Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons

<p>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by the loss of motor neurons. We utilized single-cell transcriptomics to uncover dysfunctional pathways in degenerating motor neurons differentiated from SOD1 E100G ALS patient-derived induced pluripote...

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Bibliographic Details
Main Author:	Seema C. Namboori (11031624) (author)
Other Authors:	Patricia Thomas (3489989) (author), Ryan Ames (3486263) (author), Sophie Hawkins (18421377) (author), Lawrence O. Garrett (18589426) (author), Craig R.G. Willis (18589429) (author), Alessandro Rosa (470248) (author), Lawrence W. Stanton (6707191) (author), Akshay Bhinge (173004) (author)
Published:	2021
Subjects:	Biological sciences Genetics Biomedical and clinical sciences Neurosciences ALS iPSC SOD1 spinal MN single-cell RNA-seq networks TGFβ developmental pathways
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Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons

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