Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons
<p>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by the loss of motor neurons. We utilized single-cell transcriptomics to uncover dysfunctional pathways in degenerating motor neurons differentiated from SOD1 E100G ALS patient-derived induced pluripote...
Saved in:
| Main Author: | Seema C. Namboori (11031624) (author) |
|---|---|
| Other Authors: | Patricia Thomas (3489989) (author), Ryan Ames (3486263) (author), Sophie Hawkins (18421377) (author), Lawrence O. Garrett (18589426) (author), Craig R.G. Willis (18589429) (author), Alessandro Rosa (470248) (author), Lawrence W. Stanton (6707191) (author), Akshay Bhinge (173004) (author) |
| Published: |
2021
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes
by: Maryam Aghadi (17128819)
Published: (2022) -
Deletion of TRPC6, an Autism Risk Gene, Induces Hyperexcitability in Cortical Neurons Derived from Human Pluripotent Stem Cells
by: Kyung Chul Shin (13913556)
Published: (2023) -
Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis
by: Sophie Hawkins (18421377)
Published: (2022) -
Assessing the consistency of iPSC and animal models in cystic fibrosis modelling: A meta-analysis
by: Toqa Darwish (13222230)
Published: (2022) -
iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes
by: Noura Aldous (15429873)
Published: (2023)