Prenatal psychological distress and 11β-HSD2 gene expression in human placentas: Systematic review and meta-analysis
<h3>Background</h3><p dir="ltr">The placenta acts as a buffer to regulate the degree of fetal exposure to maternal cortisol through the 11-Beta Hydroxysteroid Dehydrogenase isoenzyme type 2 (<i>11-β HSD2</i>) enzyme. We conducted a systematic review and meta-a...
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2024
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513556000538624 |
|---|---|
| author | Angham Ibrahim Tartour (19756953) |
| author2 | Tawanda Chivese (801864) Safa Eltayeb (19756956) Fatima M. Elamin (19756959) Eleni Fthenou (216980) Mohammed Seed Ahmed (798933) Giridhara Rathnaiah Babu (17933762) |
| author2_role | author author author author author author |
| author_facet | Angham Ibrahim Tartour (19756953) Tawanda Chivese (801864) Safa Eltayeb (19756956) Fatima M. Elamin (19756959) Eleni Fthenou (216980) Mohammed Seed Ahmed (798933) Giridhara Rathnaiah Babu (17933762) |
| author_role | author |
| dc.creator.none.fl_str_mv | Angham Ibrahim Tartour (19756953) Tawanda Chivese (801864) Safa Eltayeb (19756956) Fatima M. Elamin (19756959) Eleni Fthenou (216980) Mohammed Seed Ahmed (798933) Giridhara Rathnaiah Babu (17933762) |
| dc.date.none.fl_str_mv | 2024-08-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.psyneuen.2024.107060 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Prenatal_psychological_distress_and_11_-HSD2_gene_expression_in_human_placentas_Systematic_review_and_meta-analysis/27130053 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Neurosciences Reproductive medicine Health sciences Public health Prenatal psychological distress 11β-Hydroxysteroid Dehydrogenase Type 2 Gene expression Fetal reprogramming Placenta Early-life exposures |
| dc.title.none.fl_str_mv | Prenatal psychological distress and 11β-HSD2 gene expression in human placentas: Systematic review and meta-analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">The placenta acts as a buffer to regulate the degree of fetal exposure to maternal cortisol through the 11-Beta Hydroxysteroid Dehydrogenase isoenzyme type 2 (<i>11-β HSD2</i>) enzyme. We conducted a systematic review and meta-analysis to assess the effect of prenatal psychological distress (PPD) on placental <i>11-β HSD2</i> gene expression and explore the related mechanistic pathways involved in fetal neurodevelopment.</p><h3>Methods</h3><p dir="ltr">We searched PubMed, Embase, Scopus, APA PsycInfo®, and ProQuest Dissertations for observational studies assessing the association between PPD and <i>11-β HSD2</i> expression in human placentas. Adjusted regression coefficients (β) and corresponding 95% confidence intervals (CIs) were pooled based on three contextual PPD exposure groups: prenatal depression, anxiety symptoms, and perceived stress.</p><h3>Results</h3><p dir="ltr">Of 3159 retrieved records, sixteen longitudinal studies involving 1869 participants across seven countries were included. Overall, exposure to PPD disorders showed weak negative associations with the placental <i>11-β HSD2</i> gene expression as follows: prenatal depression (β −0.01, 95% CI 0.05–0.02, I2=0%), anxiety symptoms (β −0.02, 95% CI 0.06–0.01, I2=0%), and perceived stress (β −0.01 95% CI 0.06–0.04, I2=62.8%). Third-trimester PPD exposure was more frequently associated with lower placental <i>11-β HSD2</i> levels. PPD and placental <i>11-β HSD2</i> were associated with changes in cortisol reactivity and the development of adverse health outcomes in mothers and children. Female-offspring were more vulnerable to PPD exposures.</p><h3>Conclusion</h3><p dir="ltr">The study presents evidence of a modest role of prenatal psychological distress in regulating placental 11-β HSD2 gene expression. Future prospective cohorts utilizing larger sample sizes or advanced statistical methods to enhance the detection of small effect sizes should be planned. Additionally, controlling for key predictors such as the mother’s ethnicity, trimester of PPD exposure, mode of delivery, and infant sex is crucial for valid exploration of PPD effects on fetal programming.</p><h2>Other Information</h2><p dir="ltr">Published in: Psychoneuroendocrinology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.psyneuen.2024.107060" target="_blank">https://dx.doi.org/10.1016/j.psyneuen.2024.107060</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_bf345cccc27a624f94087ddc59c990b4 |
| identifier_str_mv | 10.1016/j.psyneuen.2024.107060 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27130053 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Prenatal psychological distress and 11β-HSD2 gene expression in human placentas: Systematic review and meta-analysisAngham Ibrahim Tartour (19756953)Tawanda Chivese (801864)Safa Eltayeb (19756956)Fatima M. Elamin (19756959)Eleni Fthenou (216980)Mohammed Seed Ahmed (798933)Giridhara Rathnaiah Babu (17933762)Biological sciencesGeneticsBiomedical and clinical sciencesClinical sciencesNeurosciencesReproductive medicineHealth sciencesPublic healthPrenatal psychological distress11β-Hydroxysteroid Dehydrogenase Type 2Gene expressionFetal reprogrammingPlacentaEarly-life exposures<h3>Background</h3><p dir="ltr">The placenta acts as a buffer to regulate the degree of fetal exposure to maternal cortisol through the 11-Beta Hydroxysteroid Dehydrogenase isoenzyme type 2 (<i>11-β HSD2</i>) enzyme. We conducted a systematic review and meta-analysis to assess the effect of prenatal psychological distress (PPD) on placental <i>11-β HSD2</i> gene expression and explore the related mechanistic pathways involved in fetal neurodevelopment.</p><h3>Methods</h3><p dir="ltr">We searched PubMed, Embase, Scopus, APA PsycInfo®, and ProQuest Dissertations for observational studies assessing the association between PPD and <i>11-β HSD2</i> expression in human placentas. Adjusted regression coefficients (β) and corresponding 95% confidence intervals (CIs) were pooled based on three contextual PPD exposure groups: prenatal depression, anxiety symptoms, and perceived stress.</p><h3>Results</h3><p dir="ltr">Of 3159 retrieved records, sixteen longitudinal studies involving 1869 participants across seven countries were included. Overall, exposure to PPD disorders showed weak negative associations with the placental <i>11-β HSD2</i> gene expression as follows: prenatal depression (β −0.01, 95% CI 0.05–0.02, I2=0%), anxiety symptoms (β −0.02, 95% CI 0.06–0.01, I2=0%), and perceived stress (β −0.01 95% CI 0.06–0.04, I2=62.8%). Third-trimester PPD exposure was more frequently associated with lower placental <i>11-β HSD2</i> levels. PPD and placental <i>11-β HSD2</i> were associated with changes in cortisol reactivity and the development of adverse health outcomes in mothers and children. Female-offspring were more vulnerable to PPD exposures.</p><h3>Conclusion</h3><p dir="ltr">The study presents evidence of a modest role of prenatal psychological distress in regulating placental 11-β HSD2 gene expression. Future prospective cohorts utilizing larger sample sizes or advanced statistical methods to enhance the detection of small effect sizes should be planned. Additionally, controlling for key predictors such as the mother’s ethnicity, trimester of PPD exposure, mode of delivery, and infant sex is crucial for valid exploration of PPD effects on fetal programming.</p><h2>Other Information</h2><p dir="ltr">Published in: Psychoneuroendocrinology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.psyneuen.2024.107060" target="_blank">https://dx.doi.org/10.1016/j.psyneuen.2024.107060</a></p>2024-08-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.psyneuen.2024.107060https://figshare.com/articles/journal_contribution/Prenatal_psychological_distress_and_11_-HSD2_gene_expression_in_human_placentas_Systematic_review_and_meta-analysis/27130053CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/271300532024-08-01T00:00:00Z |
| spellingShingle | Prenatal psychological distress and 11β-HSD2 gene expression in human placentas: Systematic review and meta-analysis Angham Ibrahim Tartour (19756953) Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Neurosciences Reproductive medicine Health sciences Public health Prenatal psychological distress 11β-Hydroxysteroid Dehydrogenase Type 2 Gene expression Fetal reprogramming Placenta Early-life exposures |
| status_str | publishedVersion |
| title | Prenatal psychological distress and 11β-HSD2 gene expression in human placentas: Systematic review and meta-analysis |
| title_full | Prenatal psychological distress and 11β-HSD2 gene expression in human placentas: Systematic review and meta-analysis |
| title_fullStr | Prenatal psychological distress and 11β-HSD2 gene expression in human placentas: Systematic review and meta-analysis |
| title_full_unstemmed | Prenatal psychological distress and 11β-HSD2 gene expression in human placentas: Systematic review and meta-analysis |
| title_short | Prenatal psychological distress and 11β-HSD2 gene expression in human placentas: Systematic review and meta-analysis |
| title_sort | Prenatal psychological distress and 11β-HSD2 gene expression in human placentas: Systematic review and meta-analysis |
| topic | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Neurosciences Reproductive medicine Health sciences Public health Prenatal psychological distress 11β-Hydroxysteroid Dehydrogenase Type 2 Gene expression Fetal reprogramming Placenta Early-life exposures |