COVID-19 Severity in Patients With Apical Periodontitis: A Case Control Study
<h3>Objectives</h3><p dir="ltr">Apical <u>periodontitis </u>(AP) has been associated with systemic inflammatory biomarkers that have also been associated with COVID-19 severity. This study was designed to test the hypothesis that the presence of apical periodo...
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2024
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| _version_ | 1864513545507438592 |
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| author | Nadya Marouf (14150724) |
| author2 | Raidan Ba-Hattab (17773230) Fatima Al-Sheeb (21633377) Amal Diab (21633380) Hanan Diab (14779462) Maryam Al-Majed (21633383) Khalid Al-Haithami (21633386) Ghanim Al-Mannai (21633389) Noha Barhom (14150748) Shailaja Tharupeedikayil (21633392) Faleh Tamimi (2867255) |
| author2_role | author author author author author author author author author author |
| author_facet | Nadya Marouf (14150724) Raidan Ba-Hattab (17773230) Fatima Al-Sheeb (21633377) Amal Diab (21633380) Hanan Diab (14779462) Maryam Al-Majed (21633383) Khalid Al-Haithami (21633386) Ghanim Al-Mannai (21633389) Noha Barhom (14150748) Shailaja Tharupeedikayil (21633392) Faleh Tamimi (2867255) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nadya Marouf (14150724) Raidan Ba-Hattab (17773230) Fatima Al-Sheeb (21633377) Amal Diab (21633380) Hanan Diab (14779462) Maryam Al-Majed (21633383) Khalid Al-Haithami (21633386) Ghanim Al-Mannai (21633389) Noha Barhom (14150748) Shailaja Tharupeedikayil (21633392) Faleh Tamimi (2867255) |
| dc.date.none.fl_str_mv | 2024-07-04T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.identj.2024.01.002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/COVID-19_Severity_in_Patients_With_Apical_Periodontitis_A_Case_Control_Study/29445950 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Dentistry Health sciences Epidemiology Public health Biomarkers Inflammation Oral diseases Periapical diseases Radiography panoramic SARS-CoV-2 |
| dc.title.none.fl_str_mv | COVID-19 Severity in Patients With Apical Periodontitis: A Case Control Study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Objectives</h3><p dir="ltr">Apical <u>periodontitis </u>(AP) has been associated with systemic inflammatory biomarkers that have also been associated with COVID-19 severity. This study was designed to test the hypothesis that the presence of apical periodontitis could be associated with increased risk of COVID-19 complications. </p><h3>Methods</h3><p dir="ltr">A case control study (<i>N</i> = 949) was performed using the medical and dental records of patients diagnosed with COVID-19 in the State of Qatar between March 2020 and February 2021. Cases comprised COVID-19 patients (<i>n</i> = 63) who experienced complications (death, <u>intensive care unit </u>admissions, mechanical ventilation), and controls were COVID-19 patients (<i>n</i> = 886) who recovered without such complications. The presence of periapical apical periodontitis was assessed on the radiographic records taken prior to COVID-19 infection. Associations between apical periodontitis and <u>COVID 19 </u>complications were analysed using <u>logistic regression</u> models adjusted for demographic and medical factors. Blood biomarkers were assessed in both groups and compared using the Kruskal–Wallis test. </p><h3>Results</h3><p dir="ltr">COVID-19 complications were found to be associated with the presence of apical periodontitis (adjusted odds ratio = 2.72; 95% CI, 1.30–5.68; <i>P </i>= .008). Blood analyses revealed that COVID-19 patients with apical periodontitis had higher levels of white blood cells and <u>haemoglobin A1c </u>than the patients without apical periodontitis. </p><h3>Conclusions</h3><p dir="ltr">The presence of apical periodontitis could be associated with increased risk of COVID-19 complications.</p><h2>Other Information</h2><p dir="ltr">Published in: International Dental Journal<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.identj.2024.01.002" target="_blank">https://dx.doi.org/10.1016/j.identj.2024.01.002</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_bf73fc81e071f2e18261f075278c04df |
