Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease
<h3>Background and aim</h3><p dir="ltr">Toxic oligomeric α-synuclein (αS; O-αS) has been suggested to play a central role in the pathogenesis of Lewy body diseases such as Parkinson’s disease (PD). Cerebrospinal fluid (CSF) levels of αS, O-αS, total and phosphorylated tau...
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2019
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| _version_ | 1864513513947398144 |
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| author | Hidetomo Murakami (6105284) |
| author2 | Takahiko Tokuda (105837) Omar M. A. El-Agnaf (8809331) Takuma Ohmichi (718120) Ayako Miki (6105290) Hideaki Ohashi (6800840) Yoshiyuki Owan (6105299) Yu Saito (1408612) Satoshi Yano (6105302) Tamao Tsukie (6800843) Takeshi Ikeuchi (397119) Kenjiro Ono (419133) |
| author2_role | author author author author author author author author author author author |
| author_facet | Hidetomo Murakami (6105284) Takahiko Tokuda (105837) Omar M. A. El-Agnaf (8809331) Takuma Ohmichi (718120) Ayako Miki (6105290) Hideaki Ohashi (6800840) Yoshiyuki Owan (6105299) Yu Saito (1408612) Satoshi Yano (6105302) Tamao Tsukie (6800843) Takeshi Ikeuchi (397119) Kenjiro Ono (419133) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hidetomo Murakami (6105284) Takahiko Tokuda (105837) Omar M. A. El-Agnaf (8809331) Takuma Ohmichi (718120) Ayako Miki (6105290) Hideaki Ohashi (6800840) Yoshiyuki Owan (6105299) Yu Saito (1408612) Satoshi Yano (6105302) Tamao Tsukie (6800843) Takeshi Ikeuchi (397119) Kenjiro Ono (419133) |
| dc.date.none.fl_str_mv | 2019-06-04T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12883-019-1346-y |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Correlated_levels_of_cerebrospinal_fluid_pathogenic_proteins_in_drug-na_ve_Parkinson_s_disease/25907584 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences Parkinson’s disease α-Synuclein Oligomer Amyloid β-protein (1–42) Tau protein Clinical symptom |
| dc.title.none.fl_str_mv | Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background and aim</h3><p dir="ltr">Toxic oligomeric α-synuclein (αS; O-αS) has been suggested to play a central role in the pathogenesis of Lewy body diseases such as Parkinson’s disease (PD). Cerebrospinal fluid (CSF) levels of αS, O-αS, total and phosphorylated tau, and amyloid β 1–42 (Aβ1–42) are thought to reflect the pathophysiology or clinical symptoms in PD. In this study, we examined correlations of the CSF levels of these proteins with the clinical symptoms, and with each other in drug-naïve patients with PD.</p><p><br></p><h3>Methods</h3><p dir="ltr">Twenty-seven drug-naïve patients with PD were included. Motor and cognitive functions were assessed using the Unified Parkinson’s Disease Rating Scale (UPDRS), Montreal Cognitive Assessment (MoCA), and Neurobehavioral Cognitive Status Examination (COGNISTAT). CSF levels of total αS, O-αS, Aβ1–42, total tau and tau phosphorylated at threonine 181 (P-tau181p) were measured. CSF levels of these proteins were compared with clinical assessments from the UPDRS, MoCA and COGNISTAT using Spearman correlation analysis. Spearman correlation coefficients among CSF protein levels were also evaluated.</p><p><br></p><h3>Results</h3><p dir="ltr">CSF levels of αS were negatively correlated with UPDRS part III (motor score) (p < 0.05) and bradykinesia (p < 0.01), and positively correlated with COGNISTAT subtest of judgement (p < 0.01) and CSF levels of Aβ1–42 (p < 0.001), total tau (p < 0.001) and P-tau181p (p < 0.01). Lower CSF levels of Aβ1–42, total tau and P-tau181p were significantly related to worsening of some motor and/or cognitive functions. The CSF level of O-αS showed no correlation with any motor and cognitive assessments or with CSF levels of the other proteins.</p><p><br></p><h3>Conclusion</h3><p dir="ltr">CSF levels of αS are correlated with some clinical symptoms and CSF levels of other pathogenic proteins in drug-naïve PD patients. These correlations suggest a central role for interaction and aggregation of αS with Aβ1–42, tau, and phosphorylated tau in the pathogenesis of PD. Although O-αS has been shown to have neurotoxic effects, CSF levels do not reflect clinical symptoms or levels of other proteins in cross-sectional assessment.</p><h2>Other Information</h2><p dir="ltr">Published in: BMC Neurology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12883-019-1346-y" target="_blank">https://dx.doi.org/10.1186/s12883-019-1346-y</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_becca354ff188847a79b7388c87706f4 |
| identifier_str_mv | 10.1186/s12883-019-1346-y |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25907584 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s diseaseHidetomo Murakami (6105284)Takahiko Tokuda (105837)Omar M. A. El-Agnaf (8809331)Takuma Ohmichi (718120)Ayako Miki (6105290)Hideaki Ohashi (6800840)Yoshiyuki Owan (6105299)Yu Saito (1408612)Satoshi Yano (6105302)Tamao Tsukie (6800843)Takeshi Ikeuchi (397119)Kenjiro Ono (419133)Biomedical and clinical sciencesNeurosciencesParkinson’s diseaseα-SynucleinOligomerAmyloid β-protein (1–42)Tau proteinClinical symptom<h3>Background and aim</h3><p dir="ltr">Toxic oligomeric α-synuclein (αS; O-αS) has been suggested to play a central role in the pathogenesis of Lewy body diseases such as Parkinson’s disease (PD). Cerebrospinal fluid (CSF) levels of αS, O-αS, total and phosphorylated tau, and amyloid β 1–42 (Aβ1–42) are thought to reflect the pathophysiology or clinical symptoms in PD. In this study, we examined correlations of the CSF levels of these proteins with the clinical symptoms, and with each other in drug-naïve patients with PD.</p><p><br></p><h3>Methods</h3><p dir="ltr">Twenty-seven drug-naïve patients with PD were included. Motor and cognitive functions were assessed using the Unified Parkinson’s Disease Rating Scale (UPDRS), Montreal Cognitive Assessment (MoCA), and Neurobehavioral Cognitive Status Examination (COGNISTAT). CSF levels of total αS, O-αS, Aβ1–42, total tau and tau phosphorylated at threonine 181 (P-tau181p) were measured. CSF levels of these proteins were compared with clinical assessments from the UPDRS, MoCA and COGNISTAT using Spearman correlation analysis. Spearman correlation coefficients among CSF protein levels were also evaluated.</p><p><br></p><h3>Results</h3><p dir="ltr">CSF levels of αS were negatively correlated with UPDRS part III (motor score) (p < 0.05) and bradykinesia (p < 0.01), and positively correlated with COGNISTAT subtest of judgement (p < 0.01) and CSF levels of Aβ1–42 (p < 0.001), total tau (p < 0.001) and P-tau181p (p < 0.01). Lower CSF levels of Aβ1–42, total tau and P-tau181p were significantly related to worsening of some motor and/or cognitive functions. The CSF level of O-αS showed no correlation with any motor and cognitive assessments or with CSF levels of the other proteins.</p><p><br></p><h3>Conclusion</h3><p dir="ltr">CSF levels of αS are correlated with some clinical symptoms and CSF levels of other pathogenic proteins in drug-naïve PD patients. These correlations suggest a central role for interaction and aggregation of αS with Aβ1–42, tau, and phosphorylated tau in the pathogenesis of PD. Although O-αS has been shown to have neurotoxic effects, CSF levels do not reflect clinical symptoms or levels of other proteins in cross-sectional assessment.</p><h2>Other Information</h2><p dir="ltr">Published in: BMC Neurology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12883-019-1346-y" target="_blank">https://dx.doi.org/10.1186/s12883-019-1346-y</a></p>2019-06-04T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12883-019-1346-yhttps://figshare.com/articles/journal_contribution/Correlated_levels_of_cerebrospinal_fluid_pathogenic_proteins_in_drug-na_ve_Parkinson_s_disease/25907584CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/259075842019-06-04T03:00:00Z |
| spellingShingle | Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease Hidetomo Murakami (6105284) Biomedical and clinical sciences Neurosciences Parkinson’s disease α-Synuclein Oligomer Amyloid β-protein (1–42) Tau protein Clinical symptom |
| status_str | publishedVersion |
| title | Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease |
| title_full | Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease |
| title_fullStr | Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease |
| title_full_unstemmed | Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease |
| title_short | Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease |
| title_sort | Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease |
| topic | Biomedical and clinical sciences Neurosciences Parkinson’s disease α-Synuclein Oligomer Amyloid β-protein (1–42) Tau protein Clinical symptom |