Comparing metabolic profiles between female endurance athletes and non-athletes reveals differences in androgen and corticosteroid levels
<p dir="ltr">Endurance training is associated with physiological changes in elite athletes, but little is known about female-specific effects of endurance training. Despite the significant rise in female sports participation, findings from studies performed on male athletes are large...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , |
| منشور في: |
2022
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513535804964864 |
|---|---|
| author | Amneh H. Tarkhan (8552667) |
| author2 | Najeha R. Anwardeen (15184882) Maha Sellami (4351159) Francesco Donati (4741020) Francesco Botrè (4741056) Xavier de la Torre (2813878) Mohamed A. Elrayess (7956179) |
| author2_role | author author author author author author |
| author_facet | Amneh H. Tarkhan (8552667) Najeha R. Anwardeen (15184882) Maha Sellami (4351159) Francesco Donati (4741020) Francesco Botrè (4741056) Xavier de la Torre (2813878) Mohamed A. Elrayess (7956179) |
| author_role | author |
| dc.creator.none.fl_str_mv | Amneh H. Tarkhan (8552667) Najeha R. Anwardeen (15184882) Maha Sellami (4351159) Francesco Donati (4741020) Francesco Botrè (4741056) Xavier de la Torre (2813878) Mohamed A. Elrayess (7956179) |
| dc.date.none.fl_str_mv | 2022-05-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.jsbmb.2022.106081 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Comparing_metabolic_profiles_between_female_endurance_athletes_and_non-athletes_reveals_differences_in_androgen_and_corticosteroid_levels/24745803 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Health sciences Sports science and exercise Psychology Biological psychology steroids endurance training metabolomics female athletes sports |
| dc.title.none.fl_str_mv | Comparing metabolic profiles between female endurance athletes and non-athletes reveals differences in androgen and corticosteroid levels |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Endurance training is associated with physiological changes in elite athletes, but little is known about female-specific effects of endurance training. Despite the significant rise in female sports participation, findings from studies performed on male athletes are largely extrapolated to females without taking into consideration sex-specific differences in metabolism. Subsequently, this study aimed to investigate the steroid hormone profiles of elite female endurance athletes in comparison with their non-athletic counterparts. Untargeted metabolomics-based mass spectroscopy combined with ultra-high-performance liquid chromatography was performed on serum samples from 51 elite female endurance athletes and 197 non-athletic females. The results showed that, compared to non-athletic females, certain androgen, pregnenolone, and progestin steroid hormones were reduced in elite female endurance athletes, while corticosteroids were elevated. The most significantly altered steroid hormones were 5alpha-androstan-3alpha,17alpha-diol monosulfate (FDR = 1.90 × 10-<sup>05</sup>), androstenediol (3alpha, 17alpha) monosulfate (FDR = 2.93 × 10-<sup>04</sup>), and cortisol (FDR = 2.93 × 10-<sup>04</sup>). Conclusively, the present study suggests that elite female endurance athletes have a unique steroid hormone profile with implications on their general health and performance.</p><h2>Other Information</h2><p dir="ltr">Published in: The Journal of Steroid Biochemistry and Molecular Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jsbmb.2022.106081" target="_blank">https://dx.doi.org/10.1016/j.jsbmb.2022.106081</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_c05ddb1f96f6b763ec82fc5a2dad9a3c |
| identifier_str_mv | 10.1016/j.jsbmb.2022.106081 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24745803 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Comparing metabolic profiles between female endurance athletes and non-athletes reveals differences in androgen and corticosteroid levelsAmneh H. Tarkhan (8552667)Najeha R. Anwardeen (15184882)Maha Sellami (4351159)Francesco Donati (4741020)Francesco Botrè (4741056)Xavier de la Torre (2813878)Mohamed A. Elrayess (7956179)Biomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicsHealth sciencesSports science and exercisePsychologyBiological psychologysteroidsendurance trainingmetabolomicsfemaleathletessports<p dir="ltr">Endurance training is associated with physiological changes in elite athletes, but little is known about female-specific effects of endurance training. Despite the significant rise in female sports participation, findings from studies performed on male athletes are largely extrapolated to females without taking into consideration sex-specific differences in metabolism. Subsequently, this study aimed to investigate the steroid hormone profiles of elite female endurance athletes in comparison with their non-athletic counterparts. Untargeted metabolomics-based mass spectroscopy combined with ultra-high-performance liquid chromatography was performed on serum samples from 51 elite female endurance athletes and 197 non-athletic females. The results showed that, compared to non-athletic females, certain androgen, pregnenolone, and progestin steroid hormones were reduced in elite female endurance athletes, while corticosteroids were elevated. The most significantly altered steroid hormones were 5alpha-androstan-3alpha,17alpha-diol monosulfate (FDR = 1.90 × 10-<sup>05</sup>), androstenediol (3alpha, 17alpha) monosulfate (FDR = 2.93 × 10-<sup>04</sup>), and cortisol (FDR = 2.93 × 10-<sup>04</sup>). Conclusively, the present study suggests that elite female endurance athletes have a unique steroid hormone profile with implications on their general health and performance.</p><h2>Other Information</h2><p dir="ltr">Published in: The Journal of Steroid Biochemistry and Molecular Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jsbmb.2022.106081" target="_blank">https://dx.doi.org/10.1016/j.jsbmb.2022.106081</a></p>2022-05-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.jsbmb.2022.106081https://figshare.com/articles/journal_contribution/Comparing_metabolic_profiles_between_female_endurance_athletes_and_non-athletes_reveals_differences_in_androgen_and_corticosteroid_levels/24745803CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/247458032022-05-01T00:00:00Z |
| spellingShingle | Comparing metabolic profiles between female endurance athletes and non-athletes reveals differences in androgen and corticosteroid levels Amneh H. Tarkhan (8552667) Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Health sciences Sports science and exercise Psychology Biological psychology steroids endurance training metabolomics female athletes sports |
| status_str | publishedVersion |
| title | Comparing metabolic profiles between female endurance athletes and non-athletes reveals differences in androgen and corticosteroid levels |
| title_full | Comparing metabolic profiles between female endurance athletes and non-athletes reveals differences in androgen and corticosteroid levels |
| title_fullStr | Comparing metabolic profiles between female endurance athletes and non-athletes reveals differences in androgen and corticosteroid levels |
| title_full_unstemmed | Comparing metabolic profiles between female endurance athletes and non-athletes reveals differences in androgen and corticosteroid levels |
| title_short | Comparing metabolic profiles between female endurance athletes and non-athletes reveals differences in androgen and corticosteroid levels |
| title_sort | Comparing metabolic profiles between female endurance athletes and non-athletes reveals differences in androgen and corticosteroid levels |
| topic | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Health sciences Sports science and exercise Psychology Biological psychology steroids endurance training metabolomics female athletes sports |