nuclear factor kappa B (NF-κB) inhibition activity of the RAL zearalenone, have attracted great attention as potential therapeutics for cancer treatment. In this minireview, we focus on natural RALs that possess cytotoxic activities [IC50 values < 10 μM (or 4–5 μg/ml)], discussing their structures, isolation, occurrence, biological activities, and anticancer molecular mechanisms.</p><h2>Other Information</h2><p dir="ltr">Published in: Drug Discovery Today<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.drudis.2021.10.001" target="_blank">https://dx.doi.org/10.1016/j.drudis.2021.10.001</a></p>2022-02-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.drudis.2021.10.001https://figshare.com/articles/journal_contribution/Natural_resorcylic_acid_lactones_A_chemical_biology_approach_for_anticancer_activity/24339448CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/243394482022-02-01T00:00:00Z |
| spellingShingle | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity Shilpa Kuttikrishnan (3520079) Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Resorcylic acid lactones Heat shock protein 90 inhibitors Protein kinase inhibitors Radicicol Hypothemycin 5Z-7-oxo-zeaenol |
| status_str | publishedVersion |
| title | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity |
| title_full | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity |
| title_fullStr | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity |
| title_full_unstemmed | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity |
| title_short | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity |
| title_sort | Natural resorcylic acid lactones: A chemical biology approach for anticancer activity |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Resorcylic acid lactones Heat shock protein 90 inhibitors Protein kinase inhibitors Radicicol Hypothemycin 5Z-7-oxo-zeaenol |