Tamsulosin plus Tadalafil compared with Tamsulosin alone for benign prostate hyperplasia in patients with or without erectile dysfunction: a meta-analysis and meta-regression of randomized controlled trials
<h3>Background</h3><p dir="ltr">Combination pharmacotherapy with tamsulosin plus tadalafil could be a superior strategy compared to conventional monotherapy with tamsulosin in patients with Benign prostatic obstruction (BPO) with or without erectile dysfunction.</p>...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2025
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| الموضوعات: | |
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| _version_ | 1864513534111514624 |
|---|---|
| author | Tallal Mushtaq Hashmi (22330558) |
| author2 | Rohma Zia (22501958) Hadiah Ashraf (22501961) Momina Siddiqui (22501964) Ali Haider (1483597) Valencia Rumampouw (22501967) Momina Aslam Khan (22501970) Mushood Ahmed (19231379) Javed Iqbal (2121922) |
| author2_role | author author author author author author author author |
| author_facet | Tallal Mushtaq Hashmi (22330558) Rohma Zia (22501958) Hadiah Ashraf (22501961) Momina Siddiqui (22501964) Ali Haider (1483597) Valencia Rumampouw (22501967) Momina Aslam Khan (22501970) Mushood Ahmed (19231379) Javed Iqbal (2121922) |
| author_role | author |
| dc.creator.none.fl_str_mv | Tallal Mushtaq Hashmi (22330558) Rohma Zia (22501958) Hadiah Ashraf (22501961) Momina Siddiqui (22501964) Ali Haider (1483597) Valencia Rumampouw (22501967) Momina Aslam Khan (22501970) Mushood Ahmed (19231379) Javed Iqbal (2121922) |
| dc.date.none.fl_str_mv | 2025-05-11T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s00345-025-05662-w |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Tamsulosin_plus_Tadalafil_compared_with_Tamsulosin_alone_for_benign_prostate_hyperplasia_in_patients_with_or_without_erectile_dysfunction_a_meta-analysis_and_meta-regression_of_randomized_controlled_trials/30454388 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Reproductive medicine Health sciences Epidemiology Benign prostatic hyperplasia Erectile dysfunction Tamsulosin Tadalafil Meta-analysis |
| dc.title.none.fl_str_mv | Tamsulosin plus Tadalafil compared with Tamsulosin alone for benign prostate hyperplasia in patients with or without erectile dysfunction: a meta-analysis and meta-regression of randomized controlled trials |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Combination pharmacotherapy with tamsulosin plus tadalafil could be a superior strategy compared to conventional monotherapy with tamsulosin in patients with Benign prostatic obstruction (BPO) with or without erectile dysfunction.</p><h3>Methodology</h3><p dir="ltr">A comprehensive search was conducted across PubMed, the Cochrane Library, and Embase to identify studies assessing the efficacy and safety of combination therapy compared with monotherapy in patients with BPO with or without erectile dysfunction. A random effects meta-analysis was performed with R version 4.4.1 using the 'meta' package.</p><h3>Results</h3><p dir="ltr">We included eleven RCTs, with a combined total of 940 patients. Our analysis demonstrated that the combination therapy is associated with a greater reduction in overall IPSS (MD = − 2.78, 95% CI − 3.97 to − 1.59; P < 0.01), IIEF (MD = 2.98, 95% CI 1.64 to 4.33; P < 0.01), QoL score (MD = − 0.58, 95% CI − 0.86 to − 0.30; P < 0.01), PVR (MD = − 9.34, 95% CI = -15.52 to − 3.16; P < 0.01) and a significant improvement in Qmax (MD = 1.04, 95% CI 0.43 to 1.64; P < 0.01) as compared to tamsulosin alone. However, combination therapy resulted in a higher incidence of pain (OR = 5.66, 95% CI 2.56 to 12.52; P < 0.01) and other adverse events (OR = 2.97, 95% CI 1.60 to 5.49; P < 0.01).</p><h3>Conclusion</h3><p dir="ltr">Combination therapy with tamsulosin and tadalafil demonstrated superior efficacy over tamsulosin monotherapy in reducing LUTS, improving quality of life, and enhancing erectile function. However, it was associated with a higher incidence of adverse effects.</p><h2>Other Information</h2><p dir="ltr">Published in: World Journal of Urology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00345-025-05662-w" target="_blank">https://dx.doi.org/10.1007/s00345-025-05662-w</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_be6de0c17518b17bd262780355ca3edb |
| identifier_str_mv | 10.1007/s00345-025-05662-w |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30454388 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Tamsulosin plus Tadalafil compared with Tamsulosin alone for benign prostate hyperplasia in patients with or without erectile dysfunction: a meta-analysis and meta-regression of randomized controlled trialsTallal Mushtaq Hashmi (22330558)Rohma Zia (22501958)Hadiah Ashraf (22501961)Momina Siddiqui (22501964)Ali Haider (1483597)Valencia Rumampouw (22501967)Momina Aslam Khan (22501970)Mushood Ahmed (19231379)Javed Iqbal (2121922)Biomedical and clinical sciencesClinical sciencesPharmacology and pharmaceutical sciencesReproductive medicineHealth sciencesEpidemiologyBenign prostatic hyperplasiaErectile dysfunctionTamsulosinTadalafilMeta-analysis<h3>Background</h3><p dir="ltr">Combination pharmacotherapy with tamsulosin plus tadalafil could be a superior strategy compared to conventional monotherapy with tamsulosin in patients with Benign prostatic obstruction (BPO) with or without erectile dysfunction.</p><h3>Methodology</h3><p dir="ltr">A comprehensive search was conducted across PubMed, the Cochrane Library, and Embase to identify studies assessing the efficacy and safety of combination therapy compared with monotherapy in patients with BPO with or without erectile dysfunction. A random effects meta-analysis was performed with R version 4.4.1 using the 'meta' package.</p><h3>Results</h3><p dir="ltr">We included eleven RCTs, with a combined total of 940 patients. Our analysis demonstrated that the combination therapy is associated with a greater reduction in overall IPSS (MD = − 2.78, 95% CI − 3.97 to − 1.59; P < 0.01), IIEF (MD = 2.98, 95% CI 1.64 to 4.33; P < 0.01), QoL score (MD = − 0.58, 95% CI − 0.86 to − 0.30; P < 0.01), PVR (MD = − 9.34, 95% CI = -15.52 to − 3.16; P < 0.01) and a significant improvement in Qmax (MD = 1.04, 95% CI 0.43 to 1.64; P < 0.01) as compared to tamsulosin alone. However, combination therapy resulted in a higher incidence of pain (OR = 5.66, 95% CI 2.56 to 12.52; P < 0.01) and other adverse events (OR = 2.97, 95% CI 1.60 to 5.49; P < 0.01).</p><h3>Conclusion</h3><p dir="ltr">Combination therapy with tamsulosin and tadalafil demonstrated superior efficacy over tamsulosin monotherapy in reducing LUTS, improving quality of life, and enhancing erectile function. However, it was associated with a higher incidence of adverse effects.</p><h2>Other Information</h2><p dir="ltr">Published in: World Journal of Urology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00345-025-05662-w" target="_blank">https://dx.doi.org/10.1007/s00345-025-05662-w</a></p>2025-05-11T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s00345-025-05662-whttps://figshare.com/articles/journal_contribution/Tamsulosin_plus_Tadalafil_compared_with_Tamsulosin_alone_for_benign_prostate_hyperplasia_in_patients_with_or_without_erectile_dysfunction_a_meta-analysis_and_meta-regression_of_randomized_controlled_trials/30454388CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/304543882025-05-11T09:00:00Z |
| spellingShingle | Tamsulosin plus Tadalafil compared with Tamsulosin alone for benign prostate hyperplasia in patients with or without erectile dysfunction: a meta-analysis and meta-regression of randomized controlled trials Tallal Mushtaq Hashmi (22330558) Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Reproductive medicine Health sciences Epidemiology Benign prostatic hyperplasia Erectile dysfunction Tamsulosin Tadalafil Meta-analysis |
| status_str | publishedVersion |
| title | Tamsulosin plus Tadalafil compared with Tamsulosin alone for benign prostate hyperplasia in patients with or without erectile dysfunction: a meta-analysis and meta-regression of randomized controlled trials |
| title_full | Tamsulosin plus Tadalafil compared with Tamsulosin alone for benign prostate hyperplasia in patients with or without erectile dysfunction: a meta-analysis and meta-regression of randomized controlled trials |
| title_fullStr | Tamsulosin plus Tadalafil compared with Tamsulosin alone for benign prostate hyperplasia in patients with or without erectile dysfunction: a meta-analysis and meta-regression of randomized controlled trials |
| title_full_unstemmed | Tamsulosin plus Tadalafil compared with Tamsulosin alone for benign prostate hyperplasia in patients with or without erectile dysfunction: a meta-analysis and meta-regression of randomized controlled trials |
| title_short | Tamsulosin plus Tadalafil compared with Tamsulosin alone for benign prostate hyperplasia in patients with or without erectile dysfunction: a meta-analysis and meta-regression of randomized controlled trials |
| title_sort | Tamsulosin plus Tadalafil compared with Tamsulosin alone for benign prostate hyperplasia in patients with or without erectile dysfunction: a meta-analysis and meta-regression of randomized controlled trials |
| topic | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Reproductive medicine Health sciences Epidemiology Benign prostatic hyperplasia Erectile dysfunction Tamsulosin Tadalafil Meta-analysis |