Microbiome‐modulating nutraceuticals ameliorate dyslipidemia in type 2 diabetes: A systematic review, meta‐analysis, and meta‐regression of clinical trials
<h3>Aims</h3><p dir="ltr">Type 2 Diabetes is intrinsically linked to cardiovascular disease (CVD) via diabetic dyslipidemia, both of which remain global health concerns with annually increasing prevalence. Given the established links between gut microbiome dysbiosis and m...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| منشور في: |
2023
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513555989004288 |
|---|---|
| author | Ridhima Kaul (12485902) |
| author2 | Pradipta Paul (12628162) Manale Harfouche (4557211) Reya Saliba (12628168) Ali Chaari (827168) |
| author2_role | author author author author |
| author_facet | Ridhima Kaul (12485902) Pradipta Paul (12628162) Manale Harfouche (4557211) Reya Saliba (12628168) Ali Chaari (827168) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ridhima Kaul (12485902) Pradipta Paul (12628162) Manale Harfouche (4557211) Reya Saliba (12628168) Ali Chaari (827168) |
| dc.date.none.fl_str_mv | 2023-06-28T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/dmrr.3675 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Microbiome_modulating_nutraceuticals_ameliorate_dyslipidemia_in_type_2_diabetes_A_systematic_review_meta_analysis_and_meta_regression_of_clinical_trials/27130068 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Nutrition and dietetics gut flora gut microbiome hypercholesterolaemia prebiotic probiotic synbiotic |
| dc.title.none.fl_str_mv | Microbiome‐modulating nutraceuticals ameliorate dyslipidemia in type 2 diabetes: A systematic review, meta‐analysis, and meta‐regression of clinical trials |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Aims</h3><p dir="ltr">Type 2 Diabetes is intrinsically linked to cardiovascular disease (CVD) via diabetic dyslipidemia, both of which remain global health concerns with annually increasing prevalence. Given the established links between gut microbiome dysbiosis and metabolic diseases, its modulation is an attractive target to ameliorate metabolic imbalances in such patients. There is a need to quantitively summarise, analyse, and describe future directions in this field.</p><h3>Methods</h3><p dir="ltr">We conducted a systematic review, meta‐analysis, and meta‐regression following searches in major scientific databases for clinical trials investigating the effect of pro/pre/synbiotics on lipid profile published until April 2022. Data were pooled using random‐effects meta‐analysis and reported as mean differences with 95% confidence intervals (CIs). PROSPERO No. CRD42022348525.</p><h3>Results</h3><p dir="ltr">Data from 47 trial comparisons across 42 studies (n = 2692) revealed that, compared to placebo/control groups, the administration of pro/pre/synbiotics was associated with statistically significant changes in total cholesterol (−9.97 mg/dL [95% CI: −15.08; −4.87], p < 0.0001), low‐density lipoprotein (−6.29 mg/dL [95% CI: −9.25; −3.33], p < 0.0001), high‐density lipoprotein (+3.21 mg/dL [95% CI: 2.20; 4.22], p < 0.0001), very‐low‐density lipoprotein (−4.52 mg/dL [95% CI: −6.36; −2.67], p < 0.0001) and triglyceride (−22.93 mg/dL [95% CI: −33.99; −11.87], p < 0.001). These results are influenced by patient characteristics such as age or baseline BMI, and intervention characteristics such as dosage and duration.</p><h3>Conclusions</h3><p dir="ltr">Our study shows that adjunct supplementation with a subset of pro/pre/synbiotics ameliorates dyslipidemia in diabetic individuals and has the potential to reduce CVD risk. However, widespread inter‐study heterogeneity and the presence of several unknown confounders limit their adoption in clinical practice; future trials should be designed with these in mind.</p><h2>Other Information</h2><p dir="ltr">Published in: Diabetes/Metabolism Research and Reviews<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/dmrr.3675" target="_blank">https://dx.doi.org/10.1002/dmrr.3675</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_c1c83b07b6011419acc67fe36a8f634a |
| identifier_str_mv | 10.1002/dmrr.3675 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27130068 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Microbiome‐modulating nutraceuticals ameliorate dyslipidemia in type 2 diabetes: A systematic review, meta‐analysis, and meta‐regression of clinical trialsRidhima Kaul (12485902)Pradipta Paul (12628162)Manale Harfouche (4557211)Reya Saliba (12628168)Ali Chaari (827168)Biomedical and clinical sciencesCardiovascular medicine and haematologyNutrition and dieteticsgut floragut microbiomehypercholesterolaemiaprebioticprobioticsynbiotic<h3>Aims</h3><p dir="ltr">Type 2 Diabetes is intrinsically linked to cardiovascular disease (CVD) via diabetic dyslipidemia, both of which remain global health concerns with annually increasing prevalence. Given the established links between gut microbiome dysbiosis and metabolic diseases, its modulation is an attractive target to ameliorate metabolic imbalances in such patients. There is a need to quantitively summarise, analyse, and describe future directions in this field.</p><h3>Methods</h3><p dir="ltr">We conducted a systematic review, meta‐analysis, and meta‐regression following searches in major scientific databases for clinical trials investigating the effect of pro/pre/synbiotics on lipid profile published until April 2022. Data were pooled using random‐effects meta‐analysis and reported as mean differences with 95% confidence intervals (CIs). PROSPERO No. CRD42022348525.</p><h3>Results</h3><p dir="ltr">Data from 47 trial comparisons across 42 studies (n = 2692) revealed that, compared to placebo/control groups, the administration of pro/pre/synbiotics was associated with statistically significant changes in total cholesterol (−9.97 mg/dL [95% CI: −15.08; −4.87], p < 0.0001), low‐density lipoprotein (−6.29 mg/dL [95% CI: −9.25; −3.33], p < 0.0001), high‐density lipoprotein (+3.21 mg/dL [95% CI: 2.20; 4.22], p < 0.0001), very‐low‐density lipoprotein (−4.52 mg/dL [95% CI: −6.36; −2.67], p < 0.0001) and triglyceride (−22.93 mg/dL [95% CI: −33.99; −11.87], p < 0.001). These results are influenced by patient characteristics such as age or baseline BMI, and intervention characteristics such as dosage and duration.</p><h3>Conclusions</h3><p dir="ltr">Our study shows that adjunct supplementation with a subset of pro/pre/synbiotics ameliorates dyslipidemia in diabetic individuals and has the potential to reduce CVD risk. However, widespread inter‐study heterogeneity and the presence of several unknown confounders limit their adoption in clinical practice; future trials should be designed with these in mind.</p><h2>Other Information</h2><p dir="ltr">Published in: Diabetes/Metabolism Research and Reviews<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/dmrr.3675" target="_blank">https://dx.doi.org/10.1002/dmrr.3675</a></p>2023-06-28T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/dmrr.3675https://figshare.com/articles/journal_contribution/Microbiome_modulating_nutraceuticals_ameliorate_dyslipidemia_in_type_2_diabetes_A_systematic_review_meta_analysis_and_meta_regression_of_clinical_trials/27130068CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/271300682023-06-28T03:00:00Z |
| spellingShingle | Microbiome‐modulating nutraceuticals ameliorate dyslipidemia in type 2 diabetes: A systematic review, meta‐analysis, and meta‐regression of clinical trials Ridhima Kaul (12485902) Biomedical and clinical sciences Cardiovascular medicine and haematology Nutrition and dietetics gut flora gut microbiome hypercholesterolaemia prebiotic probiotic synbiotic |
| status_str | publishedVersion |
| title | Microbiome‐modulating nutraceuticals ameliorate dyslipidemia in type 2 diabetes: A systematic review, meta‐analysis, and meta‐regression of clinical trials |
| title_full | Microbiome‐modulating nutraceuticals ameliorate dyslipidemia in type 2 diabetes: A systematic review, meta‐analysis, and meta‐regression of clinical trials |
| title_fullStr | Microbiome‐modulating nutraceuticals ameliorate dyslipidemia in type 2 diabetes: A systematic review, meta‐analysis, and meta‐regression of clinical trials |
| title_full_unstemmed | Microbiome‐modulating nutraceuticals ameliorate dyslipidemia in type 2 diabetes: A systematic review, meta‐analysis, and meta‐regression of clinical trials |
| title_short | Microbiome‐modulating nutraceuticals ameliorate dyslipidemia in type 2 diabetes: A systematic review, meta‐analysis, and meta‐regression of clinical trials |
| title_sort | Microbiome‐modulating nutraceuticals ameliorate dyslipidemia in type 2 diabetes: A systematic review, meta‐analysis, and meta‐regression of clinical trials |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Nutrition and dietetics gut flora gut microbiome hypercholesterolaemia prebiotic probiotic synbiotic |