| identifier_str_mv | 10.1016/j.identj.2024.01.002 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29445950 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | COVID-19 Severity in Patients With Apical Periodontitis: A Case Control StudyNadya Marouf (14150724)Raidan Ba-Hattab (17773230)Fatima Al-Sheeb (21633377)Amal Diab (21633380)Hanan Diab (14779462)Maryam Al-Majed (21633383)Khalid Al-Haithami (21633386)Ghanim Al-Mannai (21633389)Noha Barhom (14150748)Shailaja Tharupeedikayil (21633392)Faleh Tamimi (2867255)Biomedical and clinical sciencesDentistryHealth sciencesEpidemiologyPublic healthBiomarkersInflammationOral diseasesPeriapical diseasesRadiography panoramicSARS-CoV-2<h3>Objectives</h3><p dir="ltr">Apical <u>periodontitis </u>(AP) has been associated with systemic inflammatory biomarkers that have also been associated with COVID-19 severity. This study was designed to test the hypothesis that the presence of apical periodontitis could be associated with increased risk of COVID-19 complications. </p><h3>Methods</h3><p dir="ltr">A case control study (<i>N</i> = 949) was performed using the medical and dental records of patients diagnosed with COVID-19 in the State of Qatar between March 2020 and February 2021. Cases comprised COVID-19 patients (<i>n</i> = 63) who experienced complications (death, <u>intensive care unit </u>admissions, mechanical ventilation), and controls were COVID-19 patients (<i>n</i> = 886) who recovered without such complications. The presence of periapical apical periodontitis was assessed on the radiographic records taken prior to COVID-19 infection. Associations between apical periodontitis and <u>COVID 19 </u>complications were analysed using <u>logistic regression</u> models adjusted for demographic and medical factors. Blood biomarkers were assessed in both groups and compared using the Kruskal–Wallis test. </p><h3>Results</h3><p dir="ltr">COVID-19 complications were found to be associated with the presence of apical periodontitis (adjusted odds ratio = 2.72; 95% CI, 1.30–5.68; <i>P </i>= .008). Blood analyses revealed that COVID-19 patients with apical periodontitis had higher levels of white blood cells and <u>haemoglobin A1c </u>than the patients without apical periodontitis. </p><h3>Conclusions</h3><p dir="ltr">The presence of apical periodontitis could be associated with increased risk of COVID-19 complications.</p><h2>Other Information</h2><p dir="ltr">Published in: International Dental Journal<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.identj.2024.01.002" target="_blank">https://dx.doi.org/10.1016/j.identj.2024.01.002</a></p>2024-07-04T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.identj.2024.01.002https://figshare.com/articles/journal_contribution/COVID-19_Severity_in_Patients_With_Apical_Periodontitis_A_Case_Control_Study/29445950CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/294459502024-07-04T06:00:00Z |
| spellingShingle | COVID-19 Severity in Patients With Apical Periodontitis: A Case Control Study Nadya Marouf (14150724) Biomedical and clinical sciences Dentistry Health sciences Epidemiology Public health Biomarkers Inflammation Oral diseases Periapical diseases Radiography panoramic SARS-CoV-2 |
| status_str | publishedVersion |
| title | COVID-19 Severity in Patients With Apical Periodontitis: A Case Control Study |
| title_full | COVID-19 Severity in Patients With Apical Periodontitis: A Case Control Study |
| title_fullStr | COVID-19 Severity in Patients With Apical Periodontitis: A Case Control Study |
| title_full_unstemmed | COVID-19 Severity in Patients With Apical Periodontitis: A Case Control Study |
| title_short | COVID-19 Severity in Patients With Apical Periodontitis: A Case Control Study |
| title_sort | COVID-19 Severity in Patients With Apical Periodontitis: A Case Control Study |
| topic | Biomedical and clinical sciences Dentistry Health sciences Epidemiology Public health Biomarkers Inflammation Oral diseases Periapical diseases Radiography panoramic SARS-CoV-2 